Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 711-728 |
| Journal | Molecular Nutrition and Food Research |
| Volume | 59 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 |
| MoE publication type | A1 Journal article-refereed |
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Keywords
- dependency networks
- LC-QTOF/MS
- mediterranean diet
- metabolomics
- metabolic syndrome
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Effects of short- and long-term Mediterranean-based dietary treatment on plasma LC-QTOF/MS metabolic profiling of subjects with metabolic syndrome features : The Metabolic Syndrome Reduction in Navarra (RESMENA) randomized controlled trial. / Bondia-Pons, I.; Martinez, J.A.; de la Iglesia, R.; Lopez-Legarrea, P.; Poutanen, K.; Hanhineva, K.; Zulet, M.D.L.A. (Corresponding Author).
In: Molecular Nutrition and Food Research, Vol. 59, No. 4, 2015, p. 711-728.Research output: Contribution to journal › Article › Scientific › peer-review
TY - JOUR
T1 - Effects of short- and long-term Mediterranean-based dietary treatment on plasma LC-QTOF/MS metabolic profiling of subjects with metabolic syndrome features
T2 - The Metabolic Syndrome Reduction in Navarra (RESMENA) randomized controlled trial
AU - Bondia-Pons, I.
AU - Martinez, J.A.
AU - de la Iglesia, R.
AU - Lopez-Legarrea, P.
AU - Poutanen, K.
AU - Hanhineva, K.
AU - Zulet, M.D.L.A.
PY - 2015
Y1 - 2015
N2 - Scope: Adherence to the Mediterranean diet has been associated with a reduced risk of metabolic syndrome (MetS). Metabolomics approach may contribute to identify beneficial associations of metabolic changes affected by Mediterranean diet-based interventions with inflammatory and oxidative-stress markers related to the etiology and development of the MetS. Methods and results: Liquid chromatography coupled to quadrupole-time of flight-MS metabolic profiling was applied to plasma from a 6-month randomized intervention with two sequential periods, a 2-month nutritional-learning intervention period, and a 4-month self-control period, with two energy-restricted diets; the RESMENA diet (based on the Mediterranean dietary pattern) and the Control diet (based on the American Heart Association guidelines), in 72 subjects with a high BMI and at least two features of MetS. The major contributing biomarkers of each sequential period were lipids, mainly phospholipids and lysophospholipids. Dependency network analysis showed a different pattern of associations between metabolic changes and clinical variables after 2 and 6 month of intervention, with a highly interconnected network during the nutritional-learning intervention period of the study. Conclusion: The 2-month RESMENA diet produced significant changes in the plasma metabolic profile of subjects with MetS features. However, at the end of the 6-month study, most of the associations between metabolic and clinical variables disappeared; suggesting that adherence to healthy dietary habits had declined during the self-control period.
AB - Scope: Adherence to the Mediterranean diet has been associated with a reduced risk of metabolic syndrome (MetS). Metabolomics approach may contribute to identify beneficial associations of metabolic changes affected by Mediterranean diet-based interventions with inflammatory and oxidative-stress markers related to the etiology and development of the MetS. Methods and results: Liquid chromatography coupled to quadrupole-time of flight-MS metabolic profiling was applied to plasma from a 6-month randomized intervention with two sequential periods, a 2-month nutritional-learning intervention period, and a 4-month self-control period, with two energy-restricted diets; the RESMENA diet (based on the Mediterranean dietary pattern) and the Control diet (based on the American Heart Association guidelines), in 72 subjects with a high BMI and at least two features of MetS. The major contributing biomarkers of each sequential period were lipids, mainly phospholipids and lysophospholipids. Dependency network analysis showed a different pattern of associations between metabolic changes and clinical variables after 2 and 6 month of intervention, with a highly interconnected network during the nutritional-learning intervention period of the study. Conclusion: The 2-month RESMENA diet produced significant changes in the plasma metabolic profile of subjects with MetS features. However, at the end of the 6-month study, most of the associations between metabolic and clinical variables disappeared; suggesting that adherence to healthy dietary habits had declined during the self-control period.
KW - dependency networks
KW - LC-QTOF/MS
KW - mediterranean diet
KW - metabolomics
KW - metabolic syndrome
U2 - 10.1002/mnfr.201400309
DO - 10.1002/mnfr.201400309
M3 - Article
VL - 59
SP - 711
EP - 728
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
SN - 1613-4125
IS - 4
ER -