Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4

M. Andberg; M. Hamberg; J.Z. Haeggström

doi:10.1007/978-1-4615-4793-8_47

Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4

M. Andberg, M. Hamberg, J.Z. Haeggström

Not published at VTT

Research output: Chapter in Book/Report/Conference proceeding › Chapter or book article › Scientific › peer-review

1 Citation (Scopus)

Abstract

Leukotriene (LT) A4 hydrolase is a soluble enzyme that catalyzes the production of 5S,12R-dihydroxy-6, 14-cis-8,10-trans-eicosatetraenoic acid (LTB4) from the transient allylic epoxide 5S-trans-5, 6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid (LTA4). LTB4 elicits chemotaxis and adherence of leukocytes in only nM concentrations and is regarded as an important chemical mediator in a variety of inflammatory disorders.

Original language	English
Title of host publication	Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury
Editors	Kenneth V. Honn, Lawrence J. Marnett, Santosh Nigam, Edward A. Dennis
Publisher	Springer
ISBN (Electronic)	978-1-4615-4793-8
ISBN (Print)	978-1-4613-7171-7
DOIs	https://doi.org/10.1007/978-1-4615-4793-8_47
Publication status	Published - 2000
MoE publication type	A3 Part of a book or another research book

Publication series

Series	Advances in Experimental Medicine and Biology
Volume	469
ISSN	0065-2598

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Andberg, M., Hamberg, M., & Haeggström, J. Z. (2000). Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4. In K. V. Honn, L. J. Marnett, S. Nigam, & E. A. Dennis (Eds.), Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury Springer. Advances in Experimental Medicine and Biology Vol. 469 https://doi.org/10.1007/978-1-4615-4793-8_47

Andberg, M. ; Hamberg, M. ; Haeggström, J.Z. / Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury. editor / Kenneth V. Honn ; Lawrence J. Marnett ; Santosh Nigam ; Edward A. Dennis. Springer, 2000. (Advances in Experimental Medicine and Biology, Vol. 469).

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title = "Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4",

abstract = "Leukotriene (LT) A4 hydrolase is a soluble enzyme that catalyzes the production of 5S,12R-dihydroxy-6, 14-cis-8,10-trans-eicosatetraenoic acid (LTB4) from the transient allylic epoxide 5S-trans-5, 6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid (LTA4). LTB4 elicits chemotaxis and adherence of leukocytes in only nM concentrations and is regarded as an important chemical mediator in a variety of inflammatory disorders.",

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language = "English",

isbn = "978-1-4613-7171-7",

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Andberg, M, Hamberg, M & Haeggström, JZ 2000, Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4. in KV Honn, LJ Marnett, S Nigam & EA Dennis (eds), Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury. Springer, Advances in Experimental Medicine and Biology, vol. 469. https://doi.org/10.1007/978-1-4615-4793-8_47

Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4. / Andberg, M.; Hamberg, M.; Haeggström, J.Z.

Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury. ed. / Kenneth V. Honn; Lawrence J. Marnett; Santosh Nigam; Edward A. Dennis. Springer, 2000. (Advances in Experimental Medicine and Biology, Vol. 469).

Research output: Chapter in Book/Report/Conference proceeding › Chapter or book article › Scientific › peer-review

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AB - Leukotriene (LT) A4 hydrolase is a soluble enzyme that catalyzes the production of 5S,12R-dihydroxy-6, 14-cis-8,10-trans-eicosatetraenoic acid (LTB4) from the transient allylic epoxide 5S-trans-5, 6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid (LTA4). LTB4 elicits chemotaxis and adherence of leukocytes in only nM concentrations and is regarded as an important chemical mediator in a variety of inflammatory disorders.

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DO - 10.1007/978-1-4615-4793-8_47

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SN - 978-1-4613-7171-7

T3 - Advances in Experimental Medicine and Biology

BT - Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury

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A2 - Marnett, Lawrence J.

A2 - Nigam, Santosh

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Andberg M, Hamberg M, Haeggström JZ. Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4. In Honn KV, Marnett LJ, Nigam S, Dennis EA, editors, Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury. Springer. 2000. (Advances in Experimental Medicine and Biology, Vol. 469). https://doi.org/10.1007/978-1-4615-4793-8_47

Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4

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