Abstract
The blood boron concentration regulates directly the BNCT irradiation
time in which the prescribed dose to the patient is delivered. Therefore
a proper estimation of the blood boron concentration for the treatment
field based on the measured blood samples before irradiation is
required. The bi-exponential model fit using Levenberg—Marquardt method
was implemented for this purpose to provide the blood boron
concentration estimates directly to the treatment data flow during the
BNCT procedure. The harmonic mean bi-exponential decay half-lives of the
studied patient data (n=28) were 15±8 and 320±70 min for the faster and slower half-life. The model uncertainty (n=28) was reasonably low, 0.7±0.1 μg/g
(about 5%). The implemented algorithm provides a robust method for
temporal blood boron concentration estimation for BPA-F mediated BNCT.
Utilization of the infusion data improves the reliability of the
estimate. The overall data flow during the treatment fulfills the
practical requirements concerning the BNCT procedure.
| Original language | English |
|---|---|
| Pages (from-to) | 823 - 827 |
| Number of pages | 5 |
| Journal | Applied Radiation and Isotopes |
| Volume | 61 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2004 |
| MoE publication type | A1 Journal article-refereed |
Keywords
- boronophenylalanine
- fructose
- BPA-F
- pharmacokinetics
- Levenberg-Marquardt