Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms

Sanna Aikio (Corresponding Author), Martin Zeilinger, Jussi Hiltunen, Leena Hakalahti, Johanna Hiitola-Keinänen, Marianne Hiltunen, Ville Kontturi, Samuli Siitonen, Jarkko Puustinen, Peter Lieberzeit, Pentti Karioja

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Abstract

To enable wide spread dissemination of sensors in cost-critical applications and resource poor settings, methods to implement sensor chips using low-cost materials and mass-manufacturing methods are developed. In this paper we demonstrate that disposable polymeric integrated Young interferometer (YI) sensor chips, implemented on roll-to-roll mass-manufactured waveguides, are applicable for analyte specific sensing of small molecules and for multi-analyte detection of biomolecules. For the chemical sensing of small molecules, a sensor chip was functionalized with a molecularly imprinted polymer (MIP). We demonstrate that the MIP receptor layer is compatible with a polymer-based evanescent wave sensor for direct refractive index sensing. For multi-analyte detection of biomolecules, antibody-based receptor layers were patterned by inkjet printing onto the sensor surface demonstrating the applicability of the method with integrated YI chips. Demonstration of the analyte specific chemical- and biosensing with disposable polymeric YI sensor chips opens new possibilities to implement low-cost (bio)chemical sensors.
Original languageEnglish
Pages (from-to)50414-50422
JournalRSC Advances
Volume6
Issue number56
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

Fingerprint

Optical waveguides
Sensors
Interferometers
Polymers
Biomolecules
Costs
Molecules
Chemical sensors
Antibodies
Printing
Refractive index
Waveguides
Demonstrations

Keywords

  • biomolecules
  • chemical detection
  • chemical sensors
  • costs
  • molecules
  • polymers
  • refractive index
  • waveguides

Cite this

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title = "Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms",
abstract = "To enable wide spread dissemination of sensors in cost-critical applications and resource poor settings, methods to implement sensor chips using low-cost materials and mass-manufacturing methods are developed. In this paper we demonstrate that disposable polymeric integrated Young interferometer (YI) sensor chips, implemented on roll-to-roll mass-manufactured waveguides, are applicable for analyte specific sensing of small molecules and for multi-analyte detection of biomolecules. For the chemical sensing of small molecules, a sensor chip was functionalized with a molecularly imprinted polymer (MIP). We demonstrate that the MIP receptor layer is compatible with a polymer-based evanescent wave sensor for direct refractive index sensing. For multi-analyte detection of biomolecules, antibody-based receptor layers were patterned by inkjet printing onto the sensor surface demonstrating the applicability of the method with integrated YI chips. Demonstration of the analyte specific chemical- and biosensing with disposable polymeric YI sensor chips opens new possibilities to implement low-cost (bio)chemical sensors.",
keywords = "biomolecules, chemical detection, chemical sensors, costs, molecules, polymers, refractive index, waveguides",
author = "Sanna Aikio and Martin Zeilinger and Jussi Hiltunen and Leena Hakalahti and Johanna Hiitola-Kein{\"a}nen and Marianne Hiltunen and Ville Kontturi and Samuli Siitonen and Jarkko Puustinen and Peter Lieberzeit and Pentti Karioja",
year = "2016",
doi = "10.1039/c6ra07320d",
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Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms. / Aikio, Sanna (Corresponding Author); Zeilinger, Martin; Hiltunen, Jussi; Hakalahti, Leena; Hiitola-Keinänen, Johanna; Hiltunen, Marianne; Kontturi, Ville; Siitonen, Samuli; Puustinen, Jarkko; Lieberzeit, Peter; Karioja, Pentti.

In: RSC Advances, Vol. 6, No. 56, 2016, p. 50414-50422.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms

AU - Aikio, Sanna

AU - Zeilinger, Martin

AU - Hiltunen, Jussi

AU - Hakalahti, Leena

AU - Hiitola-Keinänen, Johanna

AU - Hiltunen, Marianne

AU - Kontturi, Ville

AU - Siitonen, Samuli

AU - Puustinen, Jarkko

AU - Lieberzeit, Peter

AU - Karioja, Pentti

PY - 2016

Y1 - 2016

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AB - To enable wide spread dissemination of sensors in cost-critical applications and resource poor settings, methods to implement sensor chips using low-cost materials and mass-manufacturing methods are developed. In this paper we demonstrate that disposable polymeric integrated Young interferometer (YI) sensor chips, implemented on roll-to-roll mass-manufactured waveguides, are applicable for analyte specific sensing of small molecules and for multi-analyte detection of biomolecules. For the chemical sensing of small molecules, a sensor chip was functionalized with a molecularly imprinted polymer (MIP). We demonstrate that the MIP receptor layer is compatible with a polymer-based evanescent wave sensor for direct refractive index sensing. For multi-analyte detection of biomolecules, antibody-based receptor layers were patterned by inkjet printing onto the sensor surface demonstrating the applicability of the method with integrated YI chips. Demonstration of the analyte specific chemical- and biosensing with disposable polymeric YI sensor chips opens new possibilities to implement low-cost (bio)chemical sensors.

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