Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Riitta Puupponen-Pimiä (Corresponding Author), Tuulikki Seppänen-Laakso, M. Kankainen, Johanna Maukonen, R. Törrönen, M. Kolehmainen, T. Leppänen, E. Moilanen, Liisa Nohynek, Anna-Maija Aura, Kaisa Poutanen, F.A. Tómas-Barberán, J.C. Espín, Kirsi-Marja Oksman-Caldentey

Research output: Contribution to journalArticleScientificpeer-review

39 Citations (Scopus)

Abstract

Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.
Original languageEnglish
Pages (from-to)2258-2263
Number of pages5
JournalMolecular Nutrition and Food Research
Volume57
Issue number12
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

Hydrolyzable Tannins
metabolic syndrome
intestinal microorganisms
blood lipids
signs and symptoms (animals and humans)
small fruits
Fruit
Rubus chamaemorus
Lipids
Fragaria
raspberries
Polyphenols
Biological Availability
strawberries
bioavailability
polyphenols
Randomized Controlled Trials
metabolites
Serum
ellagitannin

Keywords

  • Clinical trial
  • Ellagitannin-rich berries
  • Lipidomics
  • Microbiological profiling
  • Urolithins

Cite this

Puupponen-Pimiä, Riitta ; Seppänen-Laakso, Tuulikki ; Kankainen, M. ; Maukonen, Johanna ; Törrönen, R. ; Kolehmainen, M. ; Leppänen, T. ; Moilanen, E. ; Nohynek, Liisa ; Aura, Anna-Maija ; Poutanen, Kaisa ; Tómas-Barberán, F.A. ; Espín, J.C. ; Oksman-Caldentey, Kirsi-Marja. / Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. In: Molecular Nutrition and Food Research. 2013 ; Vol. 57, No. 12. pp. 2258-2263.
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abstract = "Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.",
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Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. / Puupponen-Pimiä, Riitta (Corresponding Author); Seppänen-Laakso, Tuulikki; Kankainen, M.; Maukonen, Johanna; Törrönen, R.; Kolehmainen, M.; Leppänen, T.; Moilanen, E.; Nohynek, Liisa; Aura, Anna-Maija; Poutanen, Kaisa; Tómas-Barberán, F.A.; Espín, J.C.; Oksman-Caldentey, Kirsi-Marja.

In: Molecular Nutrition and Food Research, Vol. 57, No. 12, 2013, p. 2258-2263.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

AU - Puupponen-Pimiä, Riitta

AU - Seppänen-Laakso, Tuulikki

AU - Kankainen, M.

AU - Maukonen, Johanna

AU - Törrönen, R.

AU - Kolehmainen, M.

AU - Leppänen, T.

AU - Moilanen, E.

AU - Nohynek, Liisa

AU - Aura, Anna-Maija

AU - Poutanen, Kaisa

AU - Tómas-Barberán, F.A.

AU - Espín, J.C.

AU - Oksman-Caldentey, Kirsi-Marja

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AB - Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

KW - Clinical trial

KW - Ellagitannin-rich berries

KW - Lipidomics

KW - Microbiological profiling

KW - Urolithins

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M3 - Article

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JO - Molecular Nutrition and Food Research

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