Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans

Elin Hålldin, Anne Kirstine Eriksen, Carl Brunius, Andreia Bento da Silva, Maria Bronze, Kati Hanhineva, Anna Marja Aura, Rikard Landberg (Corresponding Author)

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

Lignans are diphenolic plant compounds with potential health modulating properties that are absorbed to the circulation and metabolized to the enterolignans enterodiol (END) and enterolactone (ENL) by gut microbiota. Epidemiological studies have inconsistently shown that a high lignan intake and circulating ENL are associated with reduced risk of breast-, prostate-, and colorectal cancer as well as cardiovascular disease and total and cause-specific mortality. Inconsistencies can be due to interpersonal variation of ENL formation or responses. The aim of this review is to identify and evaluate the impact of factors influencing variability in plasma concentrations of the main enterolignan, ENL. The main determinants of plasma ENL concentrations are intake of lignan and lignan-rich foods, composition and activity of intestinal microflora, antimicrobial use, nutrient intake, BMI, smoking, sex, and age. Composition and activity of the intestinal microbiota appear to be the most critical factor governing interpersonal variability in plasma ENL concentration followed by the use of antibiotics. Future studies with combined data from gut microbiota and metabolomics with food intake and life style data can be used to estimate the relative contribution of the different factors to ENL concentration in quantitative terms.

Original languageEnglish
Article number1801159
JournalMolecular Nutrition and Food Research
Volume63
Issue number16
DOIs
Publication statusPublished - 28 Feb 2019
MoE publication typeA2 Review article in a scientific journal

Fingerprint

lignans
intestinal microorganisms
Lignans
food composition
smoking (food products)
metabolomics
prostatic neoplasms
colorectal neoplasms
nutrient intake
epidemiological studies
cardiovascular diseases
lifestyle
breasts
food intake
anti-infective agents
antibiotics
Food
Metabolomics
2,3-bis(3'-hydroxybenzyl)butyrolactone
gender

Keywords

  • determinants
  • enterolactone
  • interpersonal variation
  • lignans
  • plasma

Cite this

Hålldin, E., Eriksen, A. K., Brunius, C., da Silva, A. B., Bronze, M., Hanhineva, K., ... Landberg, R. (2019). Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans. Molecular Nutrition and Food Research, 63(16), [1801159]. https://doi.org/10.1002/mnfr.201801159
Hålldin, Elin ; Eriksen, Anne Kirstine ; Brunius, Carl ; da Silva, Andreia Bento ; Bronze, Maria ; Hanhineva, Kati ; Aura, Anna Marja ; Landberg, Rikard. / Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans. In: Molecular Nutrition and Food Research. 2019 ; Vol. 63, No. 16.
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Hålldin, E, Eriksen, AK, Brunius, C, da Silva, AB, Bronze, M, Hanhineva, K, Aura, AM & Landberg, R 2019, 'Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans', Molecular Nutrition and Food Research, vol. 63, no. 16, 1801159. https://doi.org/10.1002/mnfr.201801159

Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans. / Hålldin, Elin; Eriksen, Anne Kirstine; Brunius, Carl; da Silva, Andreia Bento; Bronze, Maria; Hanhineva, Kati; Aura, Anna Marja; Landberg, Rikard (Corresponding Author).

In: Molecular Nutrition and Food Research, Vol. 63, No. 16, 1801159, 28.02.2019.

Research output: Contribution to journalReview ArticleScientificpeer-review

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