Abstract
The reaction of β- and γ-haloamines with carbon dioxide to give pharmaceutically relevant 2-oxazolidinones and 1,3-dioxazin-2-ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations.
Original language | English |
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Pages (from-to) | 8867-8871 |
Journal | Chemistry - A European Journal |
Volume | 20 |
Issue number | 29 |
DOIs | |
Publication status | Published - 2014 |
MoE publication type | A1 Journal article-refereed |
Keywords
- 2-oxazolidones
- antibiotics
- carbon dioxide activation
- carbon dioxide fixation
- density functional calculations