Abstract
The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107 patients with mTBI (Glasgow Coma Scale ≥13) who had blood samples for GFAP and NF-L available within 24 h of arrival were included. Patients with mTBI were divided into computed tomography (CT)-positive and CT-negative groups. Glasgow Outcome Scale-Extended (GOSE) was used to assess the outcome. Outcomes were defined as complete (GOSE 8) versus incomplete (GOSE <8), and favorable (GOSE 5-8) versus unfavorable (GOSE 1-4). GFAP and NF-L concentrations in blood were measured using ultrasensitive single molecule array technology. Patients with incomplete recovery had significantly higher levels of NF-L compared with those with complete recovery (p = 0.005). The levels of GFAP and NF-L were significantly higher in patients with unfavorable outcome than in patients with favorable outcome (p = 0.002 for GFAP and p < 0.001 for NF-L). For predicting favorable outcome, the area under the receiver operating characteristic curve for GFAP and NF-L was 0.755 and 0.826, respectively. In a multi-variate logistic regression model, the level of NF-L was still a significant predictor for complete recovery (odds ratio [OR] = 1.008; 95% confidence interval [CI], 1.000-1.016). Moreover, the level of NF-L was a significant predictor for complete recovery in CT-positive patients (OR = 1.009; 95% CI, 1.001-1.016). The early levels of GFAP and NF-L are significantly correlated with the outcome in patients with mTBI. The level of NF-L within 24 h from arrival has a significant predictive value in mTBI also in a multi-variate model.
| Original language | English |
|---|---|
| Pages (from-to) | 1551-1560 |
| Journal | Journal of Neurotrauma |
| Volume | 36 |
| Issue number | 10 |
| Early online date | 8 Jan 2019 |
| DOIs | |
| Publication status | Published - 15 May 2019 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- biomarkes
- traumatic brain injury
- outcome measures
Cite this
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Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury. / Hossain, Iftakher (Corresponding Author); Mohammadian, Mehrbod; Takala, Riikka S.K.; Tenovuo, Olli; Lagerstedt, Linnéa; Ala-Seppälä, Henna Maria; Frantzén, Janek; van Gils, Mark; Hutchinson, Peter John; Katila, Ari J.; Maanpää, Henna-Riikka; Menon, David; Newcombe, Virginia; Tallus, Jussi; Hrusovsky, Kevin; Wilson, David; Blennow, Kaj; Sanchez, Jean-Charles; Zetterberg, Henrik; Posti, Jussi P.
In: Journal of Neurotrauma, Vol. 36, No. 10, 15.05.2019, p. 1551-1560.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Early Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein in Predicting the Outcome of Mild Traumatic Brain Injury
AU - Hossain, Iftakher
AU - Mohammadian, Mehrbod
AU - Takala, Riikka S.K.
AU - Tenovuo, Olli
AU - Lagerstedt, Linnéa
AU - Ala-Seppälä, Henna Maria
AU - Frantzén, Janek
AU - van Gils, Mark
AU - Hutchinson, Peter John
AU - Katila, Ari J.
AU - Maanpää, Henna-Riikka
AU - Menon, David
AU - Newcombe, Virginia
AU - Tallus, Jussi
AU - Hrusovsky, Kevin
AU - Wilson, David
AU - Blennow, Kaj
AU - Sanchez, Jean-Charles
AU - Zetterberg, Henrik
AU - Posti, Jussi P.
PY - 2019/5/15
Y1 - 2019/5/15
N2 - The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107 patients with mTBI (Glasgow Coma Scale ≥13) who had blood samples for GFAP and NF-L available within 24 h of arrival were included. Patients with mTBI were divided into computed tomography (CT)-positive and CT-negative groups. Glasgow Outcome Scale-Extended (GOSE) was used to assess the outcome. Outcomes were defined as complete (GOSE 8) versus incomplete (GOSE <8), and favorable (GOSE 5-8) versus unfavorable (GOSE 1-4). GFAP and NF-L concentrations in blood were measured using ultrasensitive single molecule array technology. Patients with incomplete recovery had significantly higher levels of NF-L compared with those with complete recovery (p = 0.005). The levels of GFAP and NF-L were significantly higher in patients with unfavorable outcome than in patients with favorable outcome (p = 0.002 for GFAP and p < 0.001 for NF-L). For predicting favorable outcome, the area under the receiver operating characteristic curve for GFAP and NF-L was 0.755 and 0.826, respectively. In a multi-variate logistic regression model, the level of NF-L was still a significant predictor for complete recovery (odds ratio [OR] = 1.008; 95% confidence interval [CI], 1.000-1.016). Moreover, the level of NF-L was a significant predictor for complete recovery in CT-positive patients (OR = 1.009; 95% CI, 1.001-1.016). The early levels of GFAP and NF-L are significantly correlated with the outcome in patients with mTBI. The level of NF-L within 24 h from arrival has a significant predictive value in mTBI also in a multi-variate model.
AB - The purpose of this study was to correlate the early levels of glial fibrillary acidic protein (GFAP) and neurofilament light protein (NF-L) with outcome in patients with mild traumatic brain injury (mTBI). A total of 107 patients with mTBI (Glasgow Coma Scale ≥13) who had blood samples for GFAP and NF-L available within 24 h of arrival were included. Patients with mTBI were divided into computed tomography (CT)-positive and CT-negative groups. Glasgow Outcome Scale-Extended (GOSE) was used to assess the outcome. Outcomes were defined as complete (GOSE 8) versus incomplete (GOSE <8), and favorable (GOSE 5-8) versus unfavorable (GOSE 1-4). GFAP and NF-L concentrations in blood were measured using ultrasensitive single molecule array technology. Patients with incomplete recovery had significantly higher levels of NF-L compared with those with complete recovery (p = 0.005). The levels of GFAP and NF-L were significantly higher in patients with unfavorable outcome than in patients with favorable outcome (p = 0.002 for GFAP and p < 0.001 for NF-L). For predicting favorable outcome, the area under the receiver operating characteristic curve for GFAP and NF-L was 0.755 and 0.826, respectively. In a multi-variate logistic regression model, the level of NF-L was still a significant predictor for complete recovery (odds ratio [OR] = 1.008; 95% confidence interval [CI], 1.000-1.016). Moreover, the level of NF-L was a significant predictor for complete recovery in CT-positive patients (OR = 1.009; 95% CI, 1.001-1.016). The early levels of GFAP and NF-L are significantly correlated with the outcome in patients with mTBI. The level of NF-L within 24 h from arrival has a significant predictive value in mTBI also in a multi-variate model.
KW - biomarkes
KW - traumatic brain injury
KW - outcome measures
UR - http://www.scopus.com/inward/record.url?scp=85065528940&partnerID=8YFLogxK
U2 - 10.1089/NEU.2018.5952
DO - 10.1089/NEU.2018.5952
M3 - Article
VL - 36
SP - 1551
EP - 1560
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
SN - 0897-7151
IS - 10
ER -