Effect of galacto-oligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis Bb-12 in the gastrointestinal tract

Minna Alander, Jaana Mättö, W. Kneifel, M. Johansson, B. Kögler, Ross Crittenden, Tiina Mattila-Sandholm, Maria Saarela (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Galacto-oligosaccharides (GOS) are considered to have bifidogenic properties in humans. To study the effect of GOS-containing syrup (60% GOS) alone or together with the probiotic strain Bifidobacterium lactis Bb-12 on selected components of the faecal flora, and the effect of GOS supplementation on colonisation of B. lactis Bb-12, a feeding trial on 30 healthy volunteers was performed. Mean numbers of bifidobacteria increased slightly in all study groups during the feeding period. Isolates having the identical RAPD genotype with B. lactis Bb-12 were detected in high numbers in the Bb-12 group and in the GOS-containing syrup+Bb-12 group indicating a good survival of B. lactis Bb-12 through the gastrointestinal tract. No differences in the prevalence or numbers of isolates with B. lactis Bb-12 genotype could be observed between groups suggesting that GOS-containing syrup did not enhance the survival or persistence of B. lactis Bb-12 in the gut.
Original languageEnglish
Pages (from-to)817-825
Number of pages9
JournalInternational Dairy Journal
Volume11
Issue number10
DOIs
Publication statusPublished - 2001
MoE publication typeA1 Journal article-refereed

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galactooligosaccharides
Oligosaccharides
gastrointestinal system
Gastrointestinal Tract
microorganisms
Survival
syrups
Genotype
Bifidobacterium
genotype
Probiotics
probiotics
volunteers
Bifidobacterium animalis subsp. lactis
Bifidobacterium animalis
Healthy Volunteers
digestive system
flora

Cite this

Alander, Minna ; Mättö, Jaana ; Kneifel, W. ; Johansson, M. ; Kögler, B. ; Crittenden, Ross ; Mattila-Sandholm, Tiina ; Saarela, Maria. / Effect of galacto-oligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis Bb-12 in the gastrointestinal tract. In: International Dairy Journal. 2001 ; Vol. 11, No. 10. pp. 817-825.
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abstract = "Galacto-oligosaccharides (GOS) are considered to have bifidogenic properties in humans. To study the effect of GOS-containing syrup (60{\%} GOS) alone or together with the probiotic strain Bifidobacterium lactis Bb-12 on selected components of the faecal flora, and the effect of GOS supplementation on colonisation of B. lactis Bb-12, a feeding trial on 30 healthy volunteers was performed. Mean numbers of bifidobacteria increased slightly in all study groups during the feeding period. Isolates having the identical RAPD genotype with B. lactis Bb-12 were detected in high numbers in the Bb-12 group and in the GOS-containing syrup+Bb-12 group indicating a good survival of B. lactis Bb-12 through the gastrointestinal tract. No differences in the prevalence or numbers of isolates with B. lactis Bb-12 genotype could be observed between groups suggesting that GOS-containing syrup did not enhance the survival or persistence of B. lactis Bb-12 in the gut.",
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Effect of galacto-oligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis Bb-12 in the gastrointestinal tract. / Alander, Minna; Mättö, Jaana; Kneifel, W.; Johansson, M.; Kögler, B.; Crittenden, Ross; Mattila-Sandholm, Tiina; Saarela, Maria (Corresponding Author).

In: International Dairy Journal, Vol. 11, No. 10, 2001, p. 817-825.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Effect of galacto-oligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis Bb-12 in the gastrointestinal tract

AU - Alander, Minna

AU - Mättö, Jaana

AU - Kneifel, W.

AU - Johansson, M.

AU - Kögler, B.

AU - Crittenden, Ross

AU - Mattila-Sandholm, Tiina

AU - Saarela, Maria

PY - 2001

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AB - Galacto-oligosaccharides (GOS) are considered to have bifidogenic properties in humans. To study the effect of GOS-containing syrup (60% GOS) alone or together with the probiotic strain Bifidobacterium lactis Bb-12 on selected components of the faecal flora, and the effect of GOS supplementation on colonisation of B. lactis Bb-12, a feeding trial on 30 healthy volunteers was performed. Mean numbers of bifidobacteria increased slightly in all study groups during the feeding period. Isolates having the identical RAPD genotype with B. lactis Bb-12 were detected in high numbers in the Bb-12 group and in the GOS-containing syrup+Bb-12 group indicating a good survival of B. lactis Bb-12 through the gastrointestinal tract. No differences in the prevalence or numbers of isolates with B. lactis Bb-12 genotype could be observed between groups suggesting that GOS-containing syrup did not enhance the survival or persistence of B. lactis Bb-12 in the gut.

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