Engineering Cells and Proteins – creating pharmaceuticals

Marinus Gerardus Casteleijn, Dominique Richardson

Research output: Contribution to journalArticleScientific

Abstract

Pharmaceutical biotechnology is big business; it currently consists of 1/6 of the total volume of the pharmaceutical market and continues to grow steadily. Expression of therapeutic proteins is mainly done in living cells, although ‘cell free protein synthesis’ (CFPS) or ‘in-vitro transcription translation’ (IVTT) is beginning to emerge as an alternative for commercial production. In this article we will highlight some of the more recent advances in protein expression systems for the production of pharmaceutical proteins. We will also discuss current trends in the engineering of pharmaceutical proteins with improved properties.
Original languageEnglish
JournalEuropean Pharmaceutical Review
Volume2014
Issue number4
Publication statusPublished - 5 Sep 2014
MoE publication typeB1 Article in a scientific magazine

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