Fibres for controlled drug delivery by electrospinning

Niina Ahola, Minna Kellomäki, Pirjo Heikkilä

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingsScientificpeer-review

Abstract

Electrospinning is a method that can be used in the production of polymeric nanofibres. Polymer solution is drawn into nanosized fibres utilizing electric field. The small fibre diameter, small pore size, and high surface area of the nanofibre web are properties that are advantageous for many applications including many medical applications. In addition to neat polymers, solutions containing additives and fillers can also be used to functionalize fibres in specific ways. Drug delivery materials can be prepared by electrospinning by including pharmaceuticals into fibres composing of biodegradable polymer matrix. In this study, poly(L-lactide-co-?-caprolactone) with comonomer ratio of 70/30 (PLCL) fibres containing 2-phospho-L-ascorbic acid trisodium salt (AA-salt) as a model compound for drug delivery were electrospun from acetic acid solution. Appearance of electrospun fibres was observed and the release of the model compound from fibrous samples was studied in vitro. Suitability of such electrospun fibre web for controlled drug delivery are evaluated and discussed.
Original languageEnglish
Title of host publicationProceedings
Subtitle of host publicationInternational Conference on Fibrous Products in Medical and Health Care, FiberMed11
EditorsPäivi Talvenmaa
Place of PublicationTampere
PublisherTampere University of Technology
ISBN (Print)978-952-15-2607-7
Publication statusPublished - 2011
MoE publication typeA4 Article in a conference publication
EventInternational conference on Fibrous Products in Medical and Health Care, FiberMed11 - Tampere, Finland
Duration: 28 Jun 201130 Jun 2011

Conference

ConferenceInternational conference on Fibrous Products in Medical and Health Care, FiberMed11
Abbreviated titleFiberMed11
CountryFinland
CityTampere
Period28/06/1130/06/11

Keywords

  • electrospinning
  • drug delivery
  • controlled release
  • poly(L-lactide-co-?-caprolactone)
  • ascorbic acid salt

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  • Cite this

    Ahola, N., Kellomäki, M., & Heikkilä, P. (2011). Fibres for controlled drug delivery by electrospinning. In P. Talvenmaa (Ed.), Proceedings: International Conference on Fibrous Products in Medical and Health Care, FiberMed11 Tampere University of Technology.