Development of self-assembled MIPs

Inger Vikholm, Kirsi Tappura, Martin Albers

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

Abstract

Lipoate derivatives were used for the formation of self-assembled imprinted thin molecular films (SA-MIPs) for the recognition of morphine. A large collection of lipoate derivatives was screened by molecular dynamics studies in various solvents. The most interesting candidates of building blocks were synthesized, and monolayer formation was studied in the absence and presence of morphine added as the template. The binding of ligands and morphine to gold, as well as the association/dissociation of morphine to the formed layers were studied with Surface Plasmon Resonance. The procedure of producing these thin films is experimentally straightforward, comprising only an adsorption (self-assembly) step, and a washing routine to remove bound template, without the need for polymerisation of the layer. The method, however, critically depends on which type of ligands is used. Imprinted factors were highly variable and were dependent on mixing ratio and pH.
Original languageEnglish
Title of host publication2nd World Congress on Synthetic Receptors. Programme and Abstracts. Salzburg, 7 - 9 Sept. 2005
Place of PublicationOxford, UK
PublisherElsevier
Publication statusPublished - 2005
MoE publication typeNot Eligible

Fingerprint

Morphine
Ligands
Derivatives
Surface plasmon resonance
Washing
Gold
Self assembly
Molecular dynamics
Monolayers
Polymerization
Association reactions
Adsorption
Thin films

Keywords

  • self-assembly
  • molecular printing
  • morphine
  • synthetic receptor

Cite this

Vikholm, I., Tappura, K., & Albers, M. (2005). Development of self-assembled MIPs. In 2nd World Congress on Synthetic Receptors. Programme and Abstracts. Salzburg, 7 - 9 Sept. 2005 [037] Oxford, UK: Elsevier.
Vikholm, Inger ; Tappura, Kirsi ; Albers, Martin. / Development of self-assembled MIPs. 2nd World Congress on Synthetic Receptors. Programme and Abstracts. Salzburg, 7 - 9 Sept. 2005. Oxford, UK : Elsevier, 2005.
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Vikholm, I, Tappura, K & Albers, M 2005, Development of self-assembled MIPs. in 2nd World Congress on Synthetic Receptors. Programme and Abstracts. Salzburg, 7 - 9 Sept. 2005., 037, Elsevier, Oxford, UK.

Development of self-assembled MIPs. / Vikholm, Inger; Tappura, Kirsi; Albers, Martin.

2nd World Congress on Synthetic Receptors. Programme and Abstracts. Salzburg, 7 - 9 Sept. 2005. Oxford, UK : Elsevier, 2005. 037.

Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

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AB - Lipoate derivatives were used for the formation of self-assembled imprinted thin molecular films (SA-MIPs) for the recognition of morphine. A large collection of lipoate derivatives was screened by molecular dynamics studies in various solvents. The most interesting candidates of building blocks were synthesized, and monolayer formation was studied in the absence and presence of morphine added as the template. The binding of ligands and morphine to gold, as well as the association/dissociation of morphine to the formed layers were studied with Surface Plasmon Resonance. The procedure of producing these thin films is experimentally straightforward, comprising only an adsorption (self-assembly) step, and a washing routine to remove bound template, without the need for polymerisation of the layer. The method, however, critically depends on which type of ligands is used. Imprinted factors were highly variable and were dependent on mixing ratio and pH.

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Vikholm I, Tappura K, Albers M. Development of self-assembled MIPs. In 2nd World Congress on Synthetic Receptors. Programme and Abstracts. Salzburg, 7 - 9 Sept. 2005. Oxford, UK: Elsevier. 2005. 037