Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic syndrome

Riitta Puupponen-Pimiä, Tuulikki Seppänen-Laakso, Johanna Maukonen, Liisa Nohynek, Francisco A. Tómas-Barberán, Riitta Törrönen, Marjukka Kolehmainen, Matti Kankainen, Juan C. Espín, Anna-Marja Aura, Kaisa Poutanen, Tiina Leppänen, Eeva Moilanen, Kirsi-Marja Oksman-Caldentey

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Scope: Ellagitannins are polyphenols abundant in strawberries, raspberries and cloudberries. The effects of a mixture of these berries were studied in subjects with features of metabolic syndrome. The study focused on cardiovascular risk factors, gut microbiota and ellagitannin metabolites. Methods and Results: Twenty subjects consumed 300 g of ellagitannin rich berries daily for 8 weeks in
a randomized controlled trial. A control group, with twelve subjects, ate no berries. Most measured variables did not differ between the two study groups. However, minor positive alterations were observed in systolic blood pressure, LDL cholesterol, 8-isoprostane, TRAP and resistin. Statistical modelling of lipid
profiles pinpointed a group of 20 lipids for sample separation, indicating that they may be responsible for known positive health effects of berries. Berry supplementation caused changes to microbiota in 35% of the subjects. All these changes were related to either Families of Ruminococcaceae or Lachnospiraceae,
which are the main butyrate-producing bacteria in the human colon. A majority of the subjects in the berry group were identified as urolithin producers.
Conclusions: Ellagitannin rich berry supplementation may have positive effects on serum lipid profiles and on gut microbiota, which might modify bioavailability of the berry ellagitannins. Future studies in humans are warranted.
Original languageEnglish
Pages (from-to)55-76
JournalDosis
Volume33
Issue number3
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

Fingerprint

Fruit
Lipids
Hydrolyzable Tannins
8-epi-prostaglandin F2alpha
Blood Pressure
Resistin
Fragaria
ellagitannin
Gastrointestinal Microbiome
Butyrates
Microbiota
Polyphenols
LDL Cholesterol
Biological Availability
Colon
Randomized Controlled Trials
Bacteria
Control Groups
Health
Serum

Keywords

  • berries
  • clinical trial
  • ellagitannins
  • lipidomics
  • microbiological profiling

Cite this

Puupponen-Pimiä, Riitta ; Seppänen-Laakso, Tuulikki ; Maukonen, Johanna ; Nohynek, Liisa ; Tómas-Barberán, Francisco A. ; Törrönen, Riitta ; Kolehmainen, Marjukka ; Kankainen, Matti ; Espín, Juan C. ; Aura, Anna-Marja ; Poutanen, Kaisa ; Leppänen, Tiina ; Moilanen, Eeva ; Oksman-Caldentey, Kirsi-Marja. / Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic syndrome. In: Dosis. 2015 ; Vol. 33, No. 3. pp. 55-76.
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abstract = "Scope: Ellagitannins are polyphenols abundant in strawberries, raspberries and cloudberries. The effects of a mixture of these berries were studied in subjects with features of metabolic syndrome. The study focused on cardiovascular risk factors, gut microbiota and ellagitannin metabolites. Methods and Results: Twenty subjects consumed 300 g of ellagitannin rich berries daily for 8 weeks ina randomized controlled trial. A control group, with twelve subjects, ate no berries. Most measured variables did not differ between the two study groups. However, minor positive alterations were observed in systolic blood pressure, LDL cholesterol, 8-isoprostane, TRAP and resistin. Statistical modelling of lipidprofiles pinpointed a group of 20 lipids for sample separation, indicating that they may be responsible for known positive health effects of berries. Berry supplementation caused changes to microbiota in 35{\%} of the subjects. All these changes were related to either Families of Ruminococcaceae or Lachnospiraceae,which are the main butyrate-producing bacteria in the human colon. A majority of the subjects in the berry group were identified as urolithin producers.Conclusions: Ellagitannin rich berry supplementation may have positive effects on serum lipid profiles and on gut microbiota, which might modify bioavailability of the berry ellagitannins. Future studies in humans are warranted.",
keywords = "berries, clinical trial, ellagitannins, lipidomics, microbiological profiling",
author = "Riitta Puupponen-Pimi{\"a} and Tuulikki Sepp{\"a}nen-Laakso and Johanna Maukonen and Liisa Nohynek and T{\'o}mas-Barber{\'a}n, {Francisco A.} and Riitta T{\"o}rr{\"o}nen and Marjukka Kolehmainen and Matti Kankainen and Esp{\'i}n, {Juan C.} and Anna-Marja Aura and Kaisa Poutanen and Tiina Lepp{\"a}nen and Eeva Moilanen and Kirsi-Marja Oksman-Caldentey",
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pages = "55--76",
journal = "Dosis",
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Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic syndrome. / Puupponen-Pimiä, Riitta; Seppänen-Laakso, Tuulikki; Maukonen, Johanna; Nohynek, Liisa; Tómas-Barberán, Francisco A.; Törrönen, Riitta; Kolehmainen, Marjukka; Kankainen, Matti; Espín, Juan C.; Aura, Anna-Marja; Poutanen, Kaisa; Leppänen, Tiina; Moilanen, Eeva; Oksman-Caldentey, Kirsi-Marja.

In: Dosis, Vol. 33, No. 3, 2015, p. 55-76.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Effects of ellagitannin rich berries on blood lipid profiles, gut microbiota and metabolism of phenolic compounds in metabolic syndrome

AU - Puupponen-Pimiä, Riitta

AU - Seppänen-Laakso, Tuulikki

AU - Maukonen, Johanna

AU - Nohynek, Liisa

AU - Tómas-Barberán, Francisco A.

AU - Törrönen, Riitta

AU - Kolehmainen, Marjukka

AU - Kankainen, Matti

AU - Espín, Juan C.

AU - Aura, Anna-Marja

AU - Poutanen, Kaisa

AU - Leppänen, Tiina

AU - Moilanen, Eeva

AU - Oksman-Caldentey, Kirsi-Marja

PY - 2015

Y1 - 2015

N2 - Scope: Ellagitannins are polyphenols abundant in strawberries, raspberries and cloudberries. The effects of a mixture of these berries were studied in subjects with features of metabolic syndrome. The study focused on cardiovascular risk factors, gut microbiota and ellagitannin metabolites. Methods and Results: Twenty subjects consumed 300 g of ellagitannin rich berries daily for 8 weeks ina randomized controlled trial. A control group, with twelve subjects, ate no berries. Most measured variables did not differ between the two study groups. However, minor positive alterations were observed in systolic blood pressure, LDL cholesterol, 8-isoprostane, TRAP and resistin. Statistical modelling of lipidprofiles pinpointed a group of 20 lipids for sample separation, indicating that they may be responsible for known positive health effects of berries. Berry supplementation caused changes to microbiota in 35% of the subjects. All these changes were related to either Families of Ruminococcaceae or Lachnospiraceae,which are the main butyrate-producing bacteria in the human colon. A majority of the subjects in the berry group were identified as urolithin producers.Conclusions: Ellagitannin rich berry supplementation may have positive effects on serum lipid profiles and on gut microbiota, which might modify bioavailability of the berry ellagitannins. Future studies in humans are warranted.

AB - Scope: Ellagitannins are polyphenols abundant in strawberries, raspberries and cloudberries. The effects of a mixture of these berries were studied in subjects with features of metabolic syndrome. The study focused on cardiovascular risk factors, gut microbiota and ellagitannin metabolites. Methods and Results: Twenty subjects consumed 300 g of ellagitannin rich berries daily for 8 weeks ina randomized controlled trial. A control group, with twelve subjects, ate no berries. Most measured variables did not differ between the two study groups. However, minor positive alterations were observed in systolic blood pressure, LDL cholesterol, 8-isoprostane, TRAP and resistin. Statistical modelling of lipidprofiles pinpointed a group of 20 lipids for sample separation, indicating that they may be responsible for known positive health effects of berries. Berry supplementation caused changes to microbiota in 35% of the subjects. All these changes were related to either Families of Ruminococcaceae or Lachnospiraceae,which are the main butyrate-producing bacteria in the human colon. A majority of the subjects in the berry group were identified as urolithin producers.Conclusions: Ellagitannin rich berry supplementation may have positive effects on serum lipid profiles and on gut microbiota, which might modify bioavailability of the berry ellagitannins. Future studies in humans are warranted.

KW - berries

KW - clinical trial

KW - ellagitannins

KW - lipidomics

KW - microbiological profiling

M3 - Article

VL - 33

SP - 55

EP - 76

JO - Dosis

JF - Dosis

SN - 0783-4233

IS - 3

ER -