Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

E. Käpylä (Corresponding Author), T. Sedlacík, D.B. Aydogan, Jouko Viitanen, F. Rypácek, M. Kellomäki

Research output: Contribution to journalArticleScientificpeer-review

18 Citations (Scopus)

Abstract

The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(a-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.
Original languageEnglish
Pages (from-to)280-289
JournalMaterials Science and Engineering C: Materials for Biological Applications
Volume43
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

Keywords

  • direct laser writing
  • two-photon polymerization
  • microfabrication
  • hydrogels
  • polyamino acids
  • poly(ethylene glycol) diacrylate

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