Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

E. Käpylä (Corresponding Author), T. Sedlacík, D.B. Aydogan, Jouko Viitanen, F. Rypácek, M. Kellomäki

Research output: Contribution to journalArticleScientificpeer-review

16 Citations (Scopus)

Abstract

The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.
Original languageEnglish
Pages (from-to)280-289
JournalMaterials Science and Engineering C: Materials for Biological Applications
Volume43
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Fingerprint

Hydrogels
Polyethylene glycols
amino acids
Amino acids
glycols
ethylene
Photons
polymerization
Polymerization
Amino Acids
Lasers
photons
3D printers
lasers
Hydrogel
Microfabrication
biomimetics
Biomimetics
yield point
swelling

Keywords

  • direct laser writing
  • two-photon polymerization
  • microfabrication
  • hydrogels
  • polyamino acids
  • poly(ethylene glycol) diacrylate

Cite this

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title = "Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization",
abstract = "The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.",
keywords = "direct laser writing, two-photon polymerization, microfabrication, hydrogels, polyamino acids, poly(ethylene glycol) diacrylate",
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language = "English",
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Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization. / Käpylä, E. (Corresponding Author); Sedlacík, T.; Aydogan, D.B.; Viitanen, Jouko; Rypácek, F.; Kellomäki, M.

In: Materials Science and Engineering C: Materials for Biological Applications, Vol. 43, 2014, p. 280-289.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

AU - Käpylä, E.

AU - Sedlacík, T.

AU - Aydogan, D.B.

AU - Viitanen, Jouko

AU - Rypácek, F.

AU - Kellomäki, M.

PY - 2014

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AB - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

KW - direct laser writing

KW - two-photon polymerization

KW - microfabrication

KW - hydrogels

KW - polyamino acids

KW - poly(ethylene glycol) diacrylate

U2 - 10.1016/j.msec.2014.07.027

DO - 10.1016/j.msec.2014.07.027

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JO - Materials Science and Engineering C: Materials for Biological Applications

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