Abstract
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the 3rd European Medical and Biological Engineering Conference, IFMBE Proceedings, 2005 |
| Publication status | Published - 2005 |
| MoE publication type | A4 Article in a conference publication |
| Event | 3rd European Medical and Biological Engineering Conference, EMBEC'05 - Prague, Czech Republic Duration: 20 Nov 2005 → 25 Nov 2005 |
Publication series
| Series | IFMBE Proceedings |
|---|---|
| Volume | 11 |
| ISSN | 1680-0737 |
Conference
| Conference | 3rd European Medical and Biological Engineering Conference, EMBEC'05 |
|---|---|
| Abbreviated title | EMBEC |
| Country | Czech Republic |
| City | Prague |
| Period | 20/11/05 → 25/11/05 |
Fingerprint
Keywords
- analgesia
- depth of anaesthesia
- heart-rate variability
Cite this
}
Development of an index for assessment of nociception at incision during surgery. / van Gils, Mark; Korhonen, Ilkka; Huiku, M.; Yppärilä-Wolters, Heidi; Viertiö-Oja, H.; Meriläinen, P.; Kymäläinen, M.; Takala, P.; Uutela, K.; Rantanen, M.; Yli-Hankala, A.
Proceedings of the 3rd European Medical and Biological Engineering Conference, IFMBE Proceedings, 2005. 2005. 1529F (IFMBE Proceedings, Vol. 11).Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review
TY - GEN
T1 - Development of an index for assessment of nociception at incision during surgery
AU - van Gils, Mark
AU - Korhonen, Ilkka
AU - Huiku, M.
AU - Yppärilä-Wolters, Heidi
AU - Viertiö-Oja, H.
AU - Meriläinen, P.
AU - Kymäläinen, M.
AU - Takala, P.
AU - Uutela, K.
AU - Rantanen, M.
AU - Yli-Hankala, A.
PY - 2005
Y1 - 2005
N2 - Abstract: Currently no objective direct indicator for nociception in anaesthetised patients exists. We aimed to find an indicator by combining physiological parameters obtained at the moment of skin incision during surgery. 55 females were anaesthetised with propofol-remifentanil target controlled infusions. Propofol was given to maintain a State Entropy of 50. Remifentanil target was randomised to 1, 3, or 5 ng/ml. Electrocardiogram, photoplethysmography (PPG), and EEG spectral entropy were recorded and analysed off-line, starting 60 s before and lasting until 120 s after skin incision. Patient reactions were annotated. Heart rate variability (HRV), PPG signal, and pulse transition time (PTT) related features were derived. Clinical signs, remifentanil levels and estimated intensity of incision were combined into a clinical score (CSSA) associated with probability of nociception. Physiological features were analysed to find a predictor (RN) of CSSA. This was achieved by combining features from HRV, spectral entropy, and PPG. The prediction-probabilty (Pk) of CSSA estimation was 0.74. RN was higher after larger incision (P=0.04), in movers (P=0.02), and in patients with lower remifentanil concentrations (P=0.00001). Concluding, RN seems to adequately monitor the components of analgesia: intensity of noxious stimulus and drug effect, and be related to clinical signs of inadequate analgesia
AB - Abstract: Currently no objective direct indicator for nociception in anaesthetised patients exists. We aimed to find an indicator by combining physiological parameters obtained at the moment of skin incision during surgery. 55 females were anaesthetised with propofol-remifentanil target controlled infusions. Propofol was given to maintain a State Entropy of 50. Remifentanil target was randomised to 1, 3, or 5 ng/ml. Electrocardiogram, photoplethysmography (PPG), and EEG spectral entropy were recorded and analysed off-line, starting 60 s before and lasting until 120 s after skin incision. Patient reactions were annotated. Heart rate variability (HRV), PPG signal, and pulse transition time (PTT) related features were derived. Clinical signs, remifentanil levels and estimated intensity of incision were combined into a clinical score (CSSA) associated with probability of nociception. Physiological features were analysed to find a predictor (RN) of CSSA. This was achieved by combining features from HRV, spectral entropy, and PPG. The prediction-probabilty (Pk) of CSSA estimation was 0.74. RN was higher after larger incision (P=0.04), in movers (P=0.02), and in patients with lower remifentanil concentrations (P=0.00001). Concluding, RN seems to adequately monitor the components of analgesia: intensity of noxious stimulus and drug effect, and be related to clinical signs of inadequate analgesia
KW - analgesia
KW - depth of anaesthesia
KW - heart-rate variability
M3 - Conference article in proceedings
T3 - IFMBE Proceedings
BT - Proceedings of the 3rd European Medical and Biological Engineering Conference, IFMBE Proceedings, 2005
ER -