Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults

Riina A. Kekkonen, Marko Sysi-Aho, Tuulikki Seppänen-Laakso, Ilkka Julkunen, Heikki Vapaatalo, Matej Orešič, Riitta Korpela (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

52 Citations (Scopus)

Abstract

AIM: To investigate the effect of three weeks’ intervention with a probiotic Lactobacillus rhamnosus GG (LGG) bacteria on global serum lipidomic profiles and evaluate whether the changes in inflammatory variables (CRP, TNF-α and IL-6) are reflected in the global lipidomic profiles of healthy adults.

METHODS: We performed UPLC/MS-based global lipidomic platform analysis of serum samples (n = 26) in a substudy of a randomised, double-blind, placebo-controlled 3-wk clinical intervention trial investigating the immunomodulatory effects of probiotics in healthy adults.

RESULTS: A total of 407 lipids were identified, corresponding to 13 different lipid classes. Serum samples showed decreases in the levels of lysophosphatidylcholines (LysoGPCho), sphingomyelins (SM) and several glycerophosphatidylcholines (GPCho), while triacylglycerols (TAG) were mainly increased in the probiotic LGG group during the intervention. Among the inflammatory variables, IL-6 was moderately associated by changes in global lipidomic profiles, with the top-ranked lipid associated with IL-6 being the proinflammatory LysoGPCho (20:4). There was a weak association between the lipidomic profiles and the two other inflammatory markers, TNF-α and CRP.

CONCLUSION: This was the first study to investigate the effects of probiotic intervention on global lipidomic profiles in humans. There are indications that probiotic LGG intervention may lead to changes in serum global lipid profiles, as reflected in decreased GPCho, LysoGPCho and SM as well as mainly increased TAG.

Original languageEnglish
Pages (from-to)3188 - 3194
Number of pages7
JournalWorld Journal of Gastroenterology
Volume14
Issue number20
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Fingerprint

Lactobacillus rhamnosus
Probiotics
Serum
Lipids
Interleukin-6
Sphingomyelins
Triglycerides
Lysophosphatidylcholines
Placebos
Clinical Trials
Bacteria

Keywords

  • Probiotic
  • Lactobacillus rhamnosus GG
  • Lipidomic
  • Inflammatory mediators
  • Healthy adults

Cite this

Kekkonen, Riina A. ; Sysi-Aho, Marko ; Seppänen-Laakso, Tuulikki ; Julkunen, Ilkka ; Vapaatalo, Heikki ; Orešič, Matej ; Korpela, Riitta. / Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults. In: World Journal of Gastroenterology. 2008 ; Vol. 14, No. 20. pp. 3188 - 3194.
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Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults. / Kekkonen, Riina A.; Sysi-Aho, Marko; Seppänen-Laakso, Tuulikki; Julkunen, Ilkka; Vapaatalo, Heikki; Orešič, Matej; Korpela, Riitta (Corresponding Author).

In: World Journal of Gastroenterology, Vol. 14, No. 20, 2008, p. 3188 - 3194.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults

AU - Kekkonen, Riina A.

AU - Sysi-Aho, Marko

AU - Seppänen-Laakso, Tuulikki

AU - Julkunen, Ilkka

AU - Vapaatalo, Heikki

AU - Orešič, Matej

AU - Korpela, Riitta

PY - 2008

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N2 - AIM: To investigate the effect of three weeks’ intervention with a probiotic Lactobacillus rhamnosus GG (LGG) bacteria on global serum lipidomic profiles and evaluate whether the changes in inflammatory variables (CRP, TNF-α and IL-6) are reflected in the global lipidomic profiles of healthy adults.METHODS: We performed UPLC/MS-based global lipidomic platform analysis of serum samples (n = 26) in a substudy of a randomised, double-blind, placebo-controlled 3-wk clinical intervention trial investigating the immunomodulatory effects of probiotics in healthy adults.RESULTS: A total of 407 lipids were identified, corresponding to 13 different lipid classes. Serum samples showed decreases in the levels of lysophosphatidylcholines (LysoGPCho), sphingomyelins (SM) and several glycerophosphatidylcholines (GPCho), while triacylglycerols (TAG) were mainly increased in the probiotic LGG group during the intervention. Among the inflammatory variables, IL-6 was moderately associated by changes in global lipidomic profiles, with the top-ranked lipid associated with IL-6 being the proinflammatory LysoGPCho (20:4). There was a weak association between the lipidomic profiles and the two other inflammatory markers, TNF-α and CRP.CONCLUSION: This was the first study to investigate the effects of probiotic intervention on global lipidomic profiles in humans. There are indications that probiotic LGG intervention may lead to changes in serum global lipid profiles, as reflected in decreased GPCho, LysoGPCho and SM as well as mainly increased TAG.

AB - AIM: To investigate the effect of three weeks’ intervention with a probiotic Lactobacillus rhamnosus GG (LGG) bacteria on global serum lipidomic profiles and evaluate whether the changes in inflammatory variables (CRP, TNF-α and IL-6) are reflected in the global lipidomic profiles of healthy adults.METHODS: We performed UPLC/MS-based global lipidomic platform analysis of serum samples (n = 26) in a substudy of a randomised, double-blind, placebo-controlled 3-wk clinical intervention trial investigating the immunomodulatory effects of probiotics in healthy adults.RESULTS: A total of 407 lipids were identified, corresponding to 13 different lipid classes. Serum samples showed decreases in the levels of lysophosphatidylcholines (LysoGPCho), sphingomyelins (SM) and several glycerophosphatidylcholines (GPCho), while triacylglycerols (TAG) were mainly increased in the probiotic LGG group during the intervention. Among the inflammatory variables, IL-6 was moderately associated by changes in global lipidomic profiles, with the top-ranked lipid associated with IL-6 being the proinflammatory LysoGPCho (20:4). There was a weak association between the lipidomic profiles and the two other inflammatory markers, TNF-α and CRP.CONCLUSION: This was the first study to investigate the effects of probiotic intervention on global lipidomic profiles in humans. There are indications that probiotic LGG intervention may lead to changes in serum global lipid profiles, as reflected in decreased GPCho, LysoGPCho and SM as well as mainly increased TAG.

KW - Probiotic

KW - Lactobacillus rhamnosus GG

KW - Lipidomic

KW - Inflammatory mediators

KW - Healthy adults

U2 - 10.3748/wjg.14.3188

DO - 10.3748/wjg.14.3188

M3 - Article

VL - 14

SP - 3188

EP - 3194

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 20

ER -