Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation

Juha Koikkalainen; Mervi Könönen; Jari Karhu; Jarmo Ruohonen; Eini Niskanen; Jyrki Lötjönen

doi:10.1007/978-3-540-85988-8_65

Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation

Juha Koikkalainen, Mervi Könönen, Jari Karhu, Jarmo Ruohonen, Eini Niskanen, Jyrki Lötjönen

VTT Technical Research Centre of Finland

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

2 Citations (Scopus)

Abstract

Transcranial Magnetic Stimulation (TMS) is a technique to stimulate the brain non-invasively. The applications range from accurate localization of the primary motor areas to potential treatment of disorders such as tinnitus, severe depression, and pain. Stereotactic guidance requires individual MR images of the subject's head, which is in some applications typically omitted due to financial motivations. In this paper, we introduce a method that offers improved TMS pulse targeting also to those subjects who do not have MR examinations. A probabilistic brain model was constructed by spatially normalizing the locations of the functional brain areas in a study population, and modeling the distributions and estimates of the locations of the functional brain regions using probabilistic methods. The application of the probabilistic brain model to the target subject was based on a point set determined from the scalp and facial skin of the target subject. The methods were evaluated using data from four functional brain areas from 56 healthy subjects. The accuracy of the estimates of the locations of the functional brain regions was about nine millimeters.

Original language	English
Title of host publication	Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008
Editors	D. Metaxas, L. Axel, G. Fichtinger, G. Székely
Place of Publication	Berlin
Publisher	Springer
Pages	543-550
ISBN (Electronic)	978-3-5408-5988-8
ISBN (Print)	978-3-5408-5987-1
DOIs	https://doi.org/10.1007/978-3-540-85988-8_65
Publication status	Published - 2008
MoE publication type	A4 Article in a conference publication
Event	International Conference on Medical Image Computing and Computer-Assisted Intervention - New York, United States Duration: 6 Sept 2008 → 10 Sept 2008

Publication series

Series	Lecture Notes in Computer Science
Volume	5241
ISSN	0302-9743

Conference

Conference	International Conference on Medical Image Computing and Computer-Assisted Intervention
Country/Territory	United States
City	New York
Period	6/09/08 → 10/09/08

Keywords

TMS
functional atlas
point-based registration

Access to Document

10.1007/978-3-540-85988-8_65

Cite this

Koikkalainen, J., Könönen, M., Karhu, J., Ruohonen, J., Niskanen, E., & Lötjönen, J. (2008). Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation. In D. Metaxas, L. Axel, G. Fichtinger, & G. Székely (Eds.), Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 (pp. 543-550). Springer. https://doi.org/10.1007/978-3-540-85988-8_65

Koikkalainen, Juha ; Könönen, Mervi ; Karhu, Jari et al. / Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008. editor / D. Metaxas ; L. Axel ; G. Fichtinger ; G. Székely. Berlin : Springer, 2008. pp. 543-550 (Lecture Notes in Computer Science, Vol. 5241).

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abstract = "Transcranial Magnetic Stimulation (TMS) is a technique to stimulate the brain non-invasively. The applications range from accurate localization of the primary motor areas to potential treatment of disorders such as tinnitus, severe depression, and pain. Stereotactic guidance requires individual MR images of the subject's head, which is in some applications typically omitted due to financial motivations. In this paper, we introduce a method that offers improved TMS pulse targeting also to those subjects who do not have MR examinations. A probabilistic brain model was constructed by spatially normalizing the locations of the functional brain areas in a study population, and modeling the distributions and estimates of the locations of the functional brain regions using probabilistic methods. The application of the probabilistic brain model to the target subject was based on a point set determined from the scalp and facial skin of the target subject. The methods were evaluated using data from four functional brain areas from 56 healthy subjects. The accuracy of the estimates of the locations of the functional brain regions was about nine millimeters.",

keywords = "TMS, functional atlas, point-based registration",

author = "Juha Koikkalainen and Mervi K{\"o}n{\"o}nen and Jari Karhu and Jarmo Ruohonen and Eini Niskanen and Jyrki L{\"o}tj{\"o}nen",

note = "Project code: 22601; International Conference on Medical Image Computing and Computer-Assisted Intervention ; Conference date: 06-09-2008 Through 10-09-2008",

year = "2008",

doi = "10.1007/978-3-540-85988-8_65",

language = "English",

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series = "Lecture Notes in Computer Science",

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Koikkalainen, J, Könönen, M, Karhu, J, Ruohonen, J, Niskanen, E & Lötjönen, J 2008, Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation. in D Metaxas, L Axel, G Fichtinger & G Székely (eds), Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008. Springer, Berlin, Lecture Notes in Computer Science, vol. 5241, pp. 543-550, International Conference on Medical Image Computing and Computer-Assisted Intervention, New York, United States, 6/09/08. https://doi.org/10.1007/978-3-540-85988-8_65

Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation. / Koikkalainen, Juha; Könönen, Mervi; Karhu, Jari et al.
Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008. ed. / D. Metaxas; L. Axel; G. Fichtinger; G. Székely. Berlin: Springer, 2008. p. 543-550 (Lecture Notes in Computer Science, Vol. 5241).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation

AU - Koikkalainen, Juha

AU - Könönen, Mervi

AU - Karhu, Jari

AU - Ruohonen, Jarmo

AU - Niskanen, Eini

AU - Lötjönen, Jyrki

N1 - Project code: 22601

PY - 2008

Y1 - 2008

N2 - Transcranial Magnetic Stimulation (TMS) is a technique to stimulate the brain non-invasively. The applications range from accurate localization of the primary motor areas to potential treatment of disorders such as tinnitus, severe depression, and pain. Stereotactic guidance requires individual MR images of the subject's head, which is in some applications typically omitted due to financial motivations. In this paper, we introduce a method that offers improved TMS pulse targeting also to those subjects who do not have MR examinations. A probabilistic brain model was constructed by spatially normalizing the locations of the functional brain areas in a study population, and modeling the distributions and estimates of the locations of the functional brain regions using probabilistic methods. The application of the probabilistic brain model to the target subject was based on a point set determined from the scalp and facial skin of the target subject. The methods were evaluated using data from four functional brain areas from 56 healthy subjects. The accuracy of the estimates of the locations of the functional brain regions was about nine millimeters.

AB - Transcranial Magnetic Stimulation (TMS) is a technique to stimulate the brain non-invasively. The applications range from accurate localization of the primary motor areas to potential treatment of disorders such as tinnitus, severe depression, and pain. Stereotactic guidance requires individual MR images of the subject's head, which is in some applications typically omitted due to financial motivations. In this paper, we introduce a method that offers improved TMS pulse targeting also to those subjects who do not have MR examinations. A probabilistic brain model was constructed by spatially normalizing the locations of the functional brain areas in a study population, and modeling the distributions and estimates of the locations of the functional brain regions using probabilistic methods. The application of the probabilistic brain model to the target subject was based on a point set determined from the scalp and facial skin of the target subject. The methods were evaluated using data from four functional brain areas from 56 healthy subjects. The accuracy of the estimates of the locations of the functional brain regions was about nine millimeters.

KW - TMS

KW - functional atlas

KW - point-based registration

U2 - 10.1007/978-3-540-85988-8_65

DO - 10.1007/978-3-540-85988-8_65

M3 - Conference article in proceedings

SN - 978-3-5408-5987-1

T3 - Lecture Notes in Computer Science

SP - 543

EP - 550

BT - Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008

A2 - Metaxas, D.

A2 - Axel, L.

A2 - Fichtinger, G.

A2 - Székely, G.

PB - Springer

CY - Berlin

T2 - International Conference on Medical Image Computing and Computer-Assisted Intervention

Y2 - 6 September 2008 through 10 September 2008

ER -

Koikkalainen J, Könönen M, Karhu J, Ruohonen J, Niskanen E, Lötjönen J. Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation. In Metaxas D, Axel L, Fichtinger G, Székely G, editors, Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008. Berlin: Springer. 2008. p. 543-550. (Lecture Notes in Computer Science, Vol. 5241). doi: 10.1007/978-3-540-85988-8_65

Dynamic probabilistic atlas of functional brain regions for transcranial magnetic stimulation

Abstract

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Keywords

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