Direct insertion membrane probe for selective introduction of organic compounds into a mass spectrometer

M. Bier, R. Cooks, Tapio Kotiaho

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

A direct insertion membrane probe for the direct determination of organic compounds in aqueous samples has been designed and built. This device allows the transportation of analyte solution over a sheet membrane via which pervaporation transports compounds directly into the heated ion source of a mass spectrometer. This configuration, together with the possibility of temperature control at the solution/membrane interface, decreases response times (typically <10 s) and memory effects and gives very good sensitivity and low detection limits (down to 10 μg l−1). Optimization of different parameters which affect the performance of the device is reported. High probe temperatures and high flow-rates are generally preferred, giving increased sensitivity. A knowledge of the sample matrix is essential in precise quantitative analysis, because matrix components can change permeation rates and ionization efficiencies. The usefulness of the device in bioreactor monitoring and in environmental analysis is demonstrated.
Original languageEnglish
Pages (from-to)175-190
JournalAnalytica Chimica Acta
Volume231
DOIs
Publication statusPublished - 1990
MoE publication typeA1 Journal article-refereed

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Mass spectrometers
Organic compounds
organic compound
spectrometer
probe
membrane
Membranes
Equipment and Supplies
Pervaporation
Temperature
matrix
Environmental Monitoring
Bioreactors
Ion sources
Temperature control
Permeation
bioreactor
quantitative analysis
Reaction Time
Ionization

Cite this

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abstract = "A direct insertion membrane probe for the direct determination of organic compounds in aqueous samples has been designed and built. This device allows the transportation of analyte solution over a sheet membrane via which pervaporation transports compounds directly into the heated ion source of a mass spectrometer. This configuration, together with the possibility of temperature control at the solution/membrane interface, decreases response times (typically <10 s) and memory effects and gives very good sensitivity and low detection limits (down to 10 μg l−1). Optimization of different parameters which affect the performance of the device is reported. High probe temperatures and high flow-rates are generally preferred, giving increased sensitivity. A knowledge of the sample matrix is essential in precise quantitative analysis, because matrix components can change permeation rates and ionization efficiencies. The usefulness of the device in bioreactor monitoring and in environmental analysis is demonstrated.",
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Direct insertion membrane probe for selective introduction of organic compounds into a mass spectrometer. / Bier, M.; Cooks, R.; Kotiaho, Tapio.

In: Analytica Chimica Acta, Vol. 231, 1990, p. 175-190.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Direct insertion membrane probe for selective introduction of organic compounds into a mass spectrometer

AU - Bier, M.

AU - Cooks, R.

AU - Kotiaho, Tapio

PY - 1990

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U2 - 10.1016/S0003-2670(00)86416-8

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VL - 231

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JO - Analytica Chimica Acta

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