Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Riitta Puupponen-Pimiä; Tuulikki Seppänen-Laakso; M. Kankainen; Johanna Maukonen; R. Törrönen; M. Kolehmainen; T. Leppänen; E. Moilanen; Liisa Nohynek; Anna-Maija Aura; Kaisa Poutanen; F.A. Tómas-Barberán; J.C. Espín; Kirsi-Marja Oksman-Caldentey

doi:10.1002/mnfr.201300280

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Riitta Puupponen-Pimiä (Corresponding Author), Tuulikki Seppänen-Laakso, M. Kankainen, Johanna Maukonen, R. Törrönen, M. Kolehmainen, T. Leppänen, E. Moilanen, Liisa Nohynek, Anna-Maija Aura, Kaisa Poutanen, F.A. Tómas-Barberán, J.C. Espín, Kirsi-Marja Oksman-Caldentey

Research output: Contribution to journal › Article › Scientific › peer-review

57 Citations (Scopus)

Abstract

Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

Original language	English
Pages (from-to)	2258-2263
Number of pages	5
Journal	Molecular Nutrition and Food Research
Volume	57
Issue number	12
DOIs	https://doi.org/10.1002/mnfr.201300280
Publication status	Published - 2013
MoE publication type	A1 Journal article-refereed

Keywords

Clinical trial
Ellagitannin-rich berries
Lipidomics
Microbiological profiling
Urolithins

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Puupponen-Pimiä, R., Seppänen-Laakso, T., Kankainen, M., Maukonen, J., Törrönen, R., Kolehmainen, M., Leppänen, T., Moilanen, E., Nohynek, L., Aura, A-M., Poutanen, K., Tómas-Barberán, F. A., Espín, J. C., & Oksman-Caldentey, K-M. (2013). Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Molecular Nutrition and Food Research, 57(12), 2258-2263. https://doi.org/10.1002/mnfr.201300280

Puupponen-Pimiä, Riitta ; Seppänen-Laakso, Tuulikki ; Kankainen, M. ; Maukonen, Johanna ; Törrönen, R. ; Kolehmainen, M. ; Leppänen, T. ; Moilanen, E. ; Nohynek, Liisa ; Aura, Anna-Maija ; Poutanen, Kaisa ; Tómas-Barberán, F.A. ; Espín, J.C. ; Oksman-Caldentey, Kirsi-Marja. / Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. In: Molecular Nutrition and Food Research. 2013 ; Vol. 57, No. 12. pp. 2258-2263.

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title = "Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome",

abstract = "Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.",

keywords = "Clinical trial, Ellagitannin-rich berries, Lipidomics, Microbiological profiling, Urolithins",

author = "Riitta Puupponen-Pimi{\"a} and Tuulikki Sepp{\"a}nen-Laakso and M. Kankainen and Johanna Maukonen and R. T{\"o}rr{\"o}nen and M. Kolehmainen and T. Lepp{\"a}nen and E. Moilanen and Liisa Nohynek and Anna-Maija Aura and Kaisa Poutanen and F.A. T{\'o}mas-Barber{\'a}n and J.C. Esp{\'i}n and Kirsi-Marja Oksman-Caldentey",

year = "2013",

doi = "10.1002/mnfr.201300280",

language = "English",

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pages = "2258--2263",

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Puupponen-Pimiä, R , Seppänen-Laakso, T, Kankainen, M, Maukonen, J, Törrönen, R, Kolehmainen, M, Leppänen, T, Moilanen, E, Nohynek, L, Aura, A-M, Poutanen, K, Tómas-Barberán, FA, Espín, JC & Oksman-Caldentey, K-M 2013, 'Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome', Molecular Nutrition and Food Research, vol. 57, no. 12, pp. 2258-2263. https://doi.org/10.1002/mnfr.201300280

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. / Puupponen-Pimiä, Riitta (Corresponding Author); Seppänen-Laakso, Tuulikki; Kankainen, M.; Maukonen, Johanna; Törrönen, R.; Kolehmainen, M.; Leppänen, T.; Moilanen, E.; Nohynek, Liisa; Aura, Anna-Maija; Poutanen, Kaisa; Tómas-Barberán, F.A.; Espín, J.C.; Oksman-Caldentey, Kirsi-Marja.

In: Molecular Nutrition and Food Research, Vol. 57, No. 12, 2013, p. 2258-2263.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

AU - Puupponen-Pimiä, Riitta

AU - Seppänen-Laakso, Tuulikki

AU - Kankainen, M.

AU - Maukonen, Johanna

AU - Törrönen, R.

AU - Kolehmainen, M.

AU - Leppänen, T.

AU - Moilanen, E.

AU - Nohynek, Liisa

AU - Aura, Anna-Maija

AU - Poutanen, Kaisa

AU - Tómas-Barberán, F.A.

AU - Espín, J.C.

AU - Oksman-Caldentey, Kirsi-Marja

PY - 2013

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N2 - Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

AB - Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

KW - Clinical trial

KW - Ellagitannin-rich berries

KW - Lipidomics

KW - Microbiological profiling

KW - Urolithins

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DO - 10.1002/mnfr.201300280

M3 - Article

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JO - Molecular Nutrition and Food Research

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