Droserone from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and its biosynthetic origin

G. Bringmann (Corresponding Author), Heiko Rischer, M. Wohlfarth, J. Schlauer, L. Aké Assi

Research output: Contribution to journalArticleScientificpeer-review

40 Citations (Scopus)


The growth and droserone content of callus cultures of Triphyophyllum peltatum grown in liquid 1/5 Linsmaier and Skoog medium was studied. During a lag phase in growth, droserone concentrations in the medium reached a value of 2.1 mg g−1 fr. wt. After this maximum value the concentration decreased slightly to 1.8 mg g−1 fr. wt., while the growth of the calli was enhanced (25% increase in fr. wt. within 7 days). Plumbagin and isoshinanolone were likewise present in the medium. By feeding 13C2-labelled acetate to the cultures the biosynthesis of droserone was elucidated. The incorporation of whole C2-units unambiguously shows its acetogenic origin and fits well in the biosynthetic scheme suggested for the structurally — and biogenetically — related naphthylisoquinoline alkaloids.
Original languageEnglish
Pages (from-to)339-343
Number of pages5
Issue number3
Publication statusPublished - 2000
MoE publication typeNot Eligible


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