Establishing dose planning in BNCT at the Finnish facility

Tiina Seppälä, Iiro Auterinen, Sauli Savolainen

    Research output: Chapter in Book/Report/Conference proceedingConference abstract in proceedingsScientific

    Abstract

    The clinical trials of glioma patients with boron neutron capture therapy (BNCT) started in May 1999 at the Finnish Research Reactor (FiR 1). Epithermal neutrons are used with boronophenylalanine-fructose (BPA-F) as the 10B carrier. Before the clinical trials the dose planning system was established. The aim of the study was to 1) determine the FiR 1 epithermal neutron beam model 2) define the most suitable normal brain tissue material for NCT dosimetry 3) verify and normalise the beam model for clinical use 4) study the reliability of computational BNCT dose planning under in vivo conditions. The FiR 1 beam was modelled using DORT (Two Dimensional Discrete Ordinates Transport) code. The beam model was defined for the BNCT treatment planning program BNCT/Rtpe and its new version SERA (both INEEL/MSU, USA). The dosimetric characteristics of PMMA, water and two ICRU brain equivalent liquids as a phantom material were studied with computations to find a most suitable brain tissue sustitute for NCT dosimetry. The spectrum of the neutron beam model was verified in air with activation measurements. The neutron fluence/dose and gamma dose distributions in-phantoms were verified with activation dosimeters, ionisation chambers and TL dosemeters. The beam model of the treatment planning program was normalised to the measurements (activation foils) at the thermal neutron maximum in the PMMA phantom. The uncertainty of calculated reference doses are estimated in the brain with computational methods and around the brain with comparison to the measured values (activation foils and TL dosemeters) under in vivo conditions. The features of the dose planning system developed in the Finnish BNCT project will be exemplified by the treatment plans of the treated patients. [1] T.Serén, I.Auterinen, T.Seppälä, P.Kotiluoto, 15th European TRIGA Conference, (1999) 167. [2] T.Seppälä, T.Serén, I.Auterinen, Frontiers in Neutron Capture Therapy (2001) 219. [3] T.Seppälä, J.Vähätalo, I.Auterinen, A.Kosunen, D.W.Nigg, F.J.Wheeler, Radiat. Phys. Chem. (1999) 239. [4] A.Kosunen, M.Kortesniemi, H.Ylä-Mella, T.Seppälä, J.Lampinen, T.Serén, I.Auterinen, S.Savolainen, Radiat. Prot. Dosim. (1999) 187. [5] C.Aschan, M.Toivonen, S.Savolainen, T.Seppälä, I.Auterinen, Radiat. Prot. Dosim. (1999) 47. [6] T.Seppälä, I.Auterinen, C.Aschan, T.Serén, J.Benczik, M.Snellman, R.Huiskamp, U.Abo Ramadan, L.Kankaanranta, H.Joensuu, S.Savolainen, (under revision).
    Original languageEnglish
    Title of host publicationProceedings of the XXXVI Annual Conference of the Finnish Physical Society
    Place of PublicationJoensuu
    PublisherUniversity of Joensuu
    ISBN (Print)952-458-110-2
    Publication statusPublished - 2002
    MoE publication typeNot Eligible
    EventXXXVI Annual Conference of the Finnish Physical Society - Joensuu, Finland
    Duration: 13 Mar 200216 Mar 2002
    Conference number: 36

    Publication series

    SeriesSelected papers. University of Joensuu, Department of Physics
    Number7
    ISSN1236-0376

    Conference

    ConferenceXXXVI Annual Conference of the Finnish Physical Society
    CountryFinland
    CityJoensuu
    Period13/03/0216/03/02

    Fingerprint Dive into the research topics of 'Establishing dose planning in BNCT at the Finnish facility'. Together they form a unique fingerprint.

  • Cite this

    Seppälä, T., Auterinen, I., & Savolainen, S. (2002). Establishing dose planning in BNCT at the Finnish facility. In Proceedings of the XXXVI Annual Conference of the Finnish Physical Society [152] University of Joensuu. Selected papers. University of Joensuu, Department of Physics, No. 7