Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors: A randomised controlled two-centre

Rosalba Giacco (Corresponding Author), Jenni Lappi, Giuseppina Costabile, Marjukka Kolehmainen, Ursula Schwab, Rikard Landberg, Matti Uusitupa, Kaisa Poutanen, Giovanni Pacini, Angela A. Rivellese, Gabriele Riccardi, Hannu Mykkänen

    Research output: Contribution to journalArticleScientificpeer-review

    60 Citations (Scopus)


    BACKGROUND & AIMS: Intervention studies investigating the effects of wholegrain intake on glucose and insulin metabolism have provided conflicting results. Aim of this study was the evaluation of glucose and insulin metabolism in response to long-term consumption of rye and whole wheat compared with a diet containing the same amount of refined cereal foods, in individuals with metabolic syndrome from two European locations (Kuopio-Finland/Naples-Italy).
    METHODS: 146 individuals of both genders, age range 40-65 years with metabolic syndrome, were recruited to this study with parallel groups. After a 2-4 week run-in period, participants were assigned to a diet based on wholegrain (wholegrain group) or on refined cereal products (control group), each one for a duration of 12 weeks. Peripheral insulin sensitivity, assessed by FSIGT, lipids and inflammatory markers were measured before and at the end of intervention.
    RESULTS: 61 participants in the control group and 62 in the wholegrain group completed the dietary intervention. Compliance to the two diets was good. At the end of the intervention, insulin sensitivity indices and secretion (SI, QUICKI, DI, dAIRG) and lipids and inflammatory markers did not change significantly in the wholegrain and control groups as compared with baseline and no differences between the two groups were observed.
    CONCLUSIONS: Wholegrain cereal foods consumption compared with refined cereals for 12 weeks did not affect peripheral insulin sensitivity.
    Original languageEnglish
    Pages (from-to)941-949
    JournalClinical Nutrition
    Issue number6
    Publication statusPublished - Dec 2013
    MoE publication typeA1 Journal article-refereed


    • cereal fibre
    • clucose metabolism
    • inflammatory markers
    • insulin sensitivity
    • metabolic syndrome
    • wholegrain


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