Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms

Sanna Aikio (Corresponding Author), Martin Zeilinger, Jussi Hiltunen, Leena Hakalahti, Johanna Hiitola-Keinänen, Marianne Hiltunen, Ville Kontturi, Samuli Siitonen, Jarkko Puustinen, Peter Lieberzeit, Pentti Karioja

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Abstract

To enable wide spread dissemination of sensors in cost-critical applications and resource poor settings, methods to implement sensor chips using low-cost materials and mass-manufacturing methods are developed. In this paper we demonstrate that disposable polymeric integrated Young interferometer (YI) sensor chips, implemented on roll-to-roll mass-manufactured waveguides, are applicable for analyte specific sensing of small molecules and for multi-analyte detection of biomolecules. For the chemical sensing of small molecules, a sensor chip was functionalized with a molecularly imprinted polymer (MIP). We demonstrate that the MIP receptor layer is compatible with a polymer-based evanescent wave sensor for direct refractive index sensing. For multi-analyte detection of biomolecules, antibody-based receptor layers were patterned by inkjet printing onto the sensor surface demonstrating the applicability of the method with integrated YI chips. Demonstration of the analyte specific chemical- and biosensing with disposable polymeric YI sensor chips opens new possibilities to implement low-cost (bio)chemical sensors.
Original languageEnglish
Pages (from-to)50414-50422
JournalRSC Advances
Volume6
Issue number56
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

Keywords

  • biomolecules
  • chemical detection
  • chemical sensors
  • costs
  • molecules
  • polymers
  • refractive index
  • waveguides

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