Equivalence of metabolite fragments and flow analysis of isotopomer distributions for flux estimation

Ari Rantanen, Hannu Maaheimo, Esa Pitkänen, Juho Rousu, Esko Ukkonen

    Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

    1 Citation (Scopus)

    Abstract

    The most accurate estimates of the activity of metabolic pathways are obtained by conducting isotopomer tracer experiments. The success of this method, however, is intimately dependent on the quality and amount of data on isotopomer distributions of intermediate metabolites. In this paper we present a novel method for discovering sets of metabolite fragments that always have identical isotopomer distributions, regardless of the velocities of the reactions in the metabolic network. We outline several applications of this equivalence concept, including improved propagation of measurements, experiment planning and consistency checking of metabolic network. Our computational experiments in measurement propagation indicate that the improvement via the use of this technique may be substantial.
    Original languageEnglish
    Title of host publicationTransactions on Computational Systems Biology VI
    EditorsCorrado Priami, Gordon Plotkin
    Place of PublicationBerlin - Heidelberg
    PublisherSpringer
    Pages198-220
    ISBN (Electronic)978-3-540-46236-1
    ISBN (Print)978-3-540-45779-4
    DOIs
    Publication statusPublished - 2006
    MoE publication typeA4 Article in a conference publication

    Publication series

    SeriesTransactions on Computational Systems Biology
    VolumeVI
    ISSN1861-2075
    SeriesLecture Notes in Computer Science
    Volume4420
    ISSN0302-9743

    Fingerprint Dive into the research topics of 'Equivalence of metabolite fragments and flow analysis of isotopomer distributions for flux estimation'. Together they form a unique fingerprint.

    Cite this