Early transition metal (group 3-5, lanthanides and actinides) and main group metal (group 1, 2, and 13) catalyzed hydroamination

Alexander L. Reznichenko, Kai C. Hultzsch

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

74 Citations (Scopus)

Abstract

The hydroamination of alkenes, dienes, allenes, and alkynes by early transition metal catalysts has seen significant progress over the last decade, especially with respect to control of regio- and stereoselectivity and the synthesis of more complex nitrogen-containing skeletons. This article provides an overview over the application of catalyst systems based on the 17 rare earth elements, as well as group 4 and group 5 metals. These electropositive metal catalysts operate via activation of the amine to form catalytic active metal-amido or metal-imido species, although the true nature of this species is not known with certainty for all systems and may vary for different substrate classes. This mode of activation differentiates early transition metal catalysts from many late transition metal catalysts that operate via activation of the unsaturated C-C linkage (alkene, 1,3-diene, allene, or alkyne). Alkali metals, alkaline earth metals and aluminum are included in this overview as well, as they show strong similarities in their reactivity and mechanistic pathways to aforementioned early transition metals. While the structure-reactivity principles are well understood for certain hydroamination processes, e.g., in the intramolecular hydroamination of aminoalkenes or the intermolecular hydroamination of alkynes, other transformations, in particular the intermolecular hydroamination of alkenes, remain highly challenging. Due to the potential of the hydroamination process for the synthesis of pharmaceuticals and other industrially relevant fine chemicals, a strong emphasis is given on the application of chiral catalysts in stereoselective processes.

Original languageEnglish
Title of host publicationHydrofunctionalization
EditorsValentine P. Ananikov, Masato Tanaka
PublisherSpringer
Pages51-114
Number of pages64
ISBN (Print)978-364233734-5
DOIs
Publication statusPublished - 2013
MoE publication typeA3 Part of a book or another research book

Publication series

SeriesTopics in Organometallic Chemistry
Volume43
ISSN1436-6002

Keywords

  • Alkali metals
  • Alkaline earth metals
  • Aluminum
  • Asymmetric synthesis
  • Catalysis
  • Group 4 metals
  • Group 5 metals
  • Hydroamination
  • Rare earth metals

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