Effects of spray drying on physicochemical properties of chitosan acid salts.

Mirna Fernández Cervera, Jyrki Heinämäki (Corresponding Author), Nilia de la Paz, Orestes López, Sirkka Liisa Maunu, Tommi Virtanen, Timo Hatanpää, Osmo Antikainen, Antonio Nogueira, Jorge Fundora, Jouko Yliruusi

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (Panulirus argus) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS (13)C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state (13)C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm(-1) were diminished suggesting that -NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm(-1), respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (P. argus) origin.

Original languageEnglish
Pages (from-to)637-649
Number of pages13
JournalAAPS PharmSciTech
Volume12
Issue number2
DOIs
Publication statusPublished - Jun 2011
MoE publication typeA1 Journal article-refereed

Fingerprint

spray drying
Chitosan
chitosan
physicochemical properties
Salts
salts
Acids
acids
Fourier Analysis
Chitin
spectroscopy
chitin
Panulirus argus
Powder Diffraction
Spectrum Analysis
lobsters
X-Ray Diffraction
nuclear magnetic resonance spectroscopy
powders
X-radiation

Keywords

  • chitin
  • chitosan salt
  • lobster (Panulirus argus)
  • physicochemical properties
  • spray drying

Cite this

Cervera, M. F., Heinämäki, J., de la Paz, N., López, O., Maunu, S. L., Virtanen, T., ... Yliruusi, J. (2011). Effects of spray drying on physicochemical properties of chitosan acid salts. AAPS PharmSciTech, 12(2), 637-649. https://doi.org/10.1208/s12249-011-9620-3
Cervera, Mirna Fernández ; Heinämäki, Jyrki ; de la Paz, Nilia ; López, Orestes ; Maunu, Sirkka Liisa ; Virtanen, Tommi ; Hatanpää, Timo ; Antikainen, Osmo ; Nogueira, Antonio ; Fundora, Jorge ; Yliruusi, Jouko. / Effects of spray drying on physicochemical properties of chitosan acid salts. In: AAPS PharmSciTech. 2011 ; Vol. 12, No. 2. pp. 637-649.
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abstract = "The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (Panulirus argus) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS (13)C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state (13)C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm(-1) were diminished suggesting that -NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm(-1), respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (P. argus) origin.",
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Cervera, MF, Heinämäki, J, de la Paz, N, López, O, Maunu, SL, Virtanen, T, Hatanpää, T, Antikainen, O, Nogueira, A, Fundora, J & Yliruusi, J 2011, 'Effects of spray drying on physicochemical properties of chitosan acid salts.', AAPS PharmSciTech, vol. 12, no. 2, pp. 637-649. https://doi.org/10.1208/s12249-011-9620-3

Effects of spray drying on physicochemical properties of chitosan acid salts. / Cervera, Mirna Fernández; Heinämäki, Jyrki (Corresponding Author); de la Paz, Nilia; López, Orestes; Maunu, Sirkka Liisa; Virtanen, Tommi; Hatanpää, Timo; Antikainen, Osmo; Nogueira, Antonio; Fundora, Jorge; Yliruusi, Jouko.

In: AAPS PharmSciTech, Vol. 12, No. 2, 06.2011, p. 637-649.

Research output: Contribution to journalArticleScientificpeer-review

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AU - Maunu, Sirkka Liisa

AU - Virtanen, Tommi

AU - Hatanpää, Timo

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AU - Yliruusi, Jouko

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