Enzymatic degradation of and bovine serum albumin release from starch-acetate films

Laura Tuovinen; Soili Peltonen; Tapani Suortti; Nicholas Crowther; Matti Elomaa; Kristiina Järvinen

doi:10.1021/bm015581e

Enzymatic degradation of and bovine serum albumin release from starch-acetate films

Laura Tuovinen (Corresponding Author), Soili Peltonen, Tapani Suortti, Nicholas Crowther, Matti Elomaa, Kristiina Järvinen

VTT Technical Research Centre of Finland

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

Abstract

The effect of acetylation of potato starch on swelling, enzymatic degradation, and bovine serum albumin (BSA, molecular mass 68 kDa) release rate from polymer films was studied. Potato starch and potato starch acetates (SA), having a degree of substitution of 1.9 or 2.6, were investigated. Polymer films were incubated in phosphate buffer solution pH 7.4 in the absence and presence of enzymes (-amylase, amyloglucosidase, esterase) or in human serum. The acetylation of potato starch decreased its swelling considerably. Increased acetylation of starch also considerably retarded its enzymatic degradation. Due to the decreased swelling and degradation of SA films, BSA was released much slower from SA films than from potato starch films, both in the presence and absence of enzymes.

Original language	English
Pages (from-to)	284-290
Journal	Biomacromolecules
Volume	3
Issue number	2
DOIs	https://doi.org/10.1021/bm015581e
Publication status	Published - 2002
MoE publication type	A1 Journal article-refereed

Keywords

biodegradation
polymers
starch
potato
pharmaceutical compounds
drug delivery systems
amylose
amylopectin
acetylation

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title = "Enzymatic degradation of and bovine serum albumin release from starch-acetate films",

abstract = "The effect of acetylation of potato starch on swelling, enzymatic degradation, and bovine serum albumin (BSA, molecular mass 68 kDa) release rate from polymer films was studied. Potato starch and potato starch acetates (SA), having a degree of substitution of 1.9 or 2.6, were investigated. Polymer films were incubated in phosphate buffer solution pH 7.4 in the absence and presence of enzymes (-amylase, amyloglucosidase, esterase) or in human serum. The acetylation of potato starch decreased its swelling considerably. Increased acetylation of starch also considerably retarded its enzymatic degradation. Due to the decreased swelling and degradation of SA films, BSA was released much slower from SA films than from potato starch films, both in the presence and absence of enzymes.",

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author = "Laura Tuovinen and Soili Peltonen and Tapani Suortti and Nicholas Crowther and Matti Elomaa and Kristiina J{\"a}rvinen",

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doi = "10.1021/bm015581e",

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TY - JOUR

T1 - Enzymatic degradation of and bovine serum albumin release from starch-acetate films

AU - Tuovinen, Laura

AU - Peltonen, Soili

AU - Suortti, Tapani

AU - Crowther, Nicholas

AU - Elomaa, Matti

AU - Järvinen, Kristiina

PY - 2002

Y1 - 2002

N2 - The effect of acetylation of potato starch on swelling, enzymatic degradation, and bovine serum albumin (BSA, molecular mass 68 kDa) release rate from polymer films was studied. Potato starch and potato starch acetates (SA), having a degree of substitution of 1.9 or 2.6, were investigated. Polymer films were incubated in phosphate buffer solution pH 7.4 in the absence and presence of enzymes (-amylase, amyloglucosidase, esterase) or in human serum. The acetylation of potato starch decreased its swelling considerably. Increased acetylation of starch also considerably retarded its enzymatic degradation. Due to the decreased swelling and degradation of SA films, BSA was released much slower from SA films than from potato starch films, both in the presence and absence of enzymes.

AB - The effect of acetylation of potato starch on swelling, enzymatic degradation, and bovine serum albumin (BSA, molecular mass 68 kDa) release rate from polymer films was studied. Potato starch and potato starch acetates (SA), having a degree of substitution of 1.9 or 2.6, were investigated. Polymer films were incubated in phosphate buffer solution pH 7.4 in the absence and presence of enzymes (-amylase, amyloglucosidase, esterase) or in human serum. The acetylation of potato starch decreased its swelling considerably. Increased acetylation of starch also considerably retarded its enzymatic degradation. Due to the decreased swelling and degradation of SA films, BSA was released much slower from SA films than from potato starch films, both in the presence and absence of enzymes.

KW - biodegradation

KW - polymers

KW - starch

KW - potato

KW - pharmaceutical compounds

KW - drug delivery systems

KW - amylose

KW - amylopectin

KW - acetylation

U2 - 10.1021/bm015581e

DO - 10.1021/bm015581e

M3 - Article

SN - 1525-7797

VL - 3

SP - 284

EP - 290

JO - Biomacromolecules

JF - Biomacromolecules

IS - 2

ER -

Enzymatic degradation of and bovine serum albumin release from starch-acetate films

Abstract

Keywords

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