Enhanced blood boron concentration estimation for BPA-F mediated BNCT

Mika Kortesniemi (Corresponding Author), T. Seppälä, Iiro Auterinen, S. Savolainen

    Research output: Contribution to journalArticleScientificpeer-review

    16 Citations (Scopus)


    The blood boron concentration regulates directly the BNCT irradiation time in which the prescribed dose to the patient is delivered. Therefore a proper estimation of the blood boron concentration for the treatment field based on the measured blood samples before irradiation is required. The bi-exponential model fit using Levenberg—Marquardt method was implemented for this purpose to provide the blood boron concentration estimates directly to the treatment data flow during the BNCT procedure. The harmonic mean bi-exponential decay half-lives of the studied patient data (n=28) were 15±8 and 320±70 min for the faster and slower half-life. The model uncertainty (n=28) was reasonably low, 0.7±0.1 μg/g (about 5%). The implemented algorithm provides a robust method for temporal blood boron concentration estimation for BPA-F mediated BNCT. Utilization of the infusion data improves the reliability of the estimate. The overall data flow during the treatment fulfills the practical requirements concerning the BNCT procedure.
    Original languageEnglish
    Pages (from-to)823 - 827
    Number of pages5
    JournalApplied Radiation and Isotopes
    Issue number5
    Publication statusPublished - 2004
    MoE publication typeA1 Journal article-refereed


    • boronophenylalanine
    • fructose
    • BPA-F
    • pharmacokinetics
    • Levenberg-Marquardt


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