Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Riitta Puupponen-Pimiä; Tuulikki Seppänen-Laakso; Matti Kankainen; Johanna Maukonen; Riitta Törrönen; Marjukka Kolehmainen; Tiina Leppänen; Eeva Moilanen; Liisa Nohynek; Anna-Maija Aura; Kaisa Poutanen; Francisco A. Tómas-Barberán; Juan C. Espín; Kirsi-Marja Oksman-Caldentey

doi:10.1002/mnfr.201300280

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Riitta Puupponen-Pimiä^*
, Tuulikki Seppänen-Laakso
, Matti Kankainen
, Johanna Maukonen
, Riitta Törrönen
, Marjukka Kolehmainen
, Tiina Leppänen
, Eeva Moilanen
, Liisa Nohynek
, Anna-Maija Aura
, Kaisa Poutanen
, Francisco A. Tómas-Barberán
, Juan C. Espín
, Kirsi-Marja Oksman-Caldentey

^*Corresponding author for this work

CSC - IT Center for Science
VTT (former employee or external)
University of Eastern Finland
Tampere University
Tampere University Hospital (TAYS)
Centro de Edafología y Biología Aplicada del Segura (CEBAS)

Research output: Contribution to journal › Article › Scientific › peer-review

106 Citations (Scopus)

Abstract

Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

Original language	English
Pages (from-to)	2258-2263
Journal	Molecular Nutrition and Food Research
Volume	57
Issue number	12
DOIs	https://doi.org/10.1002/mnfr.201300280
Publication status	Published - 2013
MoE publication type	A1 Journal article-refereed

Keywords

Clinical trial
Ellagitannin-rich berries
Lipidomics
Microbiological profiling
Urolithins

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10.1002/mnfr.201300280

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Puupponen-Pimiä, R., Seppänen-Laakso, T., Kankainen, M., Maukonen, J., Törrönen, R., Kolehmainen, M., Leppänen, T., Moilanen, E., Nohynek, L., Aura, A.-M., Poutanen, K., Tómas-Barberán, F. A., Espín, J. C., & Oksman-Caldentey, K.-M. (2013). Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Molecular Nutrition and Food Research, 57(12), 2258-2263. https://doi.org/10.1002/mnfr.201300280

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title = "Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome",

abstract = "Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.",

keywords = "Clinical trial, Ellagitannin-rich berries, Lipidomics, Microbiological profiling, Urolithins",

author = "Riitta Puupponen-Pimi{\"a} and Tuulikki Sepp{\"a}nen-Laakso and Matti Kankainen and Johanna Maukonen and Riitta T{\"o}rr{\"o}nen and Marjukka Kolehmainen and Tiina Lepp{\"a}nen and Eeva Moilanen and Liisa Nohynek and Anna-Maija Aura and Kaisa Poutanen and T{\'o}mas-Barber{\'a}n, \{Francisco A.\} and Esp{\'i}n, \{Juan C.\} and Kirsi-Marja Oksman-Caldentey",

year = "2013",

doi = "10.1002/mnfr.201300280",

language = "English",

volume = "57",

pages = "2258--2263",

journal = "Molecular Nutrition and Food Research",

issn = "1613-4125",

publisher = "Wiley",

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}

Puupponen-Pimiä, R, Seppänen-Laakso, T, Kankainen, M, Maukonen, J, Törrönen, R, Kolehmainen, M, Leppänen, T, Moilanen, E, Nohynek, L, Aura, A-M, Poutanen, K, Tómas-Barberán, FA, Espín, JC & Oksman-Caldentey, K-M 2013, 'Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome', Molecular Nutrition and Food Research, vol. 57, no. 12, pp. 2258-2263. https://doi.org/10.1002/mnfr.201300280

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. / Puupponen-Pimiä, Riitta; Seppänen-Laakso, Tuulikki; Kankainen, Matti et al.
In: Molecular Nutrition and Food Research, Vol. 57, No. 12, 2013, p. 2258-2263.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

AU - Puupponen-Pimiä, Riitta

AU - Seppänen-Laakso, Tuulikki

AU - Kankainen, Matti

AU - Maukonen, Johanna

AU - Törrönen, Riitta

AU - Kolehmainen, Marjukka

AU - Leppänen, Tiina

AU - Moilanen, Eeva

AU - Nohynek, Liisa

AU - Aura, Anna-Maija

AU - Poutanen, Kaisa

AU - Tómas-Barberán, Francisco A.

AU - Espín, Juan C.

AU - Oksman-Caldentey, Kirsi-Marja

PY - 2013

Y1 - 2013

N2 - Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

AB - Ellagitannins are polyphenols abundant in strawberries, raspberries, and cloudberries. The effects of a mixture of these berries were studied in a randomized controlled trial with subjects having symptoms of metabolic syndrome. The study focused on serum lipid profiles, gut microbiota, and ellagitannin metabolites. The results indicate that bioavailability of ellagitannins appears to be dependent on the composition of gut microbiota.

KW - Clinical trial

KW - Ellagitannin-rich berries

KW - Lipidomics

KW - Microbiological profiling

KW - Urolithins

U2 - 10.1002/mnfr.201300280

DO - 10.1002/mnfr.201300280

M3 - Article

SN - 1613-4125

VL - 57

SP - 2258

EP - 2263

JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

IS - 12

ER -

Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome

Abstract

Keywords

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