Expression system for eukaryotic organisms

Dominik Mojzita (Inventor), Anssi Rantasalo (Inventor), Jussi Jäntti (Inventor), Christopher Landowski (Inventor), Joosu Kuivanen (Inventor)

    Research output: PatentPatent


    The present invention provides an expression system for a eukaryotic host, which comprises 1) an expression cassette comprising a core promoter, said core promoter controlling the expression of a DNA sequence encoding a synthetic transcription factor (sTF), and 2) one or more expression cassettes each comprising a DNA sequence encoding a desired product operably linked to a synthetic promoter, said synthetic promoter comprising a core promoter, and sTF-specific binding sites upstream of the core promoter. The present invention also provides a method for identifying universal core promoters for eukaryotic hosts, expression systems using universal core promoters, hosts comprising said systems, and methods for producing protein products in eukaryotic hosts.

    Patent family as of 10.12.2021
    AU2017224865 AA 20180913 AU20170224865 20170221      
    BR112018017088 A2 20190102 BR20181117088 20170221      
    CA3015440 AA 20180822 CA20173015440 20170221      
    CN109477115 A 20190315 CN201780020813 20170221      
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    ES2870962 T3 20211028 ES20170712530T 20170221      
    FI127283 B 20180315 FI20160005137 20160222      
    FI20165137 A 20170823 FI20160005137 20160222      
    HU054884 T2 20211028 HU20170712530T 20170221      
    IN201847035224 A 20180928 IN201847035224 20180919      
    JP2019505230 T2 20190228 JP20180544246T 20170221      
    JP6953667 B2 20211027 JP20180544246T 20170221      
    KR20180117147 A 20181026 KR20187027693 20170221      
    LT3405580 T 20210810 LT20170712530T 20170221      
    MX2018010055 A1 20181109 MX20180010055 20170221      
    PT3405580 T 20210521 PT20170712530T 20170221      
    US2018371468 AA 20181227 US20170737696 20170221      
    WO17144777 A1 20170831 WO2017FI50114 20170221

    Link to current patent family on right 

    Original languageEnglish
    Patent numberEP3405580
    IPCC12N 15/ 79 A I
    Priority date21/02/17
    Publication statusPublished - 28 Nov 2018
    MoE publication typeH1 Granted patent


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