Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers

Maarit Tarvainen (Corresponding Author), Riitta Sutinen, Soili Peltonen, Hannu Mikkonen, Jaana Maunus, Kalle Vähä-Heikkilä, Vesa-Pekka Lehto, Petteri Paronen

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Purpose: The aim of this study was to investigate the ability of n-alkenyl succinic anhydrides (n-ASAs) to improve the film-forming characteristics of a novel coating polymer, potato starch acetate degree of substitution 2.8 (SA). n-ASAs were also applied to improve the otherwise brittle properties of ethyl cellulose (EC) aqueous dispersion (Aquacoat®) and EC solvent-based films. Methods: The effectiveness of two n-ASAs, 2-octenyl succinic anhydride (OSA) and 2-dodecen-1-ylsuccinic anhydride were evaluated as plasticizers. Mechanical properties, both water vapor and drug permeabilities, and glass transition temperatures of the cast free films were measured. Triethyl citrate and dibutyl sebacate were used as reference plasticizers. Results: The long hydrocarbon chain of n-ASA, with its accessible carbonyl groups, enabled a strong plasticization effect on the tested polymers. Due to the excellent mechanical properties (i.e., a tough film structure with considerable flexibility) and low permeability of the plasticized films, n-ASAs, and especially OSA proved to be an ideal plasticizer particularly for EC based coatings. Also, the EC aqueous dispersion plasticized with n-ASAs resulted in a markedly enhanced coalescence of the colloidal polymer particles, even at low drying temperatures. Conclusions: In applications where a coating with high flexibility is required, n-ASAs can be used as plasticizers at moderately high concentrations (up to 60–70%, w/w) without losing the high tensile strength, excellent toughness and low permeability of EC and SA films.
Original languageEnglish
Pages (from-to)363-371
JournalEuropean Journal of Pharmaceutical Sciences
Volume19
Issue number5
DOIs
Publication statusPublished - 2003
MoE publication typeA1 Journal article-refereed

Fingerprint

Succinic Anhydrides
Plasticizers
Permeability
Polymers
Transition Temperature
Anhydrides
Tensile Strength
Steam
Solanum tuberosum
Hydrocarbons
ethyl cellulose
acetylcellulose
ethyl acetate
starch acetate
Glass

Keywords

  • biopolymers

Cite this

Tarvainen, Maarit ; Sutinen, Riitta ; Peltonen, Soili ; Mikkonen, Hannu ; Maunus, Jaana ; Vähä-Heikkilä, Kalle ; Lehto, Vesa-Pekka ; Paronen, Petteri. / Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers. In: European Journal of Pharmaceutical Sciences. 2003 ; Vol. 19, No. 5. pp. 363-371.
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title = "Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers",
abstract = "Purpose: The aim of this study was to investigate the ability of n-alkenyl succinic anhydrides (n-ASAs) to improve the film-forming characteristics of a novel coating polymer, potato starch acetate degree of substitution 2.8 (SA). n-ASAs were also applied to improve the otherwise brittle properties of ethyl cellulose (EC) aqueous dispersion (Aquacoat{\circledR}) and EC solvent-based films. Methods: The effectiveness of two n-ASAs, 2-octenyl succinic anhydride (OSA) and 2-dodecen-1-ylsuccinic anhydride were evaluated as plasticizers. Mechanical properties, both water vapor and drug permeabilities, and glass transition temperatures of the cast free films were measured. Triethyl citrate and dibutyl sebacate were used as reference plasticizers. Results: The long hydrocarbon chain of n-ASA, with its accessible carbonyl groups, enabled a strong plasticization effect on the tested polymers. Due to the excellent mechanical properties (i.e., a tough film structure with considerable flexibility) and low permeability of the plasticized films, n-ASAs, and especially OSA proved to be an ideal plasticizer particularly for EC based coatings. Also, the EC aqueous dispersion plasticized with n-ASAs resulted in a markedly enhanced coalescence of the colloidal polymer particles, even at low drying temperatures. Conclusions: In applications where a coating with high flexibility is required, n-ASAs can be used as plasticizers at moderately high concentrations (up to 60–70{\%}, w/w) without losing the high tensile strength, excellent toughness and low permeability of EC and SA films.",
keywords = "biopolymers",
author = "Maarit Tarvainen and Riitta Sutinen and Soili Peltonen and Hannu Mikkonen and Jaana Maunus and Kalle V{\"a}h{\"a}-Heikkil{\"a} and Vesa-Pekka Lehto and Petteri Paronen",
year = "2003",
doi = "10.1016/S0928-0987(03)00137-4",
language = "English",
volume = "19",
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journal = "European Journal of Pharmaceutical Sciences",
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Tarvainen, M, Sutinen, R, Peltonen, S, Mikkonen, H, Maunus, J, Vähä-Heikkilä, K, Lehto, V-P & Paronen, P 2003, 'Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers', European Journal of Pharmaceutical Sciences, vol. 19, no. 5, pp. 363-371. https://doi.org/10.1016/S0928-0987(03)00137-4

Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers. / Tarvainen, Maarit (Corresponding Author); Sutinen, Riitta; Peltonen, Soili; Mikkonen, Hannu; Maunus, Jaana; Vähä-Heikkilä, Kalle; Lehto, Vesa-Pekka; Paronen, Petteri.

In: European Journal of Pharmaceutical Sciences, Vol. 19, No. 5, 2003, p. 363-371.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers

AU - Tarvainen, Maarit

AU - Sutinen, Riitta

AU - Peltonen, Soili

AU - Mikkonen, Hannu

AU - Maunus, Jaana

AU - Vähä-Heikkilä, Kalle

AU - Lehto, Vesa-Pekka

AU - Paronen, Petteri

PY - 2003

Y1 - 2003

N2 - Purpose: The aim of this study was to investigate the ability of n-alkenyl succinic anhydrides (n-ASAs) to improve the film-forming characteristics of a novel coating polymer, potato starch acetate degree of substitution 2.8 (SA). n-ASAs were also applied to improve the otherwise brittle properties of ethyl cellulose (EC) aqueous dispersion (Aquacoat®) and EC solvent-based films. Methods: The effectiveness of two n-ASAs, 2-octenyl succinic anhydride (OSA) and 2-dodecen-1-ylsuccinic anhydride were evaluated as plasticizers. Mechanical properties, both water vapor and drug permeabilities, and glass transition temperatures of the cast free films were measured. Triethyl citrate and dibutyl sebacate were used as reference plasticizers. Results: The long hydrocarbon chain of n-ASA, with its accessible carbonyl groups, enabled a strong plasticization effect on the tested polymers. Due to the excellent mechanical properties (i.e., a tough film structure with considerable flexibility) and low permeability of the plasticized films, n-ASAs, and especially OSA proved to be an ideal plasticizer particularly for EC based coatings. Also, the EC aqueous dispersion plasticized with n-ASAs resulted in a markedly enhanced coalescence of the colloidal polymer particles, even at low drying temperatures. Conclusions: In applications where a coating with high flexibility is required, n-ASAs can be used as plasticizers at moderately high concentrations (up to 60–70%, w/w) without losing the high tensile strength, excellent toughness and low permeability of EC and SA films.

AB - Purpose: The aim of this study was to investigate the ability of n-alkenyl succinic anhydrides (n-ASAs) to improve the film-forming characteristics of a novel coating polymer, potato starch acetate degree of substitution 2.8 (SA). n-ASAs were also applied to improve the otherwise brittle properties of ethyl cellulose (EC) aqueous dispersion (Aquacoat®) and EC solvent-based films. Methods: The effectiveness of two n-ASAs, 2-octenyl succinic anhydride (OSA) and 2-dodecen-1-ylsuccinic anhydride were evaluated as plasticizers. Mechanical properties, both water vapor and drug permeabilities, and glass transition temperatures of the cast free films were measured. Triethyl citrate and dibutyl sebacate were used as reference plasticizers. Results: The long hydrocarbon chain of n-ASA, with its accessible carbonyl groups, enabled a strong plasticization effect on the tested polymers. Due to the excellent mechanical properties (i.e., a tough film structure with considerable flexibility) and low permeability of the plasticized films, n-ASAs, and especially OSA proved to be an ideal plasticizer particularly for EC based coatings. Also, the EC aqueous dispersion plasticized with n-ASAs resulted in a markedly enhanced coalescence of the colloidal polymer particles, even at low drying temperatures. Conclusions: In applications where a coating with high flexibility is required, n-ASAs can be used as plasticizers at moderately high concentrations (up to 60–70%, w/w) without losing the high tensile strength, excellent toughness and low permeability of EC and SA films.

KW - biopolymers

U2 - 10.1016/S0928-0987(03)00137-4

DO - 10.1016/S0928-0987(03)00137-4

M3 - Article

VL - 19

SP - 363

EP - 371

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

SN - 0928-0987

IS - 5

ER -