Effect of age and body weight on neurohumoral variables in healthy Cavalier King Charles spaniels

A.S. Eriksson, A.K. Järvinen, K.K. Eklund, O.J. Vuolteenaho, Mervi Toivari, M.S. Nieminen

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Abstract

Objective — To evaluate the effect of age and body weight on several neurohumoral variables that are commonly altered in heart failure in Cavalier King Charles Spaniels.

Animals — 17 healthy privately owned Cavalier King Charles Spaniels, 10 males and 7 females, ranging in age from 0.4 to 9.7 years, and ranging in body weight from 6.6 to 12.2 kg.

Procedure — The clinical condition of the dogs was evaluated by physical examination, thoracic radiography, and echocardiography. Plasma nitrate and nitrite (P-NN), N-terminal atrial natriuretic and brain natriuretic peptides (NT-ANP and BNP, respectively), endothelin (ET-1), urine cyclic guanosine monophosphate (UcGMP), and urine nitrate and nitrite (U-NN) concentrations were analyzed.

Results — Plasma concentrations of NT-ANP and P-NN increased significantly with age, but plasma NT-ANP and P-NN also correlated significantly, irrespective of age. A modest increase of left atrial size did not explain the increase of NT-ANP and P-NN with age. Concentration of ET-1 correlated positively with heart rate; heart rate did not change with age. Weight had a negative impact on NT-ANP, P-NN, and U-cGMP concentrations and left atrial relative size.

Conclusions and Clinical Relevance — Age-matched controls are essential for evaluation of NT-ANP and PNN concentrations and left atrial size. Weight may alter reference values of plasma NT-ANP, P-NN, and urine cGMP concentrations. Natriuretic peptides can be used as further evidence that heart failure exists. The increased plasma concentrations of NT-ANP (but not BNP) and P-NN with aging reflect neurohumoral physiologic changes that must be distinguished from pathologic changes in patients with heart failure.
Original languageEnglish
Pages (from-to)1818-1824
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume62
Issue number11
DOIs
Publication statusPublished - 2001
MoE publication typeA1 Journal article-refereed

Fingerprint

nitrites
Atrial Natriuretic Factor
Nitrites
Body Weight
nitrates
Nitrates
body weight
heart failure
natriuretic peptides
urine
heart rate
Heart Failure
Urine
guanosine monophosphate
nitrite nitrogen
endothelins
Cavalier King Charles Spaniel
Thoracic Radiography
echocardiography
Heart Rate

Cite this

Eriksson, A.S. ; Järvinen, A.K. ; Eklund, K.K. ; Vuolteenaho, O.J. ; Toivari, Mervi ; Nieminen, M.S. / Effect of age and body weight on neurohumoral variables in healthy Cavalier King Charles spaniels. In: American Journal of Veterinary Research. 2001 ; Vol. 62, No. 11. pp. 1818-1824.
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title = "Effect of age and body weight on neurohumoral variables in healthy Cavalier King Charles spaniels",
abstract = "Objective — To evaluate the effect of age and body weight on several neurohumoral variables that are commonly altered in heart failure in Cavalier King Charles Spaniels.Animals — 17 healthy privately owned Cavalier King Charles Spaniels, 10 males and 7 females, ranging in age from 0.4 to 9.7 years, and ranging in body weight from 6.6 to 12.2 kg.Procedure — The clinical condition of the dogs was evaluated by physical examination, thoracic radiography, and echocardiography. Plasma nitrate and nitrite (P-NN), N-terminal atrial natriuretic and brain natriuretic peptides (NT-ANP and BNP, respectively), endothelin (ET-1), urine cyclic guanosine monophosphate (UcGMP), and urine nitrate and nitrite (U-NN) concentrations were analyzed.Results — Plasma concentrations of NT-ANP and P-NN increased significantly with age, but plasma NT-ANP and P-NN also correlated significantly, irrespective of age. A modest increase of left atrial size did not explain the increase of NT-ANP and P-NN with age. Concentration of ET-1 correlated positively with heart rate; heart rate did not change with age. Weight had a negative impact on NT-ANP, P-NN, and U-cGMP concentrations and left atrial relative size.Conclusions and Clinical Relevance — Age-matched controls are essential for evaluation of NT-ANP and PNN concentrations and left atrial size. Weight may alter reference values of plasma NT-ANP, P-NN, and urine cGMP concentrations. Natriuretic peptides can be used as further evidence that heart failure exists. The increased plasma concentrations of NT-ANP (but not BNP) and P-NN with aging reflect neurohumoral physiologic changes that must be distinguished from pathologic changes in patients with heart failure.",
author = "A.S. Eriksson and A.K. J{\"a}rvinen and K.K. Eklund and O.J. Vuolteenaho and Mervi Toivari and M.S. Nieminen",
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doi = "10.2460/ajvr.2001.62.1818",
language = "English",
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Effect of age and body weight on neurohumoral variables in healthy Cavalier King Charles spaniels. / Eriksson, A.S.; Järvinen, A.K.; Eklund, K.K.; Vuolteenaho, O.J.; Toivari, Mervi; Nieminen, M.S.

In: American Journal of Veterinary Research, Vol. 62, No. 11, 2001, p. 1818-1824.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Effect of age and body weight on neurohumoral variables in healthy Cavalier King Charles spaniels

AU - Eriksson, A.S.

AU - Järvinen, A.K.

AU - Eklund, K.K.

AU - Vuolteenaho, O.J.

AU - Toivari, Mervi

AU - Nieminen, M.S.

PY - 2001

Y1 - 2001

N2 - Objective — To evaluate the effect of age and body weight on several neurohumoral variables that are commonly altered in heart failure in Cavalier King Charles Spaniels.Animals — 17 healthy privately owned Cavalier King Charles Spaniels, 10 males and 7 females, ranging in age from 0.4 to 9.7 years, and ranging in body weight from 6.6 to 12.2 kg.Procedure — The clinical condition of the dogs was evaluated by physical examination, thoracic radiography, and echocardiography. Plasma nitrate and nitrite (P-NN), N-terminal atrial natriuretic and brain natriuretic peptides (NT-ANP and BNP, respectively), endothelin (ET-1), urine cyclic guanosine monophosphate (UcGMP), and urine nitrate and nitrite (U-NN) concentrations were analyzed.Results — Plasma concentrations of NT-ANP and P-NN increased significantly with age, but plasma NT-ANP and P-NN also correlated significantly, irrespective of age. A modest increase of left atrial size did not explain the increase of NT-ANP and P-NN with age. Concentration of ET-1 correlated positively with heart rate; heart rate did not change with age. Weight had a negative impact on NT-ANP, P-NN, and U-cGMP concentrations and left atrial relative size.Conclusions and Clinical Relevance — Age-matched controls are essential for evaluation of NT-ANP and PNN concentrations and left atrial size. Weight may alter reference values of plasma NT-ANP, P-NN, and urine cGMP concentrations. Natriuretic peptides can be used as further evidence that heart failure exists. The increased plasma concentrations of NT-ANP (but not BNP) and P-NN with aging reflect neurohumoral physiologic changes that must be distinguished from pathologic changes in patients with heart failure.

AB - Objective — To evaluate the effect of age and body weight on several neurohumoral variables that are commonly altered in heart failure in Cavalier King Charles Spaniels.Animals — 17 healthy privately owned Cavalier King Charles Spaniels, 10 males and 7 females, ranging in age from 0.4 to 9.7 years, and ranging in body weight from 6.6 to 12.2 kg.Procedure — The clinical condition of the dogs was evaluated by physical examination, thoracic radiography, and echocardiography. Plasma nitrate and nitrite (P-NN), N-terminal atrial natriuretic and brain natriuretic peptides (NT-ANP and BNP, respectively), endothelin (ET-1), urine cyclic guanosine monophosphate (UcGMP), and urine nitrate and nitrite (U-NN) concentrations were analyzed.Results — Plasma concentrations of NT-ANP and P-NN increased significantly with age, but plasma NT-ANP and P-NN also correlated significantly, irrespective of age. A modest increase of left atrial size did not explain the increase of NT-ANP and P-NN with age. Concentration of ET-1 correlated positively with heart rate; heart rate did not change with age. Weight had a negative impact on NT-ANP, P-NN, and U-cGMP concentrations and left atrial relative size.Conclusions and Clinical Relevance — Age-matched controls are essential for evaluation of NT-ANP and PNN concentrations and left atrial size. Weight may alter reference values of plasma NT-ANP, P-NN, and urine cGMP concentrations. Natriuretic peptides can be used as further evidence that heart failure exists. The increased plasma concentrations of NT-ANP (but not BNP) and P-NN with aging reflect neurohumoral physiologic changes that must be distinguished from pathologic changes in patients with heart failure.

U2 - 10.2460/ajvr.2001.62.1818

DO - 10.2460/ajvr.2001.62.1818

M3 - Article

VL - 62

SP - 1818

EP - 1824

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 11

ER -