Abstract
The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16–62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of α-linolenic acid (α-LLA) was doubled. Efficient competitive inhibition by α-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6–3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.
Original language | English |
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Pages (from-to) | 45-54 |
Number of pages | 10 |
Journal | Prostaglandins Leukotrienes and Essential Fatty Acids |
Volume | 83 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2010 |
MoE publication type | A1 Journal article-refereed |
Keywords
- Plasma fatty acids
- Competitive interactions
- Plasma fibrinogen
- Serum lipids
- Lipid oxidation
- Canola-type rapeseed oil