Enhanced blood boron concentration estimation for BPA-F mediated BNCT

Mika Kortesniemi (Corresponding Author), T. Seppälä, Iiro Auterinen, S. Savolainen

Research output: Contribution to journalArticleScientificpeer-review

13 Citations (Scopus)

Abstract

The blood boron concentration regulates directly the BNCT irradiation time in which the prescribed dose to the patient is delivered. Therefore a proper estimation of the blood boron concentration for the treatment field based on the measured blood samples before irradiation is required. The bi-exponential model fit using Levenberg—Marquardt method was implemented for this purpose to provide the blood boron concentration estimates directly to the treatment data flow during the BNCT procedure. The harmonic mean bi-exponential decay half-lives of the studied patient data (n=28) were 15±8 and 320±70 min for the faster and slower half-life. The model uncertainty (n=28) was reasonably low, 0.7±0.1 μg/g (about 5%). The implemented algorithm provides a robust method for temporal blood boron concentration estimation for BPA-F mediated BNCT. Utilization of the infusion data improves the reliability of the estimate. The overall data flow during the treatment fulfills the practical requirements concerning the BNCT procedure.
Original languageEnglish
Pages (from-to)823 - 827
Number of pages5
JournalApplied Radiation and Isotopes
Volume61
Issue number5
DOIs
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed

Fingerprint

blood
boron
half life
irradiation
estimates
harmonics
dosage
requirements
decay

Keywords

  • boronophenylalanine
  • fructose
  • BPA-F
  • pharmacokinetics
  • Levenberg-Marquardt

Cite this

Kortesniemi, Mika ; Seppälä, T. ; Auterinen, Iiro ; Savolainen, S. / Enhanced blood boron concentration estimation for BPA-F mediated BNCT. In: Applied Radiation and Isotopes. 2004 ; Vol. 61, No. 5. pp. 823 - 827.
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abstract = "The blood boron concentration regulates directly the BNCT irradiation time in which the prescribed dose to the patient is delivered. Therefore a proper estimation of the blood boron concentration for the treatment field based on the measured blood samples before irradiation is required. The bi-exponential model fit using Levenberg—Marquardt method was implemented for this purpose to provide the blood boron concentration estimates directly to the treatment data flow during the BNCT procedure. The harmonic mean bi-exponential decay half-lives of the studied patient data (n=28) were 15±8 and 320±70 min for the faster and slower half-life. The model uncertainty (n=28) was reasonably low, 0.7±0.1 μg/g (about 5{\%}). The implemented algorithm provides a robust method for temporal blood boron concentration estimation for BPA-F mediated BNCT. Utilization of the infusion data improves the reliability of the estimate. The overall data flow during the treatment fulfills the practical requirements concerning the BNCT procedure.",
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Enhanced blood boron concentration estimation for BPA-F mediated BNCT. / Kortesniemi, Mika (Corresponding Author); Seppälä, T.; Auterinen, Iiro; Savolainen, S.

In: Applied Radiation and Isotopes, Vol. 61, No. 5, 2004, p. 823 - 827.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Enhanced blood boron concentration estimation for BPA-F mediated BNCT

AU - Kortesniemi, Mika

AU - Seppälä, T.

AU - Auterinen, Iiro

AU - Savolainen, S.

PY - 2004

Y1 - 2004

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AB - The blood boron concentration regulates directly the BNCT irradiation time in which the prescribed dose to the patient is delivered. Therefore a proper estimation of the blood boron concentration for the treatment field based on the measured blood samples before irradiation is required. The bi-exponential model fit using Levenberg—Marquardt method was implemented for this purpose to provide the blood boron concentration estimates directly to the treatment data flow during the BNCT procedure. The harmonic mean bi-exponential decay half-lives of the studied patient data (n=28) were 15±8 and 320±70 min for the faster and slower half-life. The model uncertainty (n=28) was reasonably low, 0.7±0.1 μg/g (about 5%). The implemented algorithm provides a robust method for temporal blood boron concentration estimation for BPA-F mediated BNCT. Utilization of the infusion data improves the reliability of the estimate. The overall data flow during the treatment fulfills the practical requirements concerning the BNCT procedure.

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KW - fructose

KW - BPA-F

KW - pharmacokinetics

KW - Levenberg-Marquardt

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