TY - JOUR
T1 - Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
AU - De Mello, Vanessa
AU - Lankinen, Maria
AU - Lindström, Jaana
AU - Puupponen-Pimiä, Riitta
AU - Laaksonen, David
AU - Pihlajamäki, Jussi
AU - Lehtonen, Marko
AU - Uusitupa, Matti
AU - Tuomilehto, Jaakko
AU - Kolehmainen, Marjukka
AU - Törrönen, Riitta
AU - Hanhineva, Kati
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Scope: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198). Conclusion: Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.
AB - Scope: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198). Conclusion: Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.
KW - bilberry
KW - glucose metabolism
KW - hippuric acid
KW - LC-MS
KW - vaccinium myrtillus
UR - http://www.scopus.com/inward/record.url?scp=85024502097&partnerID=8YFLogxK
U2 - 10.1002/mnfr.201700019
DO - 10.1002/mnfr.201700019
M3 - Article
SN - 1613-4125
VL - 61
JO - Molecular Nutrition and Food Research
JF - Molecular Nutrition and Food Research
IS - 9
M1 - 1700019
ER -