Effect of size of TiO2 nanoparticles applied onto glass slide and porcine skin on generation of free radicals under ultraviolet irradiation

Alexey P. Popov, Stefan Haag, Martina Meinke, Jürgen Lademann, Alexander V. Priezzhev, Risto Myllylä

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)

Abstract

Titanium dioxide (TiO2) nanoparticles are extensively used today in sunscreens and coatings as protective compounds for human skin and material surfaces from UV radiation. In this paper, such particles are investigated by electron paramagnetic resonance spectroscopy as sources of free radicals under UV irradiation. The surface density of a placebo with embedded particles corresponds to the recommendations of dermatologists (2 mg cm-2). It is revealed that if applied onto glass, small particles 25 nm in diameter produce an increased amount of free radicals compared to the larger ones of 400 nm diam and the placebo itself. However, if applied onto porcine skin in vitro, there is no statistically distinct difference in the amount of radicals generated by the two kinds of particles on skin and by the skin itself. This proves that although particles as part of sunscreens produce free radicals, the effect is negligible in comparison to the production of radicals by skin in vitro.

Original languageEnglish
Article number021011
JournalJournal of Biomedical Optics
Volume14
Issue number2
DOIs
Publication statusPublished - 19 Mar 2009
MoE publication typeA1 Journal article-refereed

Keywords

  • Free radicals
  • Nanoparticles
  • Phototoxicity
  • Porcine skin
  • Titanium dioxide
  • Ultraviolet light

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