Enzymatic degradation of and bovine serum albumin release from starch-acetate films

Laura Tuovinen (Corresponding Author), Soili Peltonen, Tapani Suortti, Nicholas Crowther, Matti Elomaa, Kristiina Järvinen

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13 Citations (Scopus)

Abstract

The effect of acetylation of potato starch on swelling, enzymatic degradation, and bovine serum albumin (BSA, molecular mass 68 kDa) release rate from polymer films was studied. Potato starch and potato starch acetates (SA), having a degree of substitution of 1.9 or 2.6, were investigated. Polymer films were incubated in phosphate buffer solution pH 7.4 in the absence and presence of enzymes (-amylase, amyloglucosidase, esterase) or in human serum. The acetylation of potato starch decreased its swelling considerably. Increased acetylation of starch also considerably retarded its enzymatic degradation. Due to the decreased swelling and degradation of SA films, BSA was released much slower from SA films than from potato starch films, both in the presence and absence of enzymes.
Original languageEnglish
Pages (from-to)284-290
JournalBiomacromolecules
Volume3
Issue number2
DOIs
Publication statusPublished - 2002
MoE publication typeA1 Journal article-refereed

Keywords

  • biodegradation
  • polymers
  • starch
  • potato
  • pharmaceutical compounds
  • drug delivery systems
  • amylose
  • amylopectin
  • acetylation

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    Tuovinen, L., Peltonen, S., Suortti, T., Crowther, N., Elomaa, M., & Järvinen, K. (2002). Enzymatic degradation of and bovine serum albumin release from starch-acetate films. Biomacromolecules, 3(2), 284-290. https://doi.org/10.1021/bm015581e