Abstract
Results: Cognitive tests had good performance in separating any type of dementia from controls. Cerebrospinal fluid optimally contributed to identifying Alzheimer's disease, whereas magnetic resonance imaging features aided in separating vascular dementia, dementia with Lewy bodies, and frontotemporal dementia. Combining diagnostic tests increased the accuracy, with balanced accuracies ranging from 78% to 97%.
Discussion: Different diagnostic tests have their distinct roles in differential diagnostics of dementias. Our results indicate that combining different diagnostic tests may increase the accuracy further.
Original language | English |
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Pages (from-to) | 509-518 |
Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 10 |
DOIs | |
Publication status | Published - 1 Jan 2018 |
MoE publication type | Not Eligible |
Funding
This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreements no 611005 (PredictND). For development of the PredictND tool, the VTT Technical Research Center of Finland Ltd has received funding from European Union's Seventh Framework Programme for research, technological development, and demonstration under grant agreements 601055 (VPH-DARE@IT), 224328, and 611005. F.B. is supported by the NIHR UCLH Biomedical Research Centre. P.S. received funding for travel from Pfizer, Elan, Janssen, and Danone Research. J.L. and J.K. are shareholders in Combinostics Oy. W.M.v.d.F. performs contract research for Biogen. Research programs of W.M.v.d.F. have been funded by ZonMW, NWO, EU-FP7, Alzheimer Nederland, CardioVascular Onderzoek Nederland, Stichting Dioraphte, Gieskes-Strijbis fonds, Boehringer Ingelheim, Piramal Neuroimaging, Roche BV, Janssen Stellar, and Combinostics. All funding is paid to her institution.
Keywords
- Alzheimer's disease
- Biomarkers
- Clinical decision support system
- CSF
- Dementia with Lewy bodies
- Diagnostic test assessment
- Differential diagnosis
- Frontotemporal dementia
- MRI
- Vascular dementia