TY - JOUR
T1 - Effects of short- and long-term Mediterranean-based dietary treatment on plasma LC-QTOF/MS metabolic profiling of subjects with metabolic syndrome features
T2 - The Metabolic Syndrome Reduction in Navarra (RESMENA) randomized controlled trial
AU - Bondia-Pons, Isabel
AU - Martinez, José Alfredo
AU - de la Iglesia, Rocia
AU - Lopez-Legarrea, Patricia
AU - Poutanen, Kaisa
AU - Hanhineva, Kati
AU - Zulet, Maria de los Ángeles
PY - 2015
Y1 - 2015
N2 - Scope: Adherence to the Mediterranean diet has been
associated with a reduced risk of metabolic syndrome
(MetS). Metabolomics approach may contribute to identify
beneficial associations of metabolic changes affected by
Mediterranean diet-based interventions with inflammatory
and oxidative-stress markers related to the etiology and
development of the MetS. Methods and results: Liquid
chromatography coupled to quadrupole-time of flight-MS
metabolic profiling was applied to plasma from a 6-month
randomized intervention with two sequential periods, a
2-month nutritional-learning intervention period, and a
4-month self-control period, with two energy-restricted
diets; the RESMENA diet (based on the Mediterranean
dietary pattern) and the Control diet (based on the
American Heart Association guidelines), in 72 subjects
with a high BMI and at least two features of MetS. The
major contributing biomarkers of each sequential period
were lipids, mainly phospholipids and lysophospholipids.
Dependency network analysis showed a different pattern of
associations between metabolic changes and clinical
variables after 2 and 6 month of intervention, with a
highly interconnected network during the
nutritional-learning intervention period of the study.
Conclusion: The 2-month RESMENA diet produced significant
changes in the plasma metabolic profile of subjects with
MetS features. However, at the end of the 6-month study,
most of the associations between metabolic and clinical
variables disappeared; suggesting that adherence to
healthy dietary habits had declined during the
self-control period.
AB - Scope: Adherence to the Mediterranean diet has been
associated with a reduced risk of metabolic syndrome
(MetS). Metabolomics approach may contribute to identify
beneficial associations of metabolic changes affected by
Mediterranean diet-based interventions with inflammatory
and oxidative-stress markers related to the etiology and
development of the MetS. Methods and results: Liquid
chromatography coupled to quadrupole-time of flight-MS
metabolic profiling was applied to plasma from a 6-month
randomized intervention with two sequential periods, a
2-month nutritional-learning intervention period, and a
4-month self-control period, with two energy-restricted
diets; the RESMENA diet (based on the Mediterranean
dietary pattern) and the Control diet (based on the
American Heart Association guidelines), in 72 subjects
with a high BMI and at least two features of MetS. The
major contributing biomarkers of each sequential period
were lipids, mainly phospholipids and lysophospholipids.
Dependency network analysis showed a different pattern of
associations between metabolic changes and clinical
variables after 2 and 6 month of intervention, with a
highly interconnected network during the
nutritional-learning intervention period of the study.
Conclusion: The 2-month RESMENA diet produced significant
changes in the plasma metabolic profile of subjects with
MetS features. However, at the end of the 6-month study,
most of the associations between metabolic and clinical
variables disappeared; suggesting that adherence to
healthy dietary habits had declined during the
self-control period.
KW - dependency networks
KW - LC-QTOF/MS
KW - mediterranean diet
KW - metabolomics
KW - metabolic syndrome
U2 - 10.1002/mnfr.201400309
DO - 10.1002/mnfr.201400309
M3 - Article
SN - 1613-4125
VL - 59
SP - 711
EP - 728
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 4
ER -