Feasibility of glucose sensing by time- and spatial-resolved detection: Monte Carlo simulations of diffuse reflection in a three-layer skin model

Alexander V. Bykov, Alexey P. Popov, Alexander V. Priezzhev, Jukka Hast, Risto Myllylä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

In this paper, we investigate possibilities of glucose level monitoring in skin and blood within physiological range (0 - 500 mg/dl) by Monte Carlo simulations. The study was performed with a 3-layer plain phantom (5-mm thick) with optical properties of the layers taken from the literature. The superficial layer mimics the epidermis, the middle layer mimics the upper blood net dermis, and the deepest layer mimics the dermis of the skin. Diffuse reflected pulses from a pencil-beam laser source of 820 nm were registered by an array of coincident 0.3-mm thick rings with numerical apertures of 0.19. We show that for the used optical properties of the layers, the characteristics most sensitive to the variation of glucose level are the pulse energy and peak intensity for the source-detector separations of 1 to 3 mm. The relative change of these parameters is as high as 5-25%.

Original languageEnglish
Title of host publicationOptical Diagnostics and Sensing VI
EditorsGerard L. Coté, Alexander V. Priezzhev
PublisherInternational Society for Optics and Photonics SPIE
DOIs
Publication statusPublished - 29 Jun 2006
MoE publication typeA4 Article in a conference publication
EventOptical Diagnostics and Sensing VI - San Jose, United States
Duration: 24 Jan 200625 Jan 2006

Publication series

SeriesProgress in Biomedical Optics and Imaging
Number17
Volume7
ISSN1605-7422
SeriesProceedings of SPIE
Volume6094
ISSN0277-786X

Conference

ConferenceOptical Diagnostics and Sensing VI
CountryUnited States
CitySan Jose
Period24/01/0625/01/06

Keywords

  • Glucose
  • Human skin phantom
  • Monte Carlo simulation
  • Photon migration

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