Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults

Riina A. Kekkonen, Marko Sysi-Aho, Tuulikki Seppänen-Laakso, Ilkka Julkunen, Heikki Vapaatalo, Matej Orešič, Riitta Korpela (Corresponding Author)

    Research output: Contribution to journalArticleScientificpeer-review

    62 Citations (Scopus)


    AIM: To investigate the effect of three weeks’ intervention with a probiotic Lactobacillus rhamnosus GG (LGG) bacteria on global serum lipidomic profiles and evaluate whether the changes in inflammatory variables (CRP, TNF-α and IL-6) are reflected in the global lipidomic profiles of healthy adults.

    METHODS: We performed UPLC/MS-based global lipidomic platform analysis of serum samples (n = 26) in a substudy of a randomised, double-blind, placebo-controlled 3-wk clinical intervention trial investigating the immunomodulatory effects of probiotics in healthy adults.

    RESULTS: A total of 407 lipids were identified, corresponding to 13 different lipid classes. Serum samples showed decreases in the levels of lysophosphatidylcholines (LysoGPCho), sphingomyelins (SM) and several glycerophosphatidylcholines (GPCho), while triacylglycerols (TAG) were mainly increased in the probiotic LGG group during the intervention. Among the inflammatory variables, IL-6 was moderately associated by changes in global lipidomic profiles, with the top-ranked lipid associated with IL-6 being the proinflammatory LysoGPCho (20:4). There was a weak association between the lipidomic profiles and the two other inflammatory markers, TNF-α and CRP.

    CONCLUSION: This was the first study to investigate the effects of probiotic intervention on global lipidomic profiles in humans. There are indications that probiotic LGG intervention may lead to changes in serum global lipid profiles, as reflected in decreased GPCho, LysoGPCho and SM as well as mainly increased TAG.

    Original languageEnglish
    Pages (from-to)3188 - 3194
    Number of pages7
    JournalWorld Journal of Gastroenterology
    Issue number20
    Publication statusPublished - 2008
    MoE publication typeA1 Journal article-refereed


    • Probiotic
    • Lactobacillus rhamnosus GG
    • Lipidomic
    • Inflammatory mediators
    • Healthy adults


    Dive into the research topics of 'Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults'. Together they form a unique fingerprint.

    Cite this