Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes

Vanessa De Mello, Maria Lankinen, Jaana Lindström, Riitta Puupponen-Pimiä, David Laaksonen, Jussi Pihlajamäki, Marko Lehtonen, Matti Uusitupa, Jaakko Tuomilehto, Marjukka Kolehmainen, Riitta Törrönen, Kati Hanhineva

Research output: Contribution to journalArticleScientificpeer-review

8 Citations (Scopus)

Abstract

Scope: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198). Conclusion: Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.

Original languageEnglish
Article number1700019
JournalMolecular Nutrition and Food Research
Volume61
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017
MoE publication typeA1 Journal article-refereed

Fingerprint

Vaccinium myrtillus
hippuric acid
bilberries
insulin secretion
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
fasting
Fasting
Anthocyanins
Insulin
Diet
Glucose
glucose
anthocyanins
Serum
diet
Fruit
Rubus chamaemorus
Fragaria
glycemic control

Keywords

  • bilberry
  • glucose metabolism
  • hippuric acid
  • LC-MS
  • vaccinium myrtillus

Cite this

De Mello, Vanessa ; Lankinen, Maria ; Lindström, Jaana ; Puupponen-Pimiä, Riitta ; Laaksonen, David ; Pihlajamäki, Jussi ; Lehtonen, Marko ; Uusitupa, Matti ; Tuomilehto, Jaakko ; Kolehmainen, Marjukka ; Törrönen, Riitta ; Hanhineva, Kati. / Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. In: Molecular Nutrition and Food Research. 2017 ; Vol. 61, No. 9.
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title = "Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes",
abstract = "Scope: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198). Conclusion: Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.",
keywords = "bilberry, glucose metabolism, hippuric acid, LC-MS, vaccinium myrtillus",
author = "{De Mello}, Vanessa and Maria Lankinen and Jaana Lindstr{\"o}m and Riitta Puupponen-Pimi{\"a} and David Laaksonen and Jussi Pihlajam{\"a}ki and Marko Lehtonen and Matti Uusitupa and Jaakko Tuomilehto and Marjukka Kolehmainen and Riitta T{\"o}rr{\"o}nen and Kati Hanhineva",
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Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. / De Mello, Vanessa; Lankinen, Maria; Lindström, Jaana; Puupponen-Pimiä, Riitta; Laaksonen, David; Pihlajamäki, Jussi; Lehtonen, Marko; Uusitupa, Matti; Tuomilehto, Jaakko; Kolehmainen, Marjukka; Törrönen, Riitta; Hanhineva, Kati.

In: Molecular Nutrition and Food Research, Vol. 61, No. 9, 1700019, 01.09.2017.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes

AU - De Mello, Vanessa

AU - Lankinen, Maria

AU - Lindström, Jaana

AU - Puupponen-Pimiä, Riitta

AU - Laaksonen, David

AU - Pihlajamäki, Jussi

AU - Lehtonen, Marko

AU - Uusitupa, Matti

AU - Tuomilehto, Jaakko

AU - Kolehmainen, Marjukka

AU - Törrönen, Riitta

AU - Hanhineva, Kati

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Scope: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198). Conclusion: Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.

AB - Scope: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198). Conclusion: Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.

KW - bilberry

KW - glucose metabolism

KW - hippuric acid

KW - LC-MS

KW - vaccinium myrtillus

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U2 - 10.1002/mnfr.201700019

DO - 10.1002/mnfr.201700019

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