The most accurate estimates of the activity of metabolic pathways are obtained by conducting isotopomer tracer experiments. The success of this method, however, is intimately dependent on the quality and amount of data on isotopomer distributions of intermediate metabolites. In this paper we present a novel method for discovering sets of metabolite fragments that always have identical isotopomer distributions, regardless of the velocities of the reactions in the metabolic network. We outline several applications of this equivalence concept, including improved propagation of measurements, experiment planning and consistency checking of metabolic network. Our computational experiments in measurement propagation indicate that the improvement via the use of this technique may be substantial.
|Title of host publication||Transactions on Computational Systems Biology VI|
|Editors||Corrado Priami, Gordon Plotkin|
|Place of Publication||Berlin - Heidelberg|
|Publication status||Published - 2006|
|MoE publication type||A4 Article in a conference publication|
|Series||Transactions on Computational Systems Biology|
|Series||Lecture Notes in Computer Science|