Abstract
The enantioselective esterification of racemic ibuprofen with n-propanol by immobilized Mucor miehel lipase in supercritical carbon dioxide was studied. The enantiomeric excess of the product (eep) was 70 % at 15...20 % conversion. The enantioselectivity was faintly affected by temperature and the concentration of ibuprofen and lipase. The optimum temperature was 45 °C. The initial reaction rate increased with pressure, but enantioselectivity was not affected by pressure changes. The reaction rates in supercritical carbon dioxide at optimized conditions and in n-hexane were similar.
Original language | English |
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Pages (from-to) | 825-830 |
Journal | Biotechnology Letters |
Volume | 16 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1994 |
MoE publication type | A1 Journal article-refereed |