Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging

Riku Klén (Corresponding Author), Tommi Noponen, Juha Koikkalainen, Jyrki Lötjönen, Kris Thielemans, Erika Hoppela, Hannu Sipilä, Mika Teräs, Juhani Knuuti

    Research output: Contribution to journalArticleScientificpeer-review

    1 Citation (Scopus)

    Abstract

    BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43%, increased the contrast-to-noise ratio on average 6.0% and reduced the target size on average 10%. Slightly better figures (51, 6.9 and 28%) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43%) and the CT/PET-based method (61, 74 and 52%). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.
    Original languageEnglish
    Pages (from-to)956-968
    JournalNuclear Medicine Communications
    Volume37
    Issue number9
    DOIs
    Publication statusPublished - 2016
    MoE publication typeA1 Journal article-refereed

    Fingerprint

    Tomography
    Artifacts
    Positron Emission Tomography Computed Tomography
    Positron-Emission Tomography
    Noise
    Myocardium
    Electrocardiography

    Keywords

    • cardiac positron emission tomography imaging
    • dual gating
    • motion correction

    Cite this

    Klén, R., Noponen, T., Koikkalainen, J., Lötjönen, J., Thielemans, K., Hoppela, E., ... Knuuti, J. (2016). Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. Nuclear Medicine Communications, 37(9), 956-968. https://doi.org/10.1097/MNM.0000000000000539
    Klén, Riku ; Noponen, Tommi ; Koikkalainen, Juha ; Lötjönen, Jyrki ; Thielemans, Kris ; Hoppela, Erika ; Sipilä, Hannu ; Teräs, Mika ; Knuuti, Juhani. / Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. In: Nuclear Medicine Communications. 2016 ; Vol. 37, No. 9. pp. 956-968.
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    title = "Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging",
    abstract = "BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43{\%}, increased the contrast-to-noise ratio on average 6.0{\%} and reduced the target size on average 10{\%}. Slightly better figures (51, 6.9 and 28{\%}) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43{\%}) and the CT/PET-based method (61, 74 and 52{\%}). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.",
    keywords = "cardiac positron emission tomography imaging, dual gating, motion correction",
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    Klén, R, Noponen, T, Koikkalainen, J, Lötjönen, J, Thielemans, K, Hoppela, E, Sipilä, H, Teräs, M & Knuuti, J 2016, 'Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging', Nuclear Medicine Communications, vol. 37, no. 9, pp. 956-968. https://doi.org/10.1097/MNM.0000000000000539

    Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. / Klén, Riku (Corresponding Author); Noponen, Tommi; Koikkalainen, Juha; Lötjönen, Jyrki; Thielemans, Kris; Hoppela, Erika; Sipilä, Hannu; Teräs, Mika; Knuuti, Juhani.

    In: Nuclear Medicine Communications, Vol. 37, No. 9, 2016, p. 956-968.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging

    AU - Klén, Riku

    AU - Noponen, Tommi

    AU - Koikkalainen, Juha

    AU - Lötjönen, Jyrki

    AU - Thielemans, Kris

    AU - Hoppela, Erika

    AU - Sipilä, Hannu

    AU - Teräs, Mika

    AU - Knuuti, Juhani

    N1 - CA2: BA1163 AU2: Lötjönen, Jyrki ISI: RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

    PY - 2016

    Y1 - 2016

    N2 - BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43%, increased the contrast-to-noise ratio on average 6.0% and reduced the target size on average 10%. Slightly better figures (51, 6.9 and 28%) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43%) and the CT/PET-based method (61, 74 and 52%). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.

    AB - BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43%, increased the contrast-to-noise ratio on average 6.0% and reduced the target size on average 10%. Slightly better figures (51, 6.9 and 28%) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43%) and the CT/PET-based method (61, 74 and 52%). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.

    KW - cardiac positron emission tomography imaging

    KW - dual gating

    KW - motion correction

    U2 - 10.1097/MNM.0000000000000539

    DO - 10.1097/MNM.0000000000000539

    M3 - Article

    VL - 37

    SP - 956

    EP - 968

    JO - Nuclear Medicine Communications

    JF - Nuclear Medicine Communications

    SN - 0143-3636

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