a randomized controlled trial. A control group, with twelve subjects, ate no berries. Most measured variables did not differ between the two study groups. However, minor positive alterations were observed in systolic blood pressure, LDL cholesterol, 8-isoprostane, TRAP and resistin. Statistical modelling of lipid
profiles pinpointed a group of 20 lipids for sample separation, indicating that they may be responsible for known positive health effects of berries. Berry supplementation caused changes to microbiota in 35% of the subjects. All these changes were related to either Families of Ruminococcaceae or Lachnospiraceae,
which are the main butyrate-producing bacteria in the human colon. A majority of the subjects in the berry group were identified as urolithin producers.
Conclusions: Ellagitannin rich berry supplementation may have positive effects on serum lipid profiles and on gut microbiota, which might modify bioavailability of the berry ellagitannins. Future studies in humans are warranted.
|Publication status||Published - 2015|
|MoE publication type||A1 Journal article-refereed|
- clinical trial
- microbiological profiling