Fiber-optic biosensor based on self-mixing interferometry

M. Määttälä, J. Laur, M. Kinnunen, Jukka Hast, R. Myllylä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

2 Citations (Scopus)

Abstract

Self-mixing interferometry is a promising technique for a variety of measurement applications. Using a laser diode with an external cavity as interferometer, the technique offers several advantages over traditional interferometric configurations. This research used a self-mixing interferometer built in our own laboratory. It is based on a blue emitting GaN laser diode with a wavelength of 405 nm. Light is directed through an optical fiber from which a 1-cm section of cladding has been removed, and a cuvette for holding the sample is fixed around this part. Interference patterns, created in the laser cavity, are acquired with a computer-based data acquisition system and later processed using Matlab software. Since samples with different refractive indices create interference patterns with different phases, even small changes in sample concentrations can be measured. However, coupling light into a single-mode optical fiber is a very challenging task, and the setup is very sensitive to external interference like airflows or vibrations. Experiments with the device showed that, in stability measurements, the standard deviation of the recorded fringe pattern shifts was only 1.7 nm. In sample measurements, the refractive index change in the sample chamber varied from 1.0029 to 1.33, corresponding to a fringe pattern shift of 297±4 nm.
Original languageEnglish
Title of host publicationSixth International Conference on Advanced Optical Materials and Devices (AOMD-6)
PublisherInternational Society for Optics and Photonics SPIE
DOIs
Publication statusPublished - 2008
MoE publication typeA4 Article in a conference publication
Event6th International Conference on Advanced Optical Materials and Devices, AOMD-6 -
Duration: 1 Jan 2008 → …

Publication series

SeriesProceedings of SPIE
Volume7142
ISSN0277-786X

Conference

Conference6th International Conference on Advanced Optical Materials and Devices, AOMD-6
Period1/01/08 → …

Fingerprint

bioinstrumentation
fiber optics
interferometry
interference
diffraction patterns
interferometers
optical fibers
semiconductor lasers
refractivity
shift
laser cavities
data acquisition
standard deviation
chambers
computer programs
vibration
cavities
configurations
wavelengths

Keywords

  • External cavity
  • Laser diode
  • Optical fiber
  • Refractive index change
  • Self-mixing interferometry

Cite this

Määttälä, M., Laur, J., Kinnunen, M., Hast, J., & Myllylä, R. (2008). Fiber-optic biosensor based on self-mixing interferometry. In Sixth International Conference on Advanced Optical Materials and Devices (AOMD-6) [71420I] International Society for Optics and Photonics SPIE. Proceedings of SPIE, Vol.. 7142 https://doi.org/10.1117/12.815269
Määttälä, M. ; Laur, J. ; Kinnunen, M. ; Hast, Jukka ; Myllylä, R. / Fiber-optic biosensor based on self-mixing interferometry. Sixth International Conference on Advanced Optical Materials and Devices (AOMD-6). International Society for Optics and Photonics SPIE, 2008. (Proceedings of SPIE, Vol. 7142).
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abstract = "Self-mixing interferometry is a promising technique for a variety of measurement applications. Using a laser diode with an external cavity as interferometer, the technique offers several advantages over traditional interferometric configurations. This research used a self-mixing interferometer built in our own laboratory. It is based on a blue emitting GaN laser diode with a wavelength of 405 nm. Light is directed through an optical fiber from which a 1-cm section of cladding has been removed, and a cuvette for holding the sample is fixed around this part. Interference patterns, created in the laser cavity, are acquired with a computer-based data acquisition system and later processed using Matlab software. Since samples with different refractive indices create interference patterns with different phases, even small changes in sample concentrations can be measured. However, coupling light into a single-mode optical fiber is a very challenging task, and the setup is very sensitive to external interference like airflows or vibrations. Experiments with the device showed that, in stability measurements, the standard deviation of the recorded fringe pattern shifts was only 1.7 nm. In sample measurements, the refractive index change in the sample chamber varied from 1.0029 to 1.33, corresponding to a fringe pattern shift of 297±4 nm.",
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Määttälä, M, Laur, J, Kinnunen, M, Hast, J & Myllylä, R 2008, Fiber-optic biosensor based on self-mixing interferometry. in Sixth International Conference on Advanced Optical Materials and Devices (AOMD-6)., 71420I, International Society for Optics and Photonics SPIE, Proceedings of SPIE, vol. 7142, 6th International Conference on Advanced Optical Materials and Devices, AOMD-6, 1/01/08. https://doi.org/10.1117/12.815269

Fiber-optic biosensor based on self-mixing interferometry. / Määttälä, M.; Laur, J.; Kinnunen, M.; Hast, Jukka; Myllylä, R.

Sixth International Conference on Advanced Optical Materials and Devices (AOMD-6). International Society for Optics and Photonics SPIE, 2008. 71420I (Proceedings of SPIE, Vol. 7142).

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

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AB - Self-mixing interferometry is a promising technique for a variety of measurement applications. Using a laser diode with an external cavity as interferometer, the technique offers several advantages over traditional interferometric configurations. This research used a self-mixing interferometer built in our own laboratory. It is based on a blue emitting GaN laser diode with a wavelength of 405 nm. Light is directed through an optical fiber from which a 1-cm section of cladding has been removed, and a cuvette for holding the sample is fixed around this part. Interference patterns, created in the laser cavity, are acquired with a computer-based data acquisition system and later processed using Matlab software. Since samples with different refractive indices create interference patterns with different phases, even small changes in sample concentrations can be measured. However, coupling light into a single-mode optical fiber is a very challenging task, and the setup is very sensitive to external interference like airflows or vibrations. Experiments with the device showed that, in stability measurements, the standard deviation of the recorded fringe pattern shifts was only 1.7 nm. In sample measurements, the refractive index change in the sample chamber varied from 1.0029 to 1.33, corresponding to a fringe pattern shift of 297±4 nm.

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Määttälä M, Laur J, Kinnunen M, Hast J, Myllylä R. Fiber-optic biosensor based on self-mixing interferometry. In Sixth International Conference on Advanced Optical Materials and Devices (AOMD-6). International Society for Optics and Photonics SPIE. 2008. 71420I. (Proceedings of SPIE, Vol. 7142). https://doi.org/10.1117/12.815269