Fibres for controlled drug delivery by electrospinning

Niina Ahola, Minna Kellomäki, Pirjo Heikkilä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

Electrospinning is a method that can be used in the production of polymeric nanofibres. Polymer solution is drawn into nanosized fibres utilizing electric field. The small fibre diameter, small pore size, and high surface area of the nanofibre web are properties that are advantageous for many applications including many medical applications. In addition to neat polymers, solutions containing additives and fillers can also be used to functionalize fibres in specific ways. Drug delivery materials can be prepared by electrospinning by including pharmaceuticals into fibres composing of biodegradable polymer matrix. In this study, poly(L-lactide-co-?-caprolactone) with comonomer ratio of 70/30 (PLCL) fibres containing 2-phospho-L-ascorbic acid trisodium salt (AA-salt) as a model compound for drug delivery were electrospun from acetic acid solution. Appearance of electrospun fibres was observed and the release of the model compound from fibrous samples was studied in vitro. Suitability of such electrospun fibre web for controlled drug delivery are evaluated and discussed.
Original languageEnglish
Title of host publicationProceedings
Subtitle of host publicationInternational Conference on Fibrous Products in Medical and Health Care, FiberMed11
EditorsPäivi Talvenmaa
Place of PublicationTampere
PublisherTampere University of Technology
ISBN (Print)978-952-15-2607-7
Publication statusPublished - 2011
MoE publication typeA4 Article in a conference publication
EventInternational conference on Fibrous Products in Medical and Health Care, FiberMed11 - Tampere, Finland
Duration: 28 Jun 201130 Jun 2011

Conference

ConferenceInternational conference on Fibrous Products in Medical and Health Care, FiberMed11
Abbreviated titleFiberMed11
CountryFinland
CityTampere
Period28/06/1130/06/11

Fingerprint

Controlled drug delivery
Electrospinning
Fibers
Polymer solutions
Nanofibers
Drug delivery
Biodegradable polymers
Medical applications
Polymer matrix
Acetic Acid
Ascorbic Acid
Pore size
Fillers
Salts
Electric fields

Keywords

  • electrospinning
  • drug delivery
  • controlled release
  • poly(L-lactide-co-?-caprolactone)
  • ascorbic acid salt

Cite this

Ahola, N., Kellomäki, M., & Heikkilä, P. (2011). Fibres for controlled drug delivery by electrospinning. In P. Talvenmaa (Ed.), Proceedings: International Conference on Fibrous Products in Medical and Health Care, FiberMed11 Tampere: Tampere University of Technology.
Ahola, Niina ; Kellomäki, Minna ; Heikkilä, Pirjo. / Fibres for controlled drug delivery by electrospinning. Proceedings: International Conference on Fibrous Products in Medical and Health Care, FiberMed11. editor / Päivi Talvenmaa. Tampere : Tampere University of Technology, 2011.
@inproceedings{f3c7c0508ff248509e6c0a0b904cd903,
title = "Fibres for controlled drug delivery by electrospinning",
abstract = "Electrospinning is a method that can be used in the production of polymeric nanofibres. Polymer solution is drawn into nanosized fibres utilizing electric field. The small fibre diameter, small pore size, and high surface area of the nanofibre web are properties that are advantageous for many applications including many medical applications. In addition to neat polymers, solutions containing additives and fillers can also be used to functionalize fibres in specific ways. Drug delivery materials can be prepared by electrospinning by including pharmaceuticals into fibres composing of biodegradable polymer matrix. In this study, poly(L-lactide-co-?-caprolactone) with comonomer ratio of 70/30 (PLCL) fibres containing 2-phospho-L-ascorbic acid trisodium salt (AA-salt) as a model compound for drug delivery were electrospun from acetic acid solution. Appearance of electrospun fibres was observed and the release of the model compound from fibrous samples was studied in vitro. Suitability of such electrospun fibre web for controlled drug delivery are evaluated and discussed.",
keywords = "electrospinning, drug delivery, controlled release, poly(L-lactide-co-?-caprolactone), ascorbic acid salt",
author = "Niina Ahola and Minna Kellom{\"a}ki and Pirjo Heikkil{\"a}",
note = "Proc. on CD-ROM",
year = "2011",
language = "English",
isbn = "978-952-15-2607-7",
editor = "P{\"a}ivi Talvenmaa",
booktitle = "Proceedings",
publisher = "Tampere University of Technology",
address = "Finland",

}

Ahola, N, Kellomäki, M & Heikkilä, P 2011, Fibres for controlled drug delivery by electrospinning. in P Talvenmaa (ed.), Proceedings: International Conference on Fibrous Products in Medical and Health Care, FiberMed11. Tampere University of Technology, Tampere, International conference on Fibrous Products in Medical and Health Care, FiberMed11, Tampere, Finland, 28/06/11.

Fibres for controlled drug delivery by electrospinning. / Ahola, Niina; Kellomäki, Minna; Heikkilä, Pirjo.

Proceedings: International Conference on Fibrous Products in Medical and Health Care, FiberMed11. ed. / Päivi Talvenmaa. Tampere : Tampere University of Technology, 2011.

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

TY - GEN

T1 - Fibres for controlled drug delivery by electrospinning

AU - Ahola, Niina

AU - Kellomäki, Minna

AU - Heikkilä, Pirjo

N1 - Proc. on CD-ROM

PY - 2011

Y1 - 2011

N2 - Electrospinning is a method that can be used in the production of polymeric nanofibres. Polymer solution is drawn into nanosized fibres utilizing electric field. The small fibre diameter, small pore size, and high surface area of the nanofibre web are properties that are advantageous for many applications including many medical applications. In addition to neat polymers, solutions containing additives and fillers can also be used to functionalize fibres in specific ways. Drug delivery materials can be prepared by electrospinning by including pharmaceuticals into fibres composing of biodegradable polymer matrix. In this study, poly(L-lactide-co-?-caprolactone) with comonomer ratio of 70/30 (PLCL) fibres containing 2-phospho-L-ascorbic acid trisodium salt (AA-salt) as a model compound for drug delivery were electrospun from acetic acid solution. Appearance of electrospun fibres was observed and the release of the model compound from fibrous samples was studied in vitro. Suitability of such electrospun fibre web for controlled drug delivery are evaluated and discussed.

AB - Electrospinning is a method that can be used in the production of polymeric nanofibres. Polymer solution is drawn into nanosized fibres utilizing electric field. The small fibre diameter, small pore size, and high surface area of the nanofibre web are properties that are advantageous for many applications including many medical applications. In addition to neat polymers, solutions containing additives and fillers can also be used to functionalize fibres in specific ways. Drug delivery materials can be prepared by electrospinning by including pharmaceuticals into fibres composing of biodegradable polymer matrix. In this study, poly(L-lactide-co-?-caprolactone) with comonomer ratio of 70/30 (PLCL) fibres containing 2-phospho-L-ascorbic acid trisodium salt (AA-salt) as a model compound for drug delivery were electrospun from acetic acid solution. Appearance of electrospun fibres was observed and the release of the model compound from fibrous samples was studied in vitro. Suitability of such electrospun fibre web for controlled drug delivery are evaluated and discussed.

KW - electrospinning

KW - drug delivery

KW - controlled release

KW - poly(L-lactide-co-?-caprolactone)

KW - ascorbic acid salt

M3 - Conference article in proceedings

SN - 978-952-15-2607-7

BT - Proceedings

A2 - Talvenmaa, Päivi

PB - Tampere University of Technology

CY - Tampere

ER -

Ahola N, Kellomäki M, Heikkilä P. Fibres for controlled drug delivery by electrospinning. In Talvenmaa P, editor, Proceedings: International Conference on Fibrous Products in Medical and Health Care, FiberMed11. Tampere: Tampere University of Technology. 2011