Electrospinning is a method that can be used in the production of polymeric nanofibres. Polymer solution is drawn into nanosized fibres utilizing electric field. The small fibre diameter, small pore size, and high surface area of the nanofibre web are properties that are advantageous for many applications including many medical applications. In addition to neat polymers, solutions containing additives and fillers can also be used to functionalize fibres in specific ways. Drug delivery materials can be prepared by electrospinning by including pharmaceuticals into fibres composing of biodegradable polymer matrix. In this study, poly(L-lactide-co-?-caprolactone) with comonomer ratio of 70/30 (PLCL) fibres containing 2-phospho-L-ascorbic acid trisodium salt (AA-salt) as a model compound for drug delivery were electrospun from acetic acid solution. Appearance of electrospun fibres was observed and the release of the model compound from fibrous samples was studied in vitro. Suitability of such electrospun fibre web for controlled drug delivery are evaluated and discussed.
|Title of host publication||Proceedings|
|Subtitle of host publication||International Conference on Fibrous Products in Medical and Health Care, FiberMed11|
|Place of Publication||Tampere|
|Publisher||Tampere University of Technology|
|Publication status||Published - 2011|
|MoE publication type||A4 Article in a conference publication|
|Event||International conference on Fibrous Products in Medical and Health Care, FiberMed11 - Tampere, Finland|
Duration: 28 Jun 2011 → 30 Jun 2011
|Conference||International conference on Fibrous Products in Medical and Health Care, FiberMed11|
|Period||28/06/11 → 30/06/11|
- drug delivery
- controlled release
- ascorbic acid salt
Ahola, N., Kellomäki, M., & Heikkilä, P. (2011). Fibres for controlled drug delivery by electrospinning. In P. Talvenmaa (Ed.), Proceedings: International Conference on Fibrous Products in Medical and Health Care, FiberMed11 Tampere University of Technology.