Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging

Riku Klén (Corresponding Author), Tommi Noponen, Juha Koikkalainen, Jyrki Lötjönen, Kris Thielemans, Erika Hoppela, Hannu Sipilä, Mika Teräs, Juhani Knuuti

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43%, increased the contrast-to-noise ratio on average 6.0% and reduced the target size on average 10%. Slightly better figures (51, 6.9 and 28%) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43%) and the CT/PET-based method (61, 74 and 52%). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.
Original languageEnglish
Pages (from-to)956-968
JournalNuclear Medicine Communications
Volume37
Issue number9
DOIs
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

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Tomography
Artifacts
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Noise
Myocardium
Electrocardiography

Keywords

  • cardiac positron emission tomography imaging
  • dual gating
  • motion correction

Cite this

Klén, R., Noponen, T., Koikkalainen, J., Lötjönen, J., Thielemans, K., Hoppela, E., ... Knuuti, J. (2016). Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. Nuclear Medicine Communications, 37(9), 956-968. https://doi.org/10.1097/MNM.0000000000000539
Klén, Riku ; Noponen, Tommi ; Koikkalainen, Juha ; Lötjönen, Jyrki ; Thielemans, Kris ; Hoppela, Erika ; Sipilä, Hannu ; Teräs, Mika ; Knuuti, Juhani. / Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. In: Nuclear Medicine Communications. 2016 ; Vol. 37, No. 9. pp. 956-968.
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title = "Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging",
abstract = "BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43{\%}, increased the contrast-to-noise ratio on average 6.0{\%} and reduced the target size on average 10{\%}. Slightly better figures (51, 6.9 and 28{\%}) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43{\%}) and the CT/PET-based method (61, 74 and 52{\%}). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.",
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Klén, R, Noponen, T, Koikkalainen, J, Lötjönen, J, Thielemans, K, Hoppela, E, Sipilä, H, Teräs, M & Knuuti, J 2016, 'Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging', Nuclear Medicine Communications, vol. 37, no. 9, pp. 956-968. https://doi.org/10.1097/MNM.0000000000000539

Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. / Klén, Riku (Corresponding Author); Noponen, Tommi; Koikkalainen, Juha; Lötjönen, Jyrki; Thielemans, Kris; Hoppela, Erika; Sipilä, Hannu; Teräs, Mika; Knuuti, Juhani.

In: Nuclear Medicine Communications, Vol. 37, No. 9, 2016, p. 956-968.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging

AU - Klén, Riku

AU - Noponen, Tommi

AU - Koikkalainen, Juha

AU - Lötjönen, Jyrki

AU - Thielemans, Kris

AU - Hoppela, Erika

AU - Sipilä, Hannu

AU - Teräs, Mika

AU - Knuuti, Juhani

N1 - CA2: BA1163 AU2: Lötjönen, Jyrki ISI: RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43%, increased the contrast-to-noise ratio on average 6.0% and reduced the target size on average 10%. Slightly better figures (51, 6.9 and 28%) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43%) and the CT/PET-based method (61, 74 and 52%). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.

AB - BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43%, increased the contrast-to-noise ratio on average 6.0% and reduced the target size on average 10%. Slightly better figures (51, 6.9 and 28%) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43%) and the CT/PET-based method (61, 74 and 52%). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.

KW - cardiac positron emission tomography imaging

KW - dual gating

KW - motion correction

U2 - 10.1097/MNM.0000000000000539

DO - 10.1097/MNM.0000000000000539

M3 - Article

VL - 37

SP - 956

EP - 968

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 9

ER -