Abstract
Scope: Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism. Methods and results: Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = –0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198). Conclusion: Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.
Original language | English |
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Article number | 1700019 |
Journal | Molecular Nutrition and Food Research |
Volume | 61 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Sept 2017 |
MoE publication type | A1 Journal article-refereed |
Funding
This study was funded by the Academy of Finland (128315, 129330, 131593, and 133431), the Finnish Funding Agency for Technology and Innovation (Tekes 40361/05), the Finnish Diabetes Research Foundation, Finnish Cultural Foundation North-Savo Regional fund, and the Biocenter Finland.
Keywords
- bilberry
- glucose metabolism
- hippuric acid
- LC-MS
- vaccinium myrtillus