Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 8867-8871 |
| Journal | Chemistry - A European Journal |
| Volume | 20 |
| Issue number | 29 |
| DOIs | |
| Publication status | Published - 2014 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- 2-oxazolidones
- antibiotics
- carbon dioxide activation
- carbon dioxide fixation
- density functional calculations
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Direct assembly of 2-oxazolidinones by chemical fixation of carbon dioxide. / Niemi, T; Perea-Buceta, J E; Fernandez, I; Alakurtti, Sami; Rantala, Elina; Repo, T (Corresponding Author).
In: Chemistry - A European Journal, Vol. 20, No. 29, 2014, p. 8867-8871.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Direct assembly of 2-oxazolidinones by chemical fixation of carbon dioxide
AU - Niemi, T
AU - Perea-Buceta, J E
AU - Fernandez, I
AU - Alakurtti, Sami
AU - Rantala, Elina
AU - Repo, T
PY - 2014
Y1 - 2014
N2 - The reaction of {\beta}- and {\gamma}-haloamines with carbon dioxide to give pharmaceutically relevant 2-oxazolidinones and 1,3-dioxazin-2-ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations.
AB - The reaction of {\beta}- and {\gamma}-haloamines with carbon dioxide to give pharmaceutically relevant 2-oxazolidinones and 1,3-dioxazin-2-ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations.
KW - 2-oxazolidones
KW - antibiotics
KW - carbon dioxide activation
KW - carbon dioxide fixation
KW - density functional calculations
U2 - 10.1002/chem.201402368
DO - 10.1002/chem.201402368
M3 - Article
VL - 20
SP - 8867
EP - 8871
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
SN - 0947-6539
IS - 29
ER -