Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes

S.-S. Kiwanuka, T.K. Laurila, J.H. Frank, A. Esposito, K. Blomberg von der Geest, L. Pancheri, D. Stoppa, C.F. Kaminski (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Abstract

We present a spectrometer for sensitive absorption measurements in liquids across broad spectral bandwidths. The spectrometer combines the unique spectral properties of incoherent supercontinuum light sources with the advantages of cavity ring-down spectroscopy, which is a self-calibrating technique. A custom-built avalanche photodiode array is used for detection, permitting the simultaneous measurement of ring-down times for up to 64 different spectral components at nanosecond temporal resolution. The minimum detectable absorption coefficient was measured to be 3.2 × 10–6 cm–1 Hz–1/2 at 527 nm. We show that the spectrometer is capable of recording spectral differences in trace levels of blood before and after hemolysis.
Original languageEnglish
Pages (from-to)5489-5493
JournalAnalytical Chemistry
Volume84
Issue number13
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fingerprint

Spectrometers
Spectroscopy
Liquids
Avalanche photodiodes
Light sources
Blood
Bandwidth

Keywords

  • spectroscopy
  • biomedical diagnostics

Cite this

Kiwanuka, S-S., Laurila, T. K., Frank, J. H., Esposito, A., Blomberg von der Geest, K., Pancheri, L., ... Kaminski, C. F. (2012). Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes. Analytical Chemistry, 84(13), 5489-5493. https://doi.org/10.1021/ac301108q
Kiwanuka, S.-S. ; Laurila, T.K. ; Frank, J.H. ; Esposito, A. ; Blomberg von der Geest, K. ; Pancheri, L. ; Stoppa, D. ; Kaminski, C.F. / Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes. In: Analytical Chemistry. 2012 ; Vol. 84, No. 13. pp. 5489-5493.
@article{28cc004432db43c8aa6685632721c2b2,
title = "Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes",
abstract = "We present a spectrometer for sensitive absorption measurements in liquids across broad spectral bandwidths. The spectrometer combines the unique spectral properties of incoherent supercontinuum light sources with the advantages of cavity ring-down spectroscopy, which is a self-calibrating technique. A custom-built avalanche photodiode array is used for detection, permitting the simultaneous measurement of ring-down times for up to 64 different spectral components at nanosecond temporal resolution. The minimum detectable absorption coefficient was measured to be 3.2 × 10–6 cm–1 Hz–1/2 at 527 nm. We show that the spectrometer is capable of recording spectral differences in trace levels of blood before and after hemolysis.",
keywords = "spectroscopy, biomedical diagnostics",
author = "S.-S. Kiwanuka and T.K. Laurila and J.H. Frank and A. Esposito and {Blomberg von der Geest}, K. and L. Pancheri and D. Stoppa and C.F. Kaminski",
year = "2012",
doi = "10.1021/ac301108q",
language = "English",
volume = "84",
pages = "5489--5493",
journal = "Analytical Chemistry",
issn = "0003-2700",
publisher = "American Chemical Society",
number = "13",

}

Kiwanuka, S-S, Laurila, TK, Frank, JH, Esposito, A, Blomberg von der Geest, K, Pancheri, L, Stoppa, D & Kaminski, CF 2012, 'Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes', Analytical Chemistry, vol. 84, no. 13, pp. 5489-5493. https://doi.org/10.1021/ac301108q

Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes. / Kiwanuka, S.-S.; Laurila, T.K.; Frank, J.H.; Esposito, A.; Blomberg von der Geest, K.; Pancheri, L.; Stoppa, D.; Kaminski, C.F. (Corresponding Author).

In: Analytical Chemistry, Vol. 84, No. 13, 2012, p. 5489-5493.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes

AU - Kiwanuka, S.-S.

AU - Laurila, T.K.

AU - Frank, J.H.

AU - Esposito, A.

AU - Blomberg von der Geest, K.

AU - Pancheri, L.

AU - Stoppa, D.

AU - Kaminski, C.F.

PY - 2012

Y1 - 2012

N2 - We present a spectrometer for sensitive absorption measurements in liquids across broad spectral bandwidths. The spectrometer combines the unique spectral properties of incoherent supercontinuum light sources with the advantages of cavity ring-down spectroscopy, which is a self-calibrating technique. A custom-built avalanche photodiode array is used for detection, permitting the simultaneous measurement of ring-down times for up to 64 different spectral components at nanosecond temporal resolution. The minimum detectable absorption coefficient was measured to be 3.2 × 10–6 cm–1 Hz–1/2 at 527 nm. We show that the spectrometer is capable of recording spectral differences in trace levels of blood before and after hemolysis.

AB - We present a spectrometer for sensitive absorption measurements in liquids across broad spectral bandwidths. The spectrometer combines the unique spectral properties of incoherent supercontinuum light sources with the advantages of cavity ring-down spectroscopy, which is a self-calibrating technique. A custom-built avalanche photodiode array is used for detection, permitting the simultaneous measurement of ring-down times for up to 64 different spectral components at nanosecond temporal resolution. The minimum detectable absorption coefficient was measured to be 3.2 × 10–6 cm–1 Hz–1/2 at 527 nm. We show that the spectrometer is capable of recording spectral differences in trace levels of blood before and after hemolysis.

KW - spectroscopy

KW - biomedical diagnostics

U2 - 10.1021/ac301108q

DO - 10.1021/ac301108q

M3 - Article

VL - 84

SP - 5489

EP - 5493

JO - Analytical Chemistry

JF - Analytical Chemistry

SN - 0003-2700

IS - 13

ER -

Kiwanuka S-S, Laurila TK, Frank JH, Esposito A, Blomberg von der Geest K, Pancheri L et al. Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes. Analytical Chemistry. 2012;84(13):5489-5493. https://doi.org/10.1021/ac301108q