Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles

Maija Tapanainen (Corresponding Author), Pasi I. Jalava, Jorma Mäki-Paakkanen, Pasi Hakulinen, Heikki Lamberg, Jarno Ruusunen, Jarkko Tissari, Jorma Jokiniemi, Maija-Riitta Hirvonen

Research output: Contribution to journalArticleScientificpeer-review

22 Citations (Scopus)

Abstract

Context: Particulate matter (PM) has been identified as a major environmental pollutant causing severe health problems. Large amounts of the harmful particulate matter (PM) are emitted from residential wood combustion, but the toxicological properties of wood combustion particles are poorly known. Objective: To investigate chemical and consequent toxicological characteristics of PM1 emitted from different phases of batch combustion in four heating appliances. Materials and methods: Mouse RAW264.7 macrophages and human BEAS-2B bronchial epithelial cells were exposed for 24 h to different doses (15-300 µg/mL) of wood combustion particles. After the exposure, cytotoxicity, genotoxicity, production of the inflammatory mediators (TNF-a and MIP-2) and effects on the cell cycle were assessed. Furthermore, the detected toxicological responses were compared with the chemical composition of PM1 samples including PAHs, metals and ions. Results: All the wood combustion samples exerted high cytotoxicity, but only moderate inflammatory activity. The particles emitted from the inefficient phase of batch combustion in the sauna stove (SS) induced the most extensive cytotoxic and genotoxic responses in mammalian cells. Polycyclic aromatic hydrocarbons (PAHs) and other organic compounds in PM1 samples might have contributed to these effects. Instead, water-soluble metals seemed to participate in the cytotoxic responses triggered by the particles from more efficient batch combustion in the masonry heaters. Overall, the toxicological responses were decreased when the combustion phase was more efficient. Conclusion: Efficiency of batch combustion plays a significant role in the harmfulness of PM even under incomplete wood combustion processes.
Original languageEnglish
Pages (from-to)343-355
JournalInhalation Toxicology
Volume24
Issue number6
DOIs
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Fingerprint

Toxicology
Chemical properties
Wood
Particulate Matter
Polycyclic Aromatic Hydrocarbons
Metals
Steam Bath
Environmental Pollutants
Cytotoxicity
Heating
Cell Cycle
Epithelial Cells
Macrophages
Cells
Ions
Stoves
Water
Health
Medical problems
Organic compounds

Keywords

  • Chemical composition
  • cytotoxicity
  • genotoxicity
  • inflammation
  • particulate matter
  • wood combustion

Cite this

Tapanainen, M., Jalava, P. I., Mäki-Paakkanen, J., Hakulinen, P., Lamberg, H., Ruusunen, J., ... Hirvonen, M-R. (2012). Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles. Inhalation Toxicology, 24(6), 343-355. https://doi.org/10.3109/08958378.2012.671858
Tapanainen, Maija ; Jalava, Pasi I. ; Mäki-Paakkanen, Jorma ; Hakulinen, Pasi ; Lamberg, Heikki ; Ruusunen, Jarno ; Tissari, Jarkko ; Jokiniemi, Jorma ; Hirvonen, Maija-Riitta. / Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles. In: Inhalation Toxicology. 2012 ; Vol. 24, No. 6. pp. 343-355.
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abstract = "Context: Particulate matter (PM) has been identified as a major environmental pollutant causing severe health problems. Large amounts of the harmful particulate matter (PM) are emitted from residential wood combustion, but the toxicological properties of wood combustion particles are poorly known. Objective: To investigate chemical and consequent toxicological characteristics of PM1 emitted from different phases of batch combustion in four heating appliances. Materials and methods: Mouse RAW264.7 macrophages and human BEAS-2B bronchial epithelial cells were exposed for 24 h to different doses (15-300 µg/mL) of wood combustion particles. After the exposure, cytotoxicity, genotoxicity, production of the inflammatory mediators (TNF-a and MIP-2) and effects on the cell cycle were assessed. Furthermore, the detected toxicological responses were compared with the chemical composition of PM1 samples including PAHs, metals and ions. Results: All the wood combustion samples exerted high cytotoxicity, but only moderate inflammatory activity. The particles emitted from the inefficient phase of batch combustion in the sauna stove (SS) induced the most extensive cytotoxic and genotoxic responses in mammalian cells. Polycyclic aromatic hydrocarbons (PAHs) and other organic compounds in PM1 samples might have contributed to these effects. Instead, water-soluble metals seemed to participate in the cytotoxic responses triggered by the particles from more efficient batch combustion in the masonry heaters. Overall, the toxicological responses were decreased when the combustion phase was more efficient. Conclusion: Efficiency of batch combustion plays a significant role in the harmfulness of PM even under incomplete wood combustion processes.",
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author = "Maija Tapanainen and Jalava, {Pasi I.} and Jorma M{\"a}ki-Paakkanen and Pasi Hakulinen and Heikki Lamberg and Jarno Ruusunen and Jarkko Tissari and Jorma Jokiniemi and Maija-Riitta Hirvonen",
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Tapanainen, M, Jalava, PI, Mäki-Paakkanen, J, Hakulinen, P, Lamberg, H, Ruusunen, J, Tissari, J, Jokiniemi, J & Hirvonen, M-R 2012, 'Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles', Inhalation Toxicology, vol. 24, no. 6, pp. 343-355. https://doi.org/10.3109/08958378.2012.671858

Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles. / Tapanainen, Maija (Corresponding Author); Jalava, Pasi I.; Mäki-Paakkanen, Jorma; Hakulinen, Pasi; Lamberg, Heikki; Ruusunen, Jarno; Tissari, Jarkko; Jokiniemi, Jorma; Hirvonen, Maija-Riitta.

In: Inhalation Toxicology, Vol. 24, No. 6, 2012, p. 343-355.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Efficiency of log wood combustion affects the toxicological and chemical properties of emission particles

AU - Tapanainen, Maija

AU - Jalava, Pasi I.

AU - Mäki-Paakkanen, Jorma

AU - Hakulinen, Pasi

AU - Lamberg, Heikki

AU - Ruusunen, Jarno

AU - Tissari, Jarkko

AU - Jokiniemi, Jorma

AU - Hirvonen, Maija-Riitta

PY - 2012

Y1 - 2012

N2 - Context: Particulate matter (PM) has been identified as a major environmental pollutant causing severe health problems. Large amounts of the harmful particulate matter (PM) are emitted from residential wood combustion, but the toxicological properties of wood combustion particles are poorly known. Objective: To investigate chemical and consequent toxicological characteristics of PM1 emitted from different phases of batch combustion in four heating appliances. Materials and methods: Mouse RAW264.7 macrophages and human BEAS-2B bronchial epithelial cells were exposed for 24 h to different doses (15-300 µg/mL) of wood combustion particles. After the exposure, cytotoxicity, genotoxicity, production of the inflammatory mediators (TNF-a and MIP-2) and effects on the cell cycle were assessed. Furthermore, the detected toxicological responses were compared with the chemical composition of PM1 samples including PAHs, metals and ions. Results: All the wood combustion samples exerted high cytotoxicity, but only moderate inflammatory activity. The particles emitted from the inefficient phase of batch combustion in the sauna stove (SS) induced the most extensive cytotoxic and genotoxic responses in mammalian cells. Polycyclic aromatic hydrocarbons (PAHs) and other organic compounds in PM1 samples might have contributed to these effects. Instead, water-soluble metals seemed to participate in the cytotoxic responses triggered by the particles from more efficient batch combustion in the masonry heaters. Overall, the toxicological responses were decreased when the combustion phase was more efficient. Conclusion: Efficiency of batch combustion plays a significant role in the harmfulness of PM even under incomplete wood combustion processes.

AB - Context: Particulate matter (PM) has been identified as a major environmental pollutant causing severe health problems. Large amounts of the harmful particulate matter (PM) are emitted from residential wood combustion, but the toxicological properties of wood combustion particles are poorly known. Objective: To investigate chemical and consequent toxicological characteristics of PM1 emitted from different phases of batch combustion in four heating appliances. Materials and methods: Mouse RAW264.7 macrophages and human BEAS-2B bronchial epithelial cells were exposed for 24 h to different doses (15-300 µg/mL) of wood combustion particles. After the exposure, cytotoxicity, genotoxicity, production of the inflammatory mediators (TNF-a and MIP-2) and effects on the cell cycle were assessed. Furthermore, the detected toxicological responses were compared with the chemical composition of PM1 samples including PAHs, metals and ions. Results: All the wood combustion samples exerted high cytotoxicity, but only moderate inflammatory activity. The particles emitted from the inefficient phase of batch combustion in the sauna stove (SS) induced the most extensive cytotoxic and genotoxic responses in mammalian cells. Polycyclic aromatic hydrocarbons (PAHs) and other organic compounds in PM1 samples might have contributed to these effects. Instead, water-soluble metals seemed to participate in the cytotoxic responses triggered by the particles from more efficient batch combustion in the masonry heaters. Overall, the toxicological responses were decreased when the combustion phase was more efficient. Conclusion: Efficiency of batch combustion plays a significant role in the harmfulness of PM even under incomplete wood combustion processes.

KW - Chemical composition

KW - cytotoxicity

KW - genotoxicity

KW - inflammation

KW - particulate matter

KW - wood combustion

U2 - 10.3109/08958378.2012.671858

DO - 10.3109/08958378.2012.671858

M3 - Article

VL - 24

SP - 343

EP - 355

JO - Inhalation Toxicology

JF - Inhalation Toxicology

SN - 0895-8378

IS - 6

ER -