Fatty fish intake decreases lipids related to inflammation and insulin signaling

A lipidomics approach

Maria Lankinen, Ursula Schwab, Anja Erkkilä, Tuulikki Seppänen-Laakso, Marja-Leena Hannila, Hanna Mussalo, Seppo Lehto, Matti Uusitupa, Helena Gylling, Matej Orešič (Corresponding Author)

Research output: Contribution to journalArticleScientificpeer-review

84 Citations (Scopus)

Abstract

Background

The evidence of the multiple beneficial health effects of fish consumption is strong, but physiological mechanisms behind these effects are not completely known. Little information is available on the effects of consumption of different type of fish. The aim of this study was to investigate how fatty fish or lean fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease.

Methodology and Principal Findings

A pilot study was designed which included altogether 33 subjects with myocardial infarction or unstable ischemic attack in an 8-week parallel controlled intervention. The subjects were randomized to either fatty fish (n = 11), lean fish (n = 12) or control (n = 10) groups. Subjects in the fish groups had 4 fish meals per week and subjects in the control group consumed lean beef, pork and chicken. A fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcholines and diacylglycerols, decreased significantly in the fatty fish group, whereas in the lean fish group cholesterol esters and specific long-chain triacylglycerols increased significantly (False Discovery Rate q-value <0.05).

Conclusions/Significance

The 8-week consumption of fatty fish decreased lipids which are potential mediators of lipid-induced insulin resistance and inflammation, and may be related to the protective effects of fatty fish on the progression of atherosclerotic vascular diseases or insulin resistance.

Original languageEnglish
Article numbere5258
Number of pages9
JournalPLoS ONE
Volume4
Issue number4
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fingerprint

fatty fish
fat intake
Fish
Fishes
insulin
inflammation
lean fish
Insulin
Inflammation
Lipids
fish meal
insulin resistance
lipids
long chain triacylglycerols
ultra-performance liquid chromatography
lysophosphatidylcholine
vascular diseases
ceramides
fish consumption
cholesteryl esters

Cite this

Lankinen, Maria ; Schwab, Ursula ; Erkkilä, Anja ; Seppänen-Laakso, Tuulikki ; Hannila, Marja-Leena ; Mussalo, Hanna ; Lehto, Seppo ; Uusitupa, Matti ; Gylling, Helena ; Orešič, Matej. / Fatty fish intake decreases lipids related to inflammation and insulin signaling : A lipidomics approach. In: PLoS ONE. 2009 ; Vol. 4, No. 4.
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title = "Fatty fish intake decreases lipids related to inflammation and insulin signaling: A lipidomics approach",
abstract = "BackgroundThe evidence of the multiple beneficial health effects of fish consumption is strong, but physiological mechanisms behind these effects are not completely known. Little information is available on the effects of consumption of different type of fish. The aim of this study was to investigate how fatty fish or lean fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease.Methodology and Principal FindingsA pilot study was designed which included altogether 33 subjects with myocardial infarction or unstable ischemic attack in an 8-week parallel controlled intervention. The subjects were randomized to either fatty fish (n = 11), lean fish (n = 12) or control (n = 10) groups. Subjects in the fish groups had 4 fish meals per week and subjects in the control group consumed lean beef, pork and chicken. A fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcholines and diacylglycerols, decreased significantly in the fatty fish group, whereas in the lean fish group cholesterol esters and specific long-chain triacylglycerols increased significantly (False Discovery Rate q-value <0.05).Conclusions/SignificanceThe 8-week consumption of fatty fish decreased lipids which are potential mediators of lipid-induced insulin resistance and inflammation, and may be related to the protective effects of fatty fish on the progression of atherosclerotic vascular diseases or insulin resistance.",
author = "Maria Lankinen and Ursula Schwab and Anja Erkkil{\"a} and Tuulikki Sepp{\"a}nen-Laakso and Marja-Leena Hannila and Hanna Mussalo and Seppo Lehto and Matti Uusitupa and Helena Gylling and Matej Orešič",
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Lankinen, M, Schwab, U, Erkkilä, A, Seppänen-Laakso, T, Hannila, M-L, Mussalo, H, Lehto, S, Uusitupa, M, Gylling, H & Orešič, M 2009, 'Fatty fish intake decreases lipids related to inflammation and insulin signaling: A lipidomics approach', PLoS ONE, vol. 4, no. 4, e5258. https://doi.org/10.1371/journal.pone.0005258

Fatty fish intake decreases lipids related to inflammation and insulin signaling : A lipidomics approach. / Lankinen, Maria; Schwab, Ursula; Erkkilä, Anja; Seppänen-Laakso, Tuulikki; Hannila, Marja-Leena; Mussalo, Hanna; Lehto, Seppo; Uusitupa, Matti; Gylling, Helena; Orešič, Matej (Corresponding Author).

In: PLoS ONE, Vol. 4, No. 4, e5258, 2009.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Fatty fish intake decreases lipids related to inflammation and insulin signaling

T2 - A lipidomics approach

AU - Lankinen, Maria

AU - Schwab, Ursula

AU - Erkkilä, Anja

AU - Seppänen-Laakso, Tuulikki

AU - Hannila, Marja-Leena

AU - Mussalo, Hanna

AU - Lehto, Seppo

AU - Uusitupa, Matti

AU - Gylling, Helena

AU - Orešič, Matej

PY - 2009

Y1 - 2009

N2 - BackgroundThe evidence of the multiple beneficial health effects of fish consumption is strong, but physiological mechanisms behind these effects are not completely known. Little information is available on the effects of consumption of different type of fish. The aim of this study was to investigate how fatty fish or lean fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease.Methodology and Principal FindingsA pilot study was designed which included altogether 33 subjects with myocardial infarction or unstable ischemic attack in an 8-week parallel controlled intervention. The subjects were randomized to either fatty fish (n = 11), lean fish (n = 12) or control (n = 10) groups. Subjects in the fish groups had 4 fish meals per week and subjects in the control group consumed lean beef, pork and chicken. A fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcholines and diacylglycerols, decreased significantly in the fatty fish group, whereas in the lean fish group cholesterol esters and specific long-chain triacylglycerols increased significantly (False Discovery Rate q-value <0.05).Conclusions/SignificanceThe 8-week consumption of fatty fish decreased lipids which are potential mediators of lipid-induced insulin resistance and inflammation, and may be related to the protective effects of fatty fish on the progression of atherosclerotic vascular diseases or insulin resistance.

AB - BackgroundThe evidence of the multiple beneficial health effects of fish consumption is strong, but physiological mechanisms behind these effects are not completely known. Little information is available on the effects of consumption of different type of fish. The aim of this study was to investigate how fatty fish or lean fish in a diet affect serum lipidomic profiles in subjects with coronary heart disease.Methodology and Principal FindingsA pilot study was designed which included altogether 33 subjects with myocardial infarction or unstable ischemic attack in an 8-week parallel controlled intervention. The subjects were randomized to either fatty fish (n = 11), lean fish (n = 12) or control (n = 10) groups. Subjects in the fish groups had 4 fish meals per week and subjects in the control group consumed lean beef, pork and chicken. A fish meal was allowed once a week maximum. Lipidomics analyses were performed using ultra performance liquid chromatography coupled to electrospray ionization mass spectrometry and gas chromatography. Multiple bioactive lipid species, including ceramides, lysophosphatidylcholines and diacylglycerols, decreased significantly in the fatty fish group, whereas in the lean fish group cholesterol esters and specific long-chain triacylglycerols increased significantly (False Discovery Rate q-value <0.05).Conclusions/SignificanceThe 8-week consumption of fatty fish decreased lipids which are potential mediators of lipid-induced insulin resistance and inflammation, and may be related to the protective effects of fatty fish on the progression of atherosclerotic vascular diseases or insulin resistance.

U2 - 10.1371/journal.pone.0005258

DO - 10.1371/journal.pone.0005258

M3 - Article

VL - 4

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 4

M1 - e5258

ER -