Elevated pro-inflammatory and lipotoxic mucosal lipids characterize irritable bowel syndrome

Kajsa Kajander, Eveliina Myllyluoma, Sinikka Kyrönpalo, Martin Rasmussen, Pentti Sipponen, Ismo Mattila, Tuulikki Seppänen-Laakso, Heikki Vapaatalo, Matej Oresic, Riitta Korpela (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

31 Citations (Scopus)


AIM: To investigate the pathophysiology of irritable bowel syndrome (IBS) by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.

METHODS: Fifteen IBS patients fulfilling the Rome II criteria, and nine healthy volunteers were included in the study. A combined lipidomics (UPLC/MS) and metabolomics (GC × GC-TOF) approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.

RESULTS: Overall, lipid levels were elevated in patients with IBS. The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines. Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides, glycosphingolipids, and di- and triacylglycerols. Among the metabolites, the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects (P = 0.03).

CONCLUSION: IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile. Especially, there was an increase in several lipid species such as lysophospholipids and ceramides.
Original languageEnglish
Pages (from-to)6068-6074
Number of pages7
JournalWorld Journal of Gastroenterology
Issue number48
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed


  • Functional gastrointestinal diseases
  • irritable bowel syndrome
  • histopathology

Fingerprint Dive into the research topics of 'Elevated pro-inflammatory and lipotoxic mucosal lipids characterize irritable bowel syndrome'. Together they form a unique fingerprint.

  • Cite this

    Kajander, K., Myllyluoma, E., Kyrönpalo, S., Rasmussen, M., Sipponen, P., Mattila, I., Seppänen-Laakso, T., Vapaatalo, H., Oresic, M., & Korpela, R. (2009). Elevated pro-inflammatory and lipotoxic mucosal lipids characterize irritable bowel syndrome. World Journal of Gastroenterology, 15(48), 6068-6074. https://doi.org/10.3748/wjg.15.6068