Abstract
The reaction of {\beta}- and {\gamma}-haloamines with
carbon dioxide to give pharmaceutically relevant
2-oxazolidinones and 1,3-dioxazin-2-ones, was found to
proceed efficiently in the presence of a base and in the
absence of catalyst. After optimization of reaction
conditions, the system was successfully expanded to a
variety of haloamines, even at multigram scale. The
reaction was further studied in silico by DFT
calculations.
| Original language | English |
|---|---|
| Pages (from-to) | 8867-8871 |
| Journal | Chemistry - A European Journal |
| Volume | 20 |
| Issue number | 29 |
| DOIs | |
| Publication status | Published - 2014 |
| MoE publication type | A1 Journal article-refereed |
Keywords
- 2-oxazolidones
- antibiotics
- carbon dioxide activation
- carbon dioxide fixation
- density functional calculations
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Niemi, T., Perea-Buceta, J. E., Fernandez, I., Alakurtti, S., Rantala, E., & Repo, T. (2014). Direct assembly of 2-oxazolidinones by chemical fixation of carbon dioxide. Chemistry - A European Journal, 20(29), 8867-8871. https://doi.org/10.1002/chem.201402368