Abstract
The performance of current biomedical titanium alloys is limited by inflammatory and severe inflammatory conditions after implantation. In this study, a novel Ti–Nb–Zr–Si (TNZS) alloy was developed and compared with commercially pure titanium, and Ti–6Al–4V alloy. Electrochemical parameters of specimens were monitored during 1 h and 12 h immersion in phosphate buffered saline (PBS) as a normal, PBS/hydrogen peroxide (H2O2) as an inflammatory, and PBS/H2O2/albumin/lactate as a severe inflammatory media. The results showed an effect of the H2O2 in inflammatory condition and the synergistic behavior of H2O2, albumin, and lactate in severe inflammatory condition towards decreasing the corrosion resistance of titanium biomaterials. Electrochemical tests revealed a superior corrosion resistance of the TNZS in all conditions due to the presence of silicide phases. The developed TNZS was tested for subsequent cell culture investigation to understand its biocompatibility nature. It exhibited favorable cell-materials interactions in vitro compared with Ti–6Al–4V. The results suggest that TNZS alloy might be a competitive biomaterial for orthopedic applications.
| Original language | English |
|---|---|
| Article number | 2312 |
| Journal | Scientific Reports |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 9 Feb 2023 |
| MoE publication type | A1 Journal article-refereed |
Funding
Financial supports of the European Commission under FP6 SME integrated project \u201CMeddelcoat\u201D (contract 026501-2) and from the European Union\u2019s Horizon 2020 research and innovation program under the Marie Sk\u0142odowska-Curie ITN \u201CPremurosa\u201D (GA 860462) are gratefully acknowledged. Authors are greatly thankful for the late Dr. A. V. Mazur for help in TNZS alloy preparation, Dr. H. Yu for assistance in thermodynamic database optimization and Dr. D. Sukhomlinov for his help in performing the SEM/EDS. The LEMI assistance in analyzing details for the cells-materials interactions, led by Mrs. Prof. M.-F. Harmand and Mrs. D. Pierron, is also gratefully acknowledged.
