Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes

S.-S. Kiwanuka, T.K. Laurila, J.H. Frank, A. Esposito, K. Blomberg von der Geest, L. Pancheri, D. Stoppa, C.F. Kaminski (Corresponding Author)

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Abstract

We present a spectrometer for sensitive absorption measurements in liquids across broad spectral bandwidths. The spectrometer combines the unique spectral properties of incoherent supercontinuum light sources with the advantages of cavity ring-down spectroscopy, which is a self-calibrating technique. A custom-built avalanche photodiode array is used for detection, permitting the simultaneous measurement of ring-down times for up to 64 different spectral components at nanosecond temporal resolution. The minimum detectable absorption coefficient was measured to be 3.2 × 10–6 cm–1 Hz–1/2 at 527 nm. We show that the spectrometer is capable of recording spectral differences in trace levels of blood before and after hemolysis.
Original languageEnglish
Pages (from-to)5489-5493
JournalAnalytical Chemistry
Volume84
Issue number13
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

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Keywords

  • spectroscopy
  • biomedical diagnostics

Cite this

Kiwanuka, S-S., Laurila, T. K., Frank, J. H., Esposito, A., Blomberg von der Geest, K., Pancheri, L., Stoppa, D., & Kaminski, C. F. (2012). Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes. Analytical Chemistry, 84(13), 5489-5493. https://doi.org/10.1021/ac301108q