Enantioselective esterification of ibuprofen in supercritical carbon dioxide by immobilized lipase

Markku Rantakylä, Olli Aaltonen

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The enantioselective esterification of racemic ibuprofen with n-propanol by immobilized Mucor miehel lipase in supercritical carbon dioxide was studied. The enantiomeric excess of the product (eep) was 70 % at 15...20 % conversion. The enantioselectivity was faintly affected by temperature and the concentration of ibuprofen and lipase. The optimum temperature was 45 °C. The initial reaction rate increased with pressure, but enantioselectivity was not affected by pressure changes. The reaction rates in supercritical carbon dioxide at optimized conditions and in n-hexane were similar.
Original languageEnglish
Pages (from-to)825-830
Number of pages6
JournalBiotechnology Letters
Issue number8
Publication statusPublished - 1994
MoE publication typeA1 Journal article-refereed


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