Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil

Tuulikki Seppänen-Laakso; I. Laakso; T. Lehtimäki; R. Rontu; E. Moilanen; T. Solakivi; L. Seppo; H. Vanhanen; K. Kiviranta; R. Hiltunen

doi:10.1016/j.plefa.2010.02.001

Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil

Tuulikki Seppänen-Laakso, I. Laakso (Corresponding Author), T. Lehtimäki, R. Rontu, E. Moilanen, T. Solakivi, L. Seppo, H. Vanhanen, K. Kiviranta, R. Hiltunen

Research output: Contribution to journal › Article › Scientific › peer-review

15 Citations (Scopus)

Abstract

The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16–62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of α-linolenic acid (α-LLA) was doubled. Efficient competitive inhibition by α-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6–3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.

Original language	English
Pages (from-to)	45-54
Number of pages	10
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/j.plefa.2010.02.001
Publication status	Published - 2010
MoE publication type	A1 Journal article-refereed

Keywords

Plasma fatty acids
Competitive interactions
Plasma fibrinogen
Serum lipids
Lipid oxidation
Canola-type rapeseed oil

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Seppänen-Laakso, T., Laakso, I., Lehtimäki, T., Rontu, R., Moilanen, E., Solakivi, T., Seppo, L., Vanhanen, H., Kiviranta, K., & Hiltunen, R. (2010). Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. Prostaglandins Leukotrienes and Essential Fatty Acids, 83(1), 45-54. https://doi.org/10.1016/j.plefa.2010.02.001

Seppänen-Laakso, Tuulikki ; Laakso, I. ; Lehtimäki, T. ; Rontu, R. ; Moilanen, E. ; Solakivi, T. ; Seppo, L. ; Vanhanen, H. ; Kiviranta, K. ; Hiltunen, R. / Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2010 ; Vol. 83, No. 1. pp. 45-54.

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title = "Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil",

abstract = "The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16–62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of α-linolenic acid (α-LLA) was doubled. Efficient competitive inhibition by α-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6–3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.",

keywords = "Plasma fatty acids, Competitive interactions, Plasma fibrinogen, Serum lipids, Lipid oxidation, Canola-type rapeseed oil",

author = "Tuulikki Sepp{\"a}nen-Laakso and I. Laakso and T. Lehtim{\"a}ki and R. Rontu and E. Moilanen and T. Solakivi and L. Seppo and H. Vanhanen and K. Kiviranta and R. Hiltunen",

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doi = "10.1016/j.plefa.2010.02.001",

language = "English",

volume = "83",

pages = "45--54",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

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Seppänen-Laakso, T, Laakso, I, Lehtimäki, T, Rontu, R, Moilanen, E, Solakivi, T, Seppo, L, Vanhanen, H, Kiviranta, K & Hiltunen, R 2010, 'Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 83, no. 1, pp. 45-54. https://doi.org/10.1016/j.plefa.2010.02.001

Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil. / Seppänen-Laakso, Tuulikki; Laakso, I. (Corresponding Author); Lehtimäki, T.; Rontu, R.; Moilanen, E.; Solakivi, T.; Seppo, L.; Vanhanen, H.; Kiviranta, K.; Hiltunen, R.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 83, No. 1, 2010, p. 45-54.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Elevated plasma fibrinogen caused by inadequate α-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil

AU - Seppänen-Laakso, Tuulikki

AU - Laakso, I.

AU - Lehtimäki, T.

AU - Rontu, R.

AU - Moilanen, E.

AU - Solakivi, T.

AU - Seppo, L.

AU - Vanhanen, H.

AU - Kiviranta, K.

AU - Hiltunen, R.

PY - 2010

Y1 - 2010

N2 - The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16–62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of α-linolenic acid (α-LLA) was doubled. Efficient competitive inhibition by α-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6–3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.

AB - The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16–62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of α-linolenic acid (α-LLA) was doubled. Efficient competitive inhibition by α-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6–3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.

KW - Plasma fatty acids

KW - Competitive interactions

KW - Plasma fibrinogen

KW - Serum lipids

KW - Lipid oxidation

KW - Canola-type rapeseed oil

U2 - 10.1016/j.plefa.2010.02.001

DO - 10.1016/j.plefa.2010.02.001

M3 - Article

VL - 83

SP - 45

EP - 54

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

SN - 0952-3278

IS - 1

ER -