Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4

M. Andberg, M. Hamberg, J.Z. Haeggström

Research output: Chapter in Book/Report/Conference proceedingChapter or book articleScientificpeer-review

1 Citation (Scopus)

Abstract

Leukotriene (LT) A4 hydrolase is a soluble enzyme that catalyzes the production of 5S,12R-dihydroxy-6, 14-cis-8,10-trans-eicosatetraenoic acid (LTB4) from the transient allylic epoxide 5S-trans-5, 6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid (LTA4). LTB4 elicits chemotaxis and adherence of leukocytes in only nM concentrations and is regarded as an important chemical mediator in a variety of inflammatory disorders.
Original languageEnglish
Title of host publicationEicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury
EditorsKenneth V. Honn, Lawrence J. Marnett, Santosh Nigam, Edward A. Dennis
PublisherSpringer
ISBN (Electronic)978-1-4615-4793-8
ISBN (Print)978-1-4613-7171-7
DOIs
Publication statusPublished - 2000
MoE publication typeA3 Part of a book or another research book

Publication series

SeriesAdvances in Experimental Medicine and Biology
Volume469
ISSN0065-2598

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    Andberg, M., Hamberg, M., & Haeggström, J. Z. (2000). Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4. In K. V. Honn, L. J. Marnett, S. Nigam, & E. A. Dennis (Eds.), Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury Springer. Advances in Experimental Medicine and Biology, Vol.. 469 https://doi.org/10.1007/978-1-4615-4793-8_47