Determination of taxol by high-performance liquid chromatography-thermospray mass spectrometry

Seppo Auriola, Anna-Maija Lepistö, Toivo Naaranlahti, Seppo Lapinjoki

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Abstract

A high-performance liquid chromatography-thermospray mass spectrometry method has been developed for the determination of taxol, found in the Taxus species. The compound is chromatographed by isocratic elution in 14 min and is quantitated by selected-ion recording of the protonated molecule. The method is linear over the range 1–1000 ng (1.2 pmol-1.2 nmol) of taxol per injection. The standard deviation of replicate bark samples (n = 6) was 12.8%.
Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalJournal of Chromatography
Volume594
Issue number1-2
DOIs
Publication statusPublished - 1992
MoE publication typeA1 Journal article-refereed

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