Abstract
Scope: Adherence to the Mediterranean diet has been
associated with a reduced risk of metabolic syndrome
(MetS). Metabolomics approach may contribute to identify
beneficial associations of metabolic changes affected by
Mediterranean diet-based interventions with inflammatory
and oxidative-stress markers related to the etiology and
development of the MetS. Methods and results: Liquid
chromatography coupled to quadrupole-time of flight-MS
metabolic profiling was applied to plasma from a 6-month
randomized intervention with two sequential periods, a
2-month nutritional-learning intervention period, and a
4-month self-control period, with two energy-restricted
diets; the RESMENA diet (based on the Mediterranean
dietary pattern) and the Control diet (based on the
American Heart Association guidelines), in 72 subjects
with a high BMI and at least two features of MetS. The
major contributing biomarkers of each sequential period
were lipids, mainly phospholipids and lysophospholipids.
Dependency network analysis showed a different pattern of
associations between metabolic changes and clinical
variables after 2 and 6 month of intervention, with a
highly interconnected network during the
nutritional-learning intervention period of the study.
Conclusion: The 2-month RESMENA diet produced significant
changes in the plasma metabolic profile of subjects with
MetS features. However, at the end of the 6-month study,
most of the associations between metabolic and clinical
variables disappeared; suggesting that adherence to
healthy dietary habits had declined during the
self-control period.
Original language | English |
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Pages (from-to) | 711-728 |
Journal | Molecular Nutrition and Food Research |
Volume | 59 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2015 |
MoE publication type | A1 Journal article-refereed |
Keywords
- dependency networks
- LC-QTOF/MS
- mediterranean diet
- metabolomics
- metabolic syndrome