Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors: A randomised controlled two-centre

R. Giacco (Corresponding Author), J. Lappi, G. Costabile, M. Kolehmainen, U. Schwab, R. Landberg, M. Uusitupa, Kaisa Poutanen, G. Pacini, A.A. Rivellese, G. Riccardi, H. Mykkänen

Research output: Contribution to journalArticleScientificpeer-review

38 Citations (Scopus)

Abstract

BACKGROUND & AIMS: Intervention studies investigating the effects of wholegrain intake on glucose and insulin metabolism have provided conflicting results. Aim of this study was the evaluation of glucose and insulin metabolism in response to long-term consumption of rye and whole wheat compared with a diet containing the same amount of refined cereal foods, in individuals with metabolic syndrome from two European locations (Kuopio-Finland/Naples-Italy). METHODS: 146 individuals of both genders, age range 40-65 years with metabolic syndrome, were recruited to this study with parallel groups. After a 2-4 week run-in period, participants were assigned to a diet based on wholegrain (wholegrain group) or on refined cereal products (control group), each one for a duration of 12 weeks. Peripheral insulin sensitivity, assessed by FSIGT, lipids and inflammatory markers were measured before and at the end of intervention. RESULTS: 61 participants in the control group and 62 in the wholegrain group completed the dietary intervention. Compliance to the two diets was good. At the end of the intervention, insulin sensitivity indices and secretion (SI, QUICKI, DI, dAIRG) and lipids and inflammatory markers did not change significantly in the wholegrain and control groups as compared with baseline and no differences between the two groups were observed. CONCLUSIONS: Wholegrain cereal foods consumption compared with refined cereals for 12 weeks did not affect peripheral insulin sensitivity.
Original languageEnglish
Pages (from-to)941-949
Number of pages8
JournalClinical Nutrition
Volume32
Issue number6
DOIs
Publication statusPublished - 2013
MoE publication typeA1 Journal article-refereed

Fingerprint

Triticum
Insulin Resistance
Food
Diet
Control Groups
Insulin
Lipids
Glucose
Finland
Italy
Secale
Edible Grain

Keywords

  • cereal fibre
  • clucose metabolism
  • inflammatory markers
  • insulin sensitivity
  • metabolic syndrome
  • wholegrain

Cite this

Giacco, R., Lappi, J., Costabile, G., Kolehmainen, M., Schwab, U., Landberg, R., ... Mykkänen, H. (2013). Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors: A randomised controlled two-centre. Clinical Nutrition, 32(6), 941-949. https://doi.org/10.1016/j.clnu.2013.01.016
Giacco, R. ; Lappi, J. ; Costabile, G. ; Kolehmainen, M. ; Schwab, U. ; Landberg, R. ; Uusitupa, M. ; Poutanen, Kaisa ; Pacini, G. ; Rivellese, A.A. ; Riccardi, G. ; Mykkänen, H. / Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors : A randomised controlled two-centre. In: Clinical Nutrition. 2013 ; Vol. 32, No. 6. pp. 941-949.
@article{19d96c0b6c644c6fb11b88d9a139c416,
title = "Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors: A randomised controlled two-centre",
abstract = "BACKGROUND & AIMS: Intervention studies investigating the effects of wholegrain intake on glucose and insulin metabolism have provided conflicting results. Aim of this study was the evaluation of glucose and insulin metabolism in response to long-term consumption of rye and whole wheat compared with a diet containing the same amount of refined cereal foods, in individuals with metabolic syndrome from two European locations (Kuopio-Finland/Naples-Italy). METHODS: 146 individuals of both genders, age range 40-65 years with metabolic syndrome, were recruited to this study with parallel groups. After a 2-4 week run-in period, participants were assigned to a diet based on wholegrain (wholegrain group) or on refined cereal products (control group), each one for a duration of 12 weeks. Peripheral insulin sensitivity, assessed by FSIGT, lipids and inflammatory markers were measured before and at the end of intervention. RESULTS: 61 participants in the control group and 62 in the wholegrain group completed the dietary intervention. Compliance to the two diets was good. At the end of the intervention, insulin sensitivity indices and secretion (SI, QUICKI, DI, dAIRG) and lipids and inflammatory markers did not change significantly in the wholegrain and control groups as compared with baseline and no differences between the two groups were observed. CONCLUSIONS: Wholegrain cereal foods consumption compared with refined cereals for 12 weeks did not affect peripheral insulin sensitivity.",
keywords = "cereal fibre, clucose metabolism, inflammatory markers, insulin sensitivity, metabolic syndrome, wholegrain",
author = "R. Giacco and J. Lappi and G. Costabile and M. Kolehmainen and U. Schwab and R. Landberg and M. Uusitupa and Kaisa Poutanen and G. Pacini and A.A. Rivellese and G. Riccardi and H. Mykk{\"a}nen",
year = "2013",
doi = "10.1016/j.clnu.2013.01.016",
language = "English",
volume = "32",
pages = "941--949",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",
number = "6",

}

Giacco, R, Lappi, J, Costabile, G, Kolehmainen, M, Schwab, U, Landberg, R, Uusitupa, M, Poutanen, K, Pacini, G, Rivellese, AA, Riccardi, G & Mykkänen, H 2013, 'Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors: A randomised controlled two-centre', Clinical Nutrition, vol. 32, no. 6, pp. 941-949. https://doi.org/10.1016/j.clnu.2013.01.016

Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors : A randomised controlled two-centre. / Giacco, R. (Corresponding Author); Lappi, J.; Costabile, G.; Kolehmainen, M.; Schwab, U.; Landberg, R.; Uusitupa, M.; Poutanen, Kaisa; Pacini, G.; Rivellese, A.A.; Riccardi, G.; Mykkänen, H.

In: Clinical Nutrition, Vol. 32, No. 6, 2013, p. 941-949.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors

T2 - A randomised controlled two-centre

AU - Giacco, R.

AU - Lappi, J.

AU - Costabile, G.

AU - Kolehmainen, M.

AU - Schwab, U.

AU - Landberg, R.

AU - Uusitupa, M.

AU - Poutanen, Kaisa

AU - Pacini, G.

AU - Rivellese, A.A.

AU - Riccardi, G.

AU - Mykkänen, H.

PY - 2013

Y1 - 2013

N2 - BACKGROUND & AIMS: Intervention studies investigating the effects of wholegrain intake on glucose and insulin metabolism have provided conflicting results. Aim of this study was the evaluation of glucose and insulin metabolism in response to long-term consumption of rye and whole wheat compared with a diet containing the same amount of refined cereal foods, in individuals with metabolic syndrome from two European locations (Kuopio-Finland/Naples-Italy). METHODS: 146 individuals of both genders, age range 40-65 years with metabolic syndrome, were recruited to this study with parallel groups. After a 2-4 week run-in period, participants were assigned to a diet based on wholegrain (wholegrain group) or on refined cereal products (control group), each one for a duration of 12 weeks. Peripheral insulin sensitivity, assessed by FSIGT, lipids and inflammatory markers were measured before and at the end of intervention. RESULTS: 61 participants in the control group and 62 in the wholegrain group completed the dietary intervention. Compliance to the two diets was good. At the end of the intervention, insulin sensitivity indices and secretion (SI, QUICKI, DI, dAIRG) and lipids and inflammatory markers did not change significantly in the wholegrain and control groups as compared with baseline and no differences between the two groups were observed. CONCLUSIONS: Wholegrain cereal foods consumption compared with refined cereals for 12 weeks did not affect peripheral insulin sensitivity.

AB - BACKGROUND & AIMS: Intervention studies investigating the effects of wholegrain intake on glucose and insulin metabolism have provided conflicting results. Aim of this study was the evaluation of glucose and insulin metabolism in response to long-term consumption of rye and whole wheat compared with a diet containing the same amount of refined cereal foods, in individuals with metabolic syndrome from two European locations (Kuopio-Finland/Naples-Italy). METHODS: 146 individuals of both genders, age range 40-65 years with metabolic syndrome, were recruited to this study with parallel groups. After a 2-4 week run-in period, participants were assigned to a diet based on wholegrain (wholegrain group) or on refined cereal products (control group), each one for a duration of 12 weeks. Peripheral insulin sensitivity, assessed by FSIGT, lipids and inflammatory markers were measured before and at the end of intervention. RESULTS: 61 participants in the control group and 62 in the wholegrain group completed the dietary intervention. Compliance to the two diets was good. At the end of the intervention, insulin sensitivity indices and secretion (SI, QUICKI, DI, dAIRG) and lipids and inflammatory markers did not change significantly in the wholegrain and control groups as compared with baseline and no differences between the two groups were observed. CONCLUSIONS: Wholegrain cereal foods consumption compared with refined cereals for 12 weeks did not affect peripheral insulin sensitivity.

KW - cereal fibre

KW - clucose metabolism

KW - inflammatory markers

KW - insulin sensitivity

KW - metabolic syndrome

KW - wholegrain

U2 - 10.1016/j.clnu.2013.01.016

DO - 10.1016/j.clnu.2013.01.016

M3 - Article

VL - 32

SP - 941

EP - 949

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 6

ER -