Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels

Hanna Valo, Suvi Arola, Päivi Laaksonen, Mika Torkkeli, Leena Peltonen, Markus Linder, Ritva Serimaa, Shigenori Kuga, Jouni Hirvonen, Timo Laaksonen (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

103 Citations (Scopus)

Abstract

Highly porous nanocellulose aerogels prepared by freeze-drying from various nanofibrillar cellulose (NFC) hydrogels are introduced as nanoparticle reservoirs for oral drug delivery systems. Here we show that beclomethasone dipropionate (BDP) nanoparticles coated with amphiphilic hydrophobin proteins can be well integrated into the NFC aerogels. NFCs from four different origins are introduced and compared to microcrystalline cellulose (MCC). The nanocellulose aerogel scaffolds made from red pepper (RC) and MCC release the drug immediately, while bacterial cellulose (BC), quince seed (QC) and TEMPO-oxidized birch cellulose-based (TC) aerogels show sustained drug release. Since the release of the drug is controlled by the structure and interactions between the nanoparticles and the cellulose matrix, modulation of the matrix formers enable a control of the drug release rate. These nanocomposite structures can be very useful in many pharmaceutical nanoparticle applications and open up new possibilities as carriers for controlled drug delivery.
Original languageEnglish
Pages (from-to)69-77
JournalEuropean Journal of Pharmaceutical Sciences
Volume50
Issue number1
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

Cellulose
Nanoparticles
oxidized cellulose
Rosaceae
Beclomethasone
Nanocomposites
Betula
Capsicum
Drug Carriers
Hydrogels
Freeze Drying
Drug Delivery Systems
Seeds
Drug Liberation
Pharmaceutical Preparations
Proteins
microcrystalline cellulose

Keywords

  • aerogel
  • bacterial cellulose
  • drug release
  • hydrophobin
  • naofibrillar cellulose
  • nanoparticles

Cite this

Valo, H., Arola, S., Laaksonen, P., Torkkeli, M., Peltonen, L., Linder, M., ... Laaksonen, T. (2013). Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels. European Journal of Pharmaceutical Sciences, 50(1), 69-77. https://doi.org/10.1016/j.ejps.2013.02.023
Valo, Hanna ; Arola, Suvi ; Laaksonen, Päivi ; Torkkeli, Mika ; Peltonen, Leena ; Linder, Markus ; Serimaa, Ritva ; Kuga, Shigenori ; Hirvonen, Jouni ; Laaksonen, Timo. / Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels. In: European Journal of Pharmaceutical Sciences. 2013 ; Vol. 50, No. 1. pp. 69-77.
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Valo, H, Arola, S, Laaksonen, P, Torkkeli, M, Peltonen, L, Linder, M, Serimaa, R, Kuga, S, Hirvonen, J & Laaksonen, T 2013, 'Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels', European Journal of Pharmaceutical Sciences, vol. 50, no. 1, pp. 69-77. https://doi.org/10.1016/j.ejps.2013.02.023

Drug release from nanoparticles embedded in four different nanofibrillar cellulose aerogels. / Valo, Hanna; Arola, Suvi; Laaksonen, Päivi; Torkkeli, Mika; Peltonen, Leena; Linder, Markus; Serimaa, Ritva; Kuga, Shigenori; Hirvonen, Jouni; Laaksonen, Timo (Corresponding Author).

In: European Journal of Pharmaceutical Sciences, Vol. 50, No. 1, 2013, p. 69-77.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Valo, Hanna

AU - Arola, Suvi

AU - Laaksonen, Päivi

AU - Torkkeli, Mika

AU - Peltonen, Leena

AU - Linder, Markus

AU - Serimaa, Ritva

AU - Kuga, Shigenori

AU - Hirvonen, Jouni

AU - Laaksonen, Timo

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AB - Highly porous nanocellulose aerogels prepared by freeze-drying from various nanofibrillar cellulose (NFC) hydrogels are introduced as nanoparticle reservoirs for oral drug delivery systems. Here we show that beclomethasone dipropionate (BDP) nanoparticles coated with amphiphilic hydrophobin proteins can be well integrated into the NFC aerogels. NFCs from four different origins are introduced and compared to microcrystalline cellulose (MCC). The nanocellulose aerogel scaffolds made from red pepper (RC) and MCC release the drug immediately, while bacterial cellulose (BC), quince seed (QC) and TEMPO-oxidized birch cellulose-based (TC) aerogels show sustained drug release. Since the release of the drug is controlled by the structure and interactions between the nanoparticles and the cellulose matrix, modulation of the matrix formers enable a control of the drug release rate. These nanocomposite structures can be very useful in many pharmaceutical nanoparticle applications and open up new possibilities as carriers for controlled drug delivery.

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