Effect of spectral width on short laser pulses propagation through upper layers of human skin: Monte Carlo simulations

Alexey P. Popov, Alexander V. Priezzhev, Risto Myllylä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

Ultrashort laser pulses are widely used now for biomedical diagnostics in order to reveal various tissue abnormities, such as tumors. In particular, the use of these pulses is preferable to investigate relatively thin objects (e.g., layers of human skin). In this case, femtosecond rather than longer pulses should be used due to more pronounced broadening of their temporal profiles for forward detected radiation. However ultrashort pulses are characterized by continuous spectra covering a range of wavelengths. As the optical properties of the probed medium depend on the wavelength, this may cause problems in deconvoluting the signal. In this paper, an attempt is made to investigate this problem. A two-layer model of the object mimicking the upper layers of skin (epidermis and dermis) are considered. Laser pulses of 3.9 to 62.5-fs duration are simulated to impinge onto a plane two-layered medium. The layers differ by optical parameters. The laser beam radius is 0.1 mm. Central wavelengths of spectra of the incident pulses lie in UV, blue, or red spectral regions. Absorption and scattering coefficients of the medium correspond to the real skin; the thicknesses of the successive layers are 0.1 and 0.2 mm respectively. It is shown that the δ-function spectrum approximation may be applied to laser pulses, which central wavelengths lie within the red spectrum region for all tested pulse durations. If the central wavelengths lie within the blue or UV regions, the spectrum width should be taken into account for pulses shorter than 60 fs.

Original languageEnglish
Title of host publicationLaser Interaction with Tissue and Cells XV
EditorsSteven L. Jacques, William P. Roach
PublisherInternational Society for Optics and Photonics SPIE
Pages224-230
DOIs
Publication statusPublished - 27 Oct 2004
MoE publication typeA4 Article in a conference publication
EventBiomedical Optics 2004 - San Jose, United States
Duration: 24 Jan 200429 Jan 2004

Publication series

SeriesProceedings of SPIE
Volume5319
ISSN0277-786X

Conference

ConferenceBiomedical Optics 2004
CountryUnited States
CitySan Jose
Period24/01/0429/01/04

Keywords

  • Absorption
  • Human skin
  • Monte Carlo method
  • Scattering
  • Spectral width
  • Ultrashort laser pulse

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    Popov, A. P., Priezzhev, A. V., & Myllylä, R. (2004). Effect of spectral width on short laser pulses propagation through upper layers of human skin: Monte Carlo simulations. In S. L. Jacques, & W. P. Roach (Eds.), Laser Interaction with Tissue and Cells XV (pp. 224-230). International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 5319 https://doi.org/10.1117/12.529897