Distance-controlled surface-enhanced Raman spectroscopy of nanoparticles

Duc Le (Corresponding Author), Martin Kögler, Tian Long Guo, Matthieu Roussey, Jussi Hiltunen

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)
34 Downloads (Pure)


Biological particles, e.g., viruses, lipid particles, and extracellular vesicles, are attracting significant research interest due to their role in biological processes and potential in practical applications, such as vaccines, diagnostics, and therapies. Their surface and interior contain many different molecules including lipids, nucleic acids, proteins, and carbohydrates. In this Letter, we show how distance-controlled surface-enhanced Raman spectroscopy (SERS) is a promising method to extract essential information from the spatial origin of the signal. This is a highly important parameter in the analysis of these biological particles. The principle of the method is demonstrated by using polystyrene (PS) beads as a biological particle model conjugated with gold nanospheres (AuNSs) functioning as distance-controlled SERS probes via biotin–streptavidin binding. By tuning the size of AuNSs, the Raman signal from the PS beads can be weakened while the signal from the biotin–streptavidin complex is enhanced.

Original languageEnglish
Pages (from-to)1454-1457
Number of pages4
JournalOptics Letters
Issue number6
Publication statusPublished - 15 Mar 2023
MoE publication typeA1 Journal article-refereed


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