Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Elli Käpylä; Tomáš Sedlačík; Dogu Baran Aydogan; Jouko Viitanen; František Rypáček; Minna Kellomäki

doi:10.1016/j.msec.2014.07.027

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Elli Käpylä (Corresponding Author), Tomáš Sedlačík, Dogu Baran Aydogan, Jouko Viitanen, František Rypáček, Minna Kellomäki

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

39 Citations (Scopus)

Abstract

The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

Original language	English
Pages (from-to)	280-289
Journal	Materials Science and Engineering C: Materials for Biological Applications
Volume	43
DOIs	https://doi.org/10.1016/j.msec.2014.07.027
Publication status	Published - 2014
MoE publication type	A1 Journal article-refereed

Keywords

direct laser writing
two-photon polymerization
microfabrication
hydrogels
polyamino acids
poly(ethylene glycol) diacrylate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.msec.2014.07.027

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title = "Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization",

abstract = "The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.",

keywords = "direct laser writing, two-photon polymerization, microfabrication, hydrogels, polyamino acids, poly(ethylene glycol) diacrylate",

author = "Elli K{\"a}pyl{\"a} and Tom{\'a}{\v s} Sedla{\v c}{\'i}k and Aydogan, {Dogu Baran} and Jouko Viitanen and Franti{\v s}ek Ryp{\'a}{\v c}ek and Minna Kellom{\"a}ki",

year = "2014",

doi = "10.1016/j.msec.2014.07.027",

language = "English",

volume = "43",

pages = "280--289",

journal = "Materials Science and Engineering C: Materials for Biological Applications",

issn = "0928-4931",

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}

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization. / Käpylä, Elli (Corresponding Author); Sedlačík, Tomáš; Aydogan, Dogu Baran et al.
In: Materials Science and Engineering C: Materials for Biological Applications, Vol. 43, 2014, p. 280-289.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

AU - Käpylä, Elli

AU - Sedlačík, Tomáš

AU - Aydogan, Dogu Baran

AU - Viitanen, Jouko

AU - Rypáček, František

AU - Kellomäki, Minna

PY - 2014

Y1 - 2014

N2 - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

AB - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

KW - direct laser writing

KW - two-photon polymerization

KW - microfabrication

KW - hydrogels

KW - polyamino acids

KW - poly(ethylene glycol) diacrylate

U2 - 10.1016/j.msec.2014.07.027

DO - 10.1016/j.msec.2014.07.027

M3 - Article

SN - 0928-4931

VL - 43

SP - 280

EP - 289

JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

ER -

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Abstract

Keywords

UN SDGs

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