A high-performance liquid chromatography-thermospray mass spectrometry method has been developed for the determination of taxol, found in the Taxus species. The compound is chromatographed by isocratic elution in 14 min and is quantitated by selected-ion recording of the protonated molecule. The method is linear over the range 1–1000 ng (1.2 pmol-1.2 nmol) of taxol per injection. The standard deviation of replicate bark samples (n = 6) was 12.8%.
Auriola, S., Lepistö, A-M., Naaranlahti, T., & Lapinjoki, S. (1992). Determination of taxol by high-performance liquid chromatography-thermospray mass spectrometry. Journal of Chromatography, 594(1-2), 153-158. https://doi.org/10.1016/0021-9673(92)80324-N