Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activitie: A randomized trial (Sysdimet)

M Lankinen (Corresponding Author), Marjukka Kolehmainen, T Jääskeläinen, J Paananen, L Joukamo, A J Kangas, P Soininen, Kaisa Poutanen, H Mykkänen, H Gylling, M Oresic, M Jauhiainen, M Ala-Korpela, M Uusitupa, U Schwab

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Abstract

Objective: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. Methods: Altogether 131 subjects (40-70 y, BMI 26-39 kg/m ) with impaired glucose metabolism and features of the 2 metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as lowmolecular- weight metabolites. Results: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable. Conclusions: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis
Original languageEnglish
Article numbere90352
JournalPLoS ONE
Volume9
Issue number2
DOIs
Publication statusPublished - 2014
MoE publication typeA1 Journal article-refereed

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Vaccinium myrtillus
bilberries
Metabolome
whole grain foods
Fish
grain products
Fishes
fatty fish
metabolic syndrome
Serum
fish
Lipids
insulin
lipids
metabolites
Metabolites
Fatty Acids
fish consumption
Cereal products
Insulin

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Lankinen, M., Kolehmainen, M., Jääskeläinen, T., Paananen, J., Joukamo, L., Kangas, A. J., ... Schwab, U. (2014). Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activitie: A randomized trial (Sysdimet). PLoS ONE, 9(2), [e90352]. https://doi.org/10.1371/journal.pone.0090352
Lankinen, M ; Kolehmainen, Marjukka ; Jääskeläinen, T ; Paananen, J ; Joukamo, L ; Kangas, A J ; Soininen, P ; Poutanen, Kaisa ; Mykkänen, H ; Gylling, H ; Oresic, M ; Jauhiainen, M ; Ala-Korpela, M ; Uusitupa, M ; Schwab, U. / Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activitie : A randomized trial (Sysdimet). In: PLoS ONE. 2014 ; Vol. 9, No. 2.
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title = "Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activitie: A randomized trial (Sysdimet)",
abstract = "Objective: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. Methods: Altogether 131 subjects (40-70 y, BMI 26-39 kg/m ) with impaired glucose metabolism and features of the 2 metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as lowmolecular- weight metabolites. Results: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable. Conclusions: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis",
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Lankinen, M, Kolehmainen, M, Jääskeläinen, T, Paananen, J, Joukamo, L, Kangas, AJ, Soininen, P, Poutanen, K, Mykkänen, H, Gylling, H, Oresic, M, Jauhiainen, M, Ala-Korpela, M, Uusitupa, M & Schwab, U 2014, 'Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activitie: A randomized trial (Sysdimet)', PLoS ONE, vol. 9, no. 2, e90352. https://doi.org/10.1371/journal.pone.0090352

Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activitie : A randomized trial (Sysdimet). / Lankinen, M (Corresponding Author); Kolehmainen, Marjukka; Jääskeläinen, T; Paananen, J; Joukamo, L; Kangas, A J; Soininen, P; Poutanen, Kaisa; Mykkänen, H; Gylling, H; Oresic, M; Jauhiainen, M; Ala-Korpela, M; Uusitupa, M; Schwab, U.

In: PLoS ONE, Vol. 9, No. 2, e90352, 2014.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activitie

T2 - A randomized trial (Sysdimet)

AU - Lankinen, M

AU - Kolehmainen, Marjukka

AU - Jääskeläinen, T

AU - Paananen, J

AU - Joukamo, L

AU - Kangas, A J

AU - Soininen, P

AU - Poutanen, Kaisa

AU - Mykkänen, H

AU - Gylling, H

AU - Oresic, M

AU - Jauhiainen, M

AU - Ala-Korpela, M

AU - Uusitupa, M

AU - Schwab, U

PY - 2014

Y1 - 2014

N2 - Objective: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. Methods: Altogether 131 subjects (40-70 y, BMI 26-39 kg/m ) with impaired glucose metabolism and features of the 2 metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as lowmolecular- weight metabolites. Results: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable. Conclusions: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis

AB - Objective: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. Methods: Altogether 131 subjects (40-70 y, BMI 26-39 kg/m ) with impaired glucose metabolism and features of the 2 metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as lowmolecular- weight metabolites. Results: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable. Conclusions: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis

U2 - 10.1371/journal.pone.0090352

DO - 10.1371/journal.pone.0090352

M3 - Article

VL - 9

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

M1 - e90352

ER -