@inproceedings{c4e9154f3a3d494cb5dbf0adc9779d78,
title = "Enhancement of upconversion deep-tissue imaging using optical clearing",
abstract = "We report on the deep-tissue imaging using novel upconversion nanoparticles (UCNPs) β-NaYF4:Yb3+,Tm3+ (excitation wavelength: 975 nm, detection wavelength: 800 nm) and glycerol as an optical clearing agent to enhance imaging from under 6-mm-thick porcine muscle tissue samples. We show that improvement of luminescent label visualization is caused by transforming of the diffuse label-emitted light into the direct component. This results in the increase in visibility (ratio of the sum and difference of the maximal and minimal intensity) of the label and increase in maximal signal intensity thus making the combination of the phosphors and optical clearing promising for precise detection of tissue-embedded labelled inhomogeneities.",
keywords = "biotissue, deep-tissue imaging, luminescence, optical clearing, Upconversion",
author = "Popov, {A. P.} and Khaydukov, {E. V.} and Bykov, {A. V.} and Semchishen, {V. A.} and Tuchin, {V. V.}",
year = "2015",
month = jan,
day = "1",
doi = "10.1117/12.2183860",
language = "English",
isbn = "978-1-6284-1705-0",
series = "Progress in Biomedical Optics and Imaging",
publisher = "International Society for Optics and Photonics SPIE",
number = "58",
editor = "Arjen Amelink and Vitkin, {I. Alex}",
booktitle = "Novel Biophotonics Techniques and Applications III",
address = "United States",
note = "Novel Biophotonics Techniques and Applications III ; Conference date: 24-06-2015 Through 25-06-2015",
}