Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration

Yrjö Mälkki, Riitta Törrönen, Kai Pelkonen, Olavi Myllymäki, Osmo Hänninen, K Syrjänen

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Abstract

Oat bran concentrated with respect to both soluble and insoluble dietary fibre was fed to adult rats, and its effects on serum cholesterol and liver fat infiltration were studied. The feeds contained 15, 30 or 45 g β-glucan/kg, except in control groups where the fibre of the feed was cellulose. Half the experimental groups received the feeds with an addition of 10 g cholesterol and 2 g cholic acid/kg in order to create an hypercholesterolaemic condition. In normocholesterolaemic rats the concentrated oat bran did not cause any significant changes in serum cholesterol concentrations, but reduced liver weight compared with control group rats fed on the cellulose-containing diet. In hypercholesterolaemic rats the concentrated oat bran reduced serum total cholesterol and increased high-density-lipoprotein cholesterol concentration. The effect was seen already at the 15 g/kg concentration of β-glucan, the higher doses tested did not significantly improve the effect. Infiltration of fat into liver cells, especially in the periportal areas, was observed only in hypercholesterolaemic animals. The fat infiltration was accentuated in proportion to the amount of oat-bran concentrate fed.

Original languageEnglish
Pages (from-to)767 - 776
Number of pages10
JournalBritish Journal of Nutrition
Volume70
Issue number3
DOIs
Publication statusPublished - 1993
MoE publication typeA1 Journal article-refereed

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Fats
Cholesterol
Lipids
Glucans
Liver
Serum
Cellulose
Cholic Acid
Control Groups
Dietary Fiber
HDL Cholesterol
Diet
Weights and Measures
Avena

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Mälkki, Y., Törrönen, R., Pelkonen, K., Myllymäki, O., Hänninen, O., & Syrjänen, K. (1993). Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration. British Journal of Nutrition, 70(3), 767 - 776. https://doi.org/10.1079/BJN19930172
Mälkki, Yrjö ; Törrönen, Riitta ; Pelkonen, Kai ; Myllymäki, Olavi ; Hänninen, Osmo ; Syrjänen, K. / Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration. In: British Journal of Nutrition. 1993 ; Vol. 70, No. 3. pp. 767 - 776.
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Mälkki, Y, Törrönen, R, Pelkonen, K, Myllymäki, O, Hänninen, O & Syrjänen, K 1993, 'Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration', British Journal of Nutrition, vol. 70, no. 3, pp. 767 - 776. https://doi.org/10.1079/BJN19930172

Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration. / Mälkki, Yrjö; Törrönen, Riitta; Pelkonen, Kai; Myllymäki, Olavi; Hänninen, Osmo; Syrjänen, K.

In: British Journal of Nutrition, Vol. 70, No. 3, 1993, p. 767 - 776.

Research output: Contribution to journalArticleScientificpeer-review

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T1 - Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration

AU - Mälkki, Yrjö

AU - Törrönen, Riitta

AU - Pelkonen, Kai

AU - Myllymäki, Olavi

AU - Hänninen, Osmo

AU - Syrjänen, K

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AB - Oat bran concentrated with respect to both soluble and insoluble dietary fibre was fed to adult rats, and its effects on serum cholesterol and liver fat infiltration were studied. The feeds contained 15, 30 or 45 g β-glucan/kg, except in control groups where the fibre of the feed was cellulose. Half the experimental groups received the feeds with an addition of 10 g cholesterol and 2 g cholic acid/kg in order to create an hypercholesterolaemic condition. In normocholesterolaemic rats the concentrated oat bran did not cause any significant changes in serum cholesterol concentrations, but reduced liver weight compared with control group rats fed on the cellulose-containing diet. In hypercholesterolaemic rats the concentrated oat bran reduced serum total cholesterol and increased high-density-lipoprotein cholesterol concentration. The effect was seen already at the 15 g/kg concentration of β-glucan, the higher doses tested did not significantly improve the effect. Infiltration of fat into liver cells, especially in the periportal areas, was observed only in hypercholesterolaemic animals. The fat infiltration was accentuated in proportion to the amount of oat-bran concentrate fed.

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Mälkki Y, Törrönen R, Pelkonen K, Myllymäki O, Hänninen O, Syrjänen K. Effects of oat-bran concentrate on rat serum lipids and liver fat infiltration. British Journal of Nutrition. 1993;70(3):767 - 776. https://doi.org/10.1079/BJN19930172