Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome: A randomized study (SYSDIET)

M. Uusitupa (Corresponding Author), K. Hermansen, M.J. Savolainen, U. Schwab, M. Kolehmainen, L. Brader, L.S. Mortensen, L. Cloetens, A. Johansson-Persson, G. Önning, M. Landin-Olsson, K.-H. Herzig, J. Hukkanen, F. Rosqvist, D. Iggman, J. Paananen, K.J. Pulkki, M. Siloaho, L. Dragsted, T. BarriK. Overvad, K.E. Bach Knudsen, M.S. Hedemann, P. Arner, I. Dahlman, G.I.A. Borge, P. Baardseth, S.M. Ulven, I. Gunnarsdottir, S. Jónsdóttir, I. Thorsdottir, M. Oresic, Kaisa Poutanen, U. Risérus, B. Åkesson

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Background: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods: We conducted a randomized dietary study lasting for 18–24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m−2, 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4‐week run‐in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole‐grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low‐fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4‐day food diaries and fatty acid composition of serum phospholipids. Results:Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non‐HDL cholesterol (−0.18, mmol L−1 95% CI −0.35; −0.01, P = 0.04), LDL to HDL cholesterol (−0.15, −0.28; −0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (−0.04, −0.07; −0.00, P = 0.025) favouring the Healthy diet. IL‐1 Ra increased during the Control diet (difference −84, −133; −37 ng L−1, P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, −0.23, −0.41; −0.05, P = 0.012) were associated with IL‐1 Ra. Conclusions: Healthy Nordic diet improved lipid profile and had a beneficial effect on low‐grade inflammation.
Original languageEnglish
Pages (from-to)52-66
Number of pages14
JournalJournal of Internal Medicine
Volume274
Issue number1
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

Insulin Resistance
Inflammation
Lipids
Diet
Fruit
Blood Pressure
Diet Records
Plant Oils
Dairy Products
Apolipoprotein A-I
Apolipoproteins B
Magnesium
HDL Cholesterol
Compliance
Meals
Phospholipids
Fishes
Fatty Acids
Fats
Cholesterol

Keywords

  • cardiovascular risk
  • inflammation
  • intervention
  • metabolic syndrome
  • Nordic diet

Cite this

Uusitupa, M. ; Hermansen, K. ; Savolainen, M.J. ; Schwab, U. ; Kolehmainen, M. ; Brader, L. ; Mortensen, L.S. ; Cloetens, L. ; Johansson-Persson, A. ; Önning, G. ; Landin-Olsson, M. ; Herzig, K.-H. ; Hukkanen, J. ; Rosqvist, F. ; Iggman, D. ; Paananen, J. ; Pulkki, K.J. ; Siloaho, M. ; Dragsted, L. ; Barri, T. ; Overvad, K. ; Bach Knudsen, K.E. ; Hedemann, M.S. ; Arner, P. ; Dahlman, I. ; Borge, G.I.A. ; Baardseth, P. ; Ulven, S.M. ; Gunnarsdottir, I. ; Jónsdóttir, S. ; Thorsdottir, I. ; Oresic, M. ; Poutanen, Kaisa ; Risérus, U. ; Åkesson, B. / Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome : A randomized study (SYSDIET). In: Journal of Internal Medicine. 2013 ; Vol. 274, No. 1. pp. 52-66.
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title = "Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome: A randomized study (SYSDIET)",
abstract = "Background: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods: We conducted a randomized dietary study lasting for 18–24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m−2, 67{\%} women). Altogether 309 individuals were screened, 200 started the intervention after 4‐week run‐in period, and 96 (proportion of dropouts 7.9{\%}) and 70 individuals (dropouts 27{\%}) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole‐grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low‐fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4‐day food diaries and fatty acid composition of serum phospholipids. Results:Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non‐HDL cholesterol (−0.18, mmol L−1 95{\%} CI −0.35; −0.01, P = 0.04), LDL to HDL cholesterol (−0.15, −0.28; −0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (−0.04, −0.07; −0.00, P = 0.025) favouring the Healthy diet. IL‐1 Ra increased during the Control diet (difference −84, −133; −37 ng L−1, P = 0.00053). Intakes of saturated fats (E{\%}, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, −0.23, −0.41; −0.05, P = 0.012) were associated with IL‐1 Ra. Conclusions: Healthy Nordic diet improved lipid profile and had a beneficial effect on low‐grade inflammation.",
keywords = "cardiovascular risk, inflammation, intervention, metabolic syndrome, Nordic diet",
author = "M. Uusitupa and K. Hermansen and M.J. Savolainen and U. Schwab and M. Kolehmainen and L. Brader and L.S. Mortensen and L. Cloetens and A. Johansson-Persson and G. {\"O}nning and M. Landin-Olsson and K.-H. Herzig and J. Hukkanen and F. Rosqvist and D. Iggman and J. Paananen and K.J. Pulkki and M. Siloaho and L. Dragsted and T. Barri and K. Overvad and {Bach Knudsen}, K.E. and M.S. Hedemann and P. Arner and I. Dahlman and G.I.A. Borge and P. Baardseth and S.M. Ulven and I. Gunnarsdottir and S. J{\'o}nsd{\'o}ttir and I. Thorsdottir and M. Oresic and Kaisa Poutanen and U. Ris{\'e}rus and B. {\AA}kesson",
year = "2013",
doi = "10.1111/joim.12044",
language = "English",
volume = "274",
pages = "52--66",
journal = "Journal of Internal Medicine",
issn = "0954-6820",
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Uusitupa, M, Hermansen, K, Savolainen, MJ, Schwab, U, Kolehmainen, M, Brader, L, Mortensen, LS, Cloetens, L, Johansson-Persson, A, Önning, G, Landin-Olsson, M, Herzig, K-H, Hukkanen, J, Rosqvist, F, Iggman, D, Paananen, J, Pulkki, KJ, Siloaho, M, Dragsted, L, Barri, T, Overvad, K, Bach Knudsen, KE, Hedemann, MS, Arner, P, Dahlman, I, Borge, GIA, Baardseth, P, Ulven, SM, Gunnarsdottir, I, Jónsdóttir, S, Thorsdottir, I, Oresic, M, Poutanen, K, Risérus, U & Åkesson, B 2013, 'Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome: A randomized study (SYSDIET)', Journal of Internal Medicine, vol. 274, no. 1, pp. 52-66. https://doi.org/10.1111/joim.12044

Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome : A randomized study (SYSDIET). / Uusitupa, M. (Corresponding Author); Hermansen, K.; Savolainen, M.J.; Schwab, U.; Kolehmainen, M.; Brader, L.; Mortensen, L.S.; Cloetens, L.; Johansson-Persson, A.; Önning, G.; Landin-Olsson, M.; Herzig, K.-H.; Hukkanen, J.; Rosqvist, F.; Iggman, D.; Paananen, J.; Pulkki, K.J.; Siloaho, M.; Dragsted, L.; Barri, T.; Overvad, K.; Bach Knudsen, K.E.; Hedemann, M.S.; Arner, P.; Dahlman, I.; Borge, G.I.A.; Baardseth, P.; Ulven, S.M.; Gunnarsdottir, I.; Jónsdóttir, S.; Thorsdottir, I.; Oresic, M.; Poutanen, Kaisa; Risérus, U.; Åkesson, B.

In: Journal of Internal Medicine, Vol. 274, No. 1, 2013, p. 52-66.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome

T2 - A randomized study (SYSDIET)

AU - Uusitupa, M.

AU - Hermansen, K.

AU - Savolainen, M.J.

AU - Schwab, U.

AU - Kolehmainen, M.

AU - Brader, L.

AU - Mortensen, L.S.

AU - Cloetens, L.

AU - Johansson-Persson, A.

AU - Önning, G.

AU - Landin-Olsson, M.

AU - Herzig, K.-H.

AU - Hukkanen, J.

AU - Rosqvist, F.

AU - Iggman, D.

AU - Paananen, J.

AU - Pulkki, K.J.

AU - Siloaho, M.

AU - Dragsted, L.

AU - Barri, T.

AU - Overvad, K.

AU - Bach Knudsen, K.E.

AU - Hedemann, M.S.

AU - Arner, P.

AU - Dahlman, I.

AU - Borge, G.I.A.

AU - Baardseth, P.

AU - Ulven, S.M.

AU - Gunnarsdottir, I.

AU - Jónsdóttir, S.

AU - Thorsdottir, I.

AU - Oresic, M.

AU - Poutanen, Kaisa

AU - Risérus, U.

AU - Åkesson, B.

PY - 2013

Y1 - 2013

N2 - Background: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods: We conducted a randomized dietary study lasting for 18–24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m−2, 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4‐week run‐in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole‐grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low‐fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4‐day food diaries and fatty acid composition of serum phospholipids. Results:Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non‐HDL cholesterol (−0.18, mmol L−1 95% CI −0.35; −0.01, P = 0.04), LDL to HDL cholesterol (−0.15, −0.28; −0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (−0.04, −0.07; −0.00, P = 0.025) favouring the Healthy diet. IL‐1 Ra increased during the Control diet (difference −84, −133; −37 ng L−1, P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, −0.23, −0.41; −0.05, P = 0.012) were associated with IL‐1 Ra. Conclusions: Healthy Nordic diet improved lipid profile and had a beneficial effect on low‐grade inflammation.

AB - Background: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods: We conducted a randomized dietary study lasting for 18–24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m−2, 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4‐week run‐in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole‐grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low‐fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4‐day food diaries and fatty acid composition of serum phospholipids. Results:Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non‐HDL cholesterol (−0.18, mmol L−1 95% CI −0.35; −0.01, P = 0.04), LDL to HDL cholesterol (−0.15, −0.28; −0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (−0.04, −0.07; −0.00, P = 0.025) favouring the Healthy diet. IL‐1 Ra increased during the Control diet (difference −84, −133; −37 ng L−1, P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, −0.23, −0.41; −0.05, P = 0.012) were associated with IL‐1 Ra. Conclusions: Healthy Nordic diet improved lipid profile and had a beneficial effect on low‐grade inflammation.

KW - cardiovascular risk

KW - inflammation

KW - intervention

KW - metabolic syndrome

KW - Nordic diet

U2 - 10.1111/joim.12044

DO - 10.1111/joim.12044

M3 - Article

VL - 274

SP - 52

EP - 66

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

SN - 0954-6820

IS - 1

ER -